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Biomedical subjects

N I Tarasov

Publications and source records attributed to N I Tarasov.

At least 19 recordsLinked to original sources
PubMed2006

[MRT assessment of metabolic and thrombolytic therapy effects on postinfarction left ventricular remodeling].

AIM: To examine effects of trimetasidine on morphofunctional indices of the left ventricle (LV) in myocardial infarction (MI) patients on combined treatment. MATERIALS AND METHODS: Seventy five patients with primary macrofocal MI were randomized into 2 groups. Patients of group 1 (n = 38) received a combination of bisoprolol (beta-blocker) with enalapril (ACE inhibitor) in individual doses under control of blood pressure and blood creatinine level. Group 2 (n = 37) patients received the same combination of drugs and, in addition, trimetasidine in a dose 70 mg/day from postmyocardial day 7-10 for 6 months. Two subgroups from the groups were given systemic thrombolytic therapy (STLT) with streptokinase. MRT and cine-MRT of the heart were made for measurement of LV morphofunctional parameters. RESULTS: Low-field MRT of the heart in MI patients treated with adjuvant STLT (1500000 U within 6 hours after MI onset) and trimetasidine (preductal MB) in a dose 70 mg/day from the disease day 7-10 registered a significant inhibition of pathological LV postinfarction remodeling: a decrease of body surface indexed LV end diastolic volume by 10.3%, systolic volume--by 15.4%, LV myocardial tension--by 14.0%, sphericity index--by 7.1%; an increase in the index of relative wall thickness by 5.3%, cardiac index--by 9.2% compared to the group treated without trimetasidine. CONCLUSION: 6-month therapy with trimetasidine of MI patients leads to a significant regress of morphofunctional changes accompanying LV remodeling. Pathological LV postinfarction remodeling inhibits significantly in MI patients combined treatment of whom included STLT (streptokinase in a dose 1500,000 U within 6 hours after acute MI onset and trimetasidine in a dose 70 mg/day on postmyocardial infarction day 7-10).

Adrenergic beta-Antagonists↗
PubMed2004

Experimental and clinical study of the demineralized bone allografts manufactured in the tissue bank of CITO.

The technology for producing demineralized bone allografts (DBA) with definable degree of demineralization and sterilization by high energy electron bean was developed in the tissue bank of Central Institute of Traumatology and Orthopaedics (CITO). The authors consider the technology to be one of the ways of producing demineralized bones. The results of the experiments show that time of demineralization process as well as the absorption dose of radioactive high energy electron beam change substantially mechanical toughness and osteoinductive properties of DBA. Mechanical properties of DBA were tested by the universal testing machine 'Zwick 1464'. Quantitative assessment of DBA osteoinductive properties resulted from the investigation of DBA samples in the culture of stromal precursor bone marrow cells and in the culture of human skin fibroblasts. Cloning efficiency of fibroblasts was considered as indecies of proliferative potential of stromal bone marrow cells, i.e. osteogenic precursor cells. The growth of the cell mass after definite time as well as the index of 3H-timidin marked cells within biological inductor were considered as indecies of proliferative potential of skin fibroblasts. The obtained results showed, that inductive properties of allografts improve when the degree of their demineralization increases whereas the dose of high energy electron radiation decreases. Mechanical toughness of DBA deteriorates when both degree of their demineralization and radiation doses increase. This emphasizes the importance of optimizing technological stages in DBA producing. Since 1998 DBA have been used in Russian clinics for bone plasty in traumatology and orthopaedics, maxilla-facial surgery, ophthalmology, and neurosurgery. The resulting analysis is based on case histories of 257 patients operated from March 1998 to July 2002. The majority of patients were children and teenagers of 3-18 years old with prime tumors, tumor-like and systemic inherited diseases of skeleton, post-traumatic complications. Observation periods were from 1.5 to 5 years and 10 months. Good and satisfactory results were obtained in 93.4% cases.

Adolescent↗
PubMed2004

[Dynamics of lipid peroxidation and antioxidant defense in response to dalteparin therapy in acute coronary syndrome].

The aim of the study was examination of lipid peroxidation (LPO) and antioxidant system (AOS) in patients with acute coronary syndrome (ACS); evaluation of the effect of dalteparin therapy on LPO and ACS. Fifty one patients (mean age 57.5 +/- 1.5 years) were randomized into two groups: group 1 (n = 31) received low-molecular heparin dalteparin, group 2 (n = 17) was given non-fractionated heparin. The course of the anticoagulant therapy lasted 8 days. LPO and antioxidant defense in plasm and blood red cells were investigated on day 1 and 9. ACS patients appeared to have elevated LPO products production both in plasm and blood red cells, low plasm antioxidant activity (AOA). Dalteparin therapy lowered content of malonic dialdehyde (MD) in red cells and plasm, AOA enhanced. Heparin activity was lower: MDA in plasm decreased in a lesser degree while MDA in red cells continued to rise in lowering AOA in plasm and inhibition of catalase.

Acute Disease↗
PubMed2002

[Impact of transrectal microwave hyperthermia on hemodynamics and prostatic cell membranes in chronic prostatitis].

An Aden-Ch apparatus programming complex made in our country was used for transrectal microwave hyperthermia in 75 patients with chronic prostatitis. In addition to its good clinical results achieved in most patients, the complex restored hemodynamics and stabilized the status of prostatic cell membranes. The complex described in the paper may be recommended for the treatment of chronic prostatitis.

Adult↗
PubMed2002

[State of lipid peroxidation, blood antioxidant defense in patients with myocardial infarction aggravated by circulatory insufficiency].

AIM: To study free radical processes in patients with myocardial infarction (MI) aggravated by heart failure. MATERIAL AND METHODS: Forty seven patients taken to the clinic within the first 5 hours of MI were examined. The patients were divided into 2 groups: 1) those with left ventricular failure-complicated IM (n = 25); 2) those with uncomplicated MI (n = 22). A control group included 17 apparently healthy males. The activity of lipid peroxidation (LPO) and blood antioxidative defense was determined in the patients' red blood cells prewashed off the plasma with saline solution at a temperature of 4 degrees C. RESULTS: The tension of free radical lipid oxidation mechanisms in patients with MI aggravated by circulatory insufficiency is followed by an increased antiradical activity. In patients with uncomplicated higher LPO activity is attended the less marked activation of antioxidative enzymes. The examinees were found to show a correlation of the global systolic function of the left ventricle with the concentration of LPO products and with the activity of antioxidative enzymes. CONCLUSION: More significant LP activation coupled with left ventricular systolic dysfunction was noted in patients with MI aggravated by acute heart failure.

Antioxidants↗
PubMed2001

[The role of intracardiac hemodynamic parameters in prognosis of cardiac failure in myocardial infarction patients].

Two-dimensional echocardiography was used to study intracardiac hemodynamics (end systolic, end diastolic volumes and left atrial ejection fraction; end systolic, end diastolic volumes and left ventricular fraction; mean pressure in the pulmonary artery; myocardial mass of the left ventricle) in 49 patients 2, 10 and 30 days after onset of macrofocal myocardial infarction (MI). It was found that patients with and without cardiac failure after one year of the diseases significantly differed by volume and function of the left ventricle and atrium registered since MI day 2. Probability of cardiac failure in the postinfarction period may be estimated since the disease day 2 by an increase in the end-systolic and end-diastolic volumes and left ventricular ejection fraction. A restrictive type of left ventricular diastolic dysfunction is one of the early prognostic criteria of cardiac failure in postinfarction period.

Adult↗
PubMed1999

[Clinical and prognostic significance of the degree of delayed ventricular function and vegetative regulation of cardiac rhythm in myocardial infarction patients].

Ventricular tachyarrhythmias (VT) are responsible for many sudden deaths in postmyocardial infarction (PMI) patients. The aim of the study was to investigate clinical and prognostic significance for such patients of delayed ventricular activity and vegetative regulation of cardiac rhythm. Signal-averaged ECG, mathematical analysis of cardiac rhythm with measurement of variation range, mode, index of regulatory systems tension, 24-h ECG monitoring were made in 90 patients with acute large-focal myocardial infarction (MI) on the disease day 1, 15, 40 and 365. Signal-averaged ECG registered on MI day 15 was found most informative for identifying the risk to develop VT. Combined application of diagnostic techniques brings more information than each of them alone.

Adult↗
PubMed1998

[Substantiation of patients' length stay in hospital after acute myocardial infarct].

AIM: To study and validate the duration of optimal hospital stay for postmyocardial infarction patients and to specify indications for their discharge. MATERIALS AND METHODS: The trial enrolled 187 patients with large- and small-focal acute myocardial infarction. The patients were divided into two groups by different speed of activization and hospital stay. RESULTS: There were no significant differences between the groups with different duration of hospital stay by working ability and invalidism. Temporary disability in patients who have undergone standard rehabilitation was longer than in patients on the shorter-program rehabilitation. Performance of exercise tests on day 14 distinguished patients with a favourable long-term prognosis who were candidates for shorter rehabilitation program. CONCLUSION: The program of quicker rehabilitation (a two-times decrease in the hospital stay) can be applied to patients with uncomplicated myocardial infarction without damage to their health.

Adult↗
PubMed1998

[Clinical and occupational prognosis in myocardial infarction patients which were on different activation regimens and stayed in hospital for different time].

Two groups of patients with Q and non-Q myocardial infarction were compared: 105 patients who underwent early activization and were discharged early and 82 patients treated according to the routine 3-5-week program. The activization implied physical rehabilitation which took 2 times less time than the standard one. It is shown that disability of patients rehabilitated for shorter period of time was significantly shorter. The criteria allowing shorter hospitalization for myocardial infarction patients are proposed.

Adult↗
PubMed1997

[Late ventricular potentials and autonomic cardiac rhythm regulation in patients with acute myocardial infarction].

Relationship between late ventricular potentials (LVP) and vegetative regulation of cardiac rhythm was investigated in 52 patients with acute myocardial infarction. Using signal-averaged ECG and mathematical analysis of cardiac rhythm registered on infarction days 1, 15 and 40 it was found that by disease day 40 a direct correlation became more and more evident between inhibited ventricular activity and the intensity of sympathetic impacts on cardiac rhythm. Thus, the onset of ventricular arrhythmia in patients with myocardial infarction is resultant not only from the presence of arrhythmia substrate, but also from "the autonomic background".

Adult↗
PubMedDate not supplied

[Changes in serum levels of lipid peroxidation products and ceruloplasmin in patients with benign prostatic hyperplasia in uncomplicated and complicated periods after transurethral electro-resection].

Lipid peroxidation products and ceruloplasmin in the serum were measured in 78 patients with benign prostatic hyperplasia (BPH) in uncomplicated or complicated period after transurethral resection of the prostate (TUR) and before it. In uncomplicated period, a short rise in lipid peroxidation activity and lowering of ceruloplasmin concentrations were followed by normalisation by day 6. In the complicated postoperative period by day 6 these indices were higher. The authors propose that these indices are used in assessment of antioxidants efficacy after TUR for BPH.

Aged↗
PubMedDate not supplied

[Doppler ultrasonography of penile vessels in combination with various methods of erectile stimulation in diagnosis of erectile dysfunction].

Ultrasonic dopplerographic investigation (Ultramark-9, USA) was made in 227 males. 50 males with normal erection served controls. Stimulation of erection with an individual LOD-device is a low-invasive, convenient to standardize technique in ultrasonic dopplerographic examination of penile vessels for diagnosis of erectile dysfunction. Erection stimulation by different methods in the same patient during penile vessel dopplerography raises diagnostic value of this method.

Adult↗
PubMedDate not supplied

[Surgical treatment of erectile dysfunction in Peyronie's disease].

Methods of surgical treatment of fibroplastic induration of the penis are briefly reviewed. Supplements to classification of Peyronie's disease are proposed regarding the degree of erectile dysfunction and the angle of the penis deformity in erection. The authors analyse the results of operations performed from 1987 to 2000: Nesbit's operation (n = 13), intracavernous penis prosthesis (n = 48), dissection of the fibrous plaque, the defect repair with preserved dura mater followed by intracavernous prosthesis (n = 10). Indications for various surgical procedures in Peyronie's disease are described.

Adult↗