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Biomedical subjects

N Ia Kovalenko

Publications and source records attributed to N Ia Kovalenko.

26 records · Page 2Linked to original sources
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[Changes in individual resistance of cardiovascular and respiratory systems of rats to posthemorrhagic hypoxia after pharmacological impact on brain function].

In experiments on rats it was shown that injection to rats before hemorrhage of analeptic corasol or prior injections during three days of the inhibitory mediator sodium oxybutyrate decrease individual resistance of the respiratory and circulatory systems (arterial blood pressure, cardiac output, organ portal blood flow) to posthemorrhagic hypoxia. Injection to animals before the hemorrhage of GABA-A antagonist picrotoxin significantly raises individual resistance to massive bleeding. Individual resistance to acute hemorrhage correlates with individual sensitivity of cardiovascular and respiratory systems to corasol.

Animals↗
PubMedDate not supplied

[Cardiovascular system in rats with varying resistance to acute hemorrhage].

Ultrasonic and laser doppler flowmetry, biomicroscopy were used in the study of systemic hemodynamics, microcirculation, blood flow in the brain, liver, kidneys and inferior limb in rats varying by resistance to acute blood loss. In the course of bleeding both high- and low-resistant rats (HRR, LRR) had the same decline in blood pressure, blood flow rate and tissue perfusion. When blood loss stopped. HRR developed relative compensation of the above parameters followed by irreversible fall. Posthemorrhagic recovery of these hemodynamic parameters in LRR was not observed. All the LRR showed persistent generalized constriction of hepatic, intestinal and renal microcirculation. Pumping performance of the heart continued to death in all HRR and in 65% of LRR. After stop of hemorrhage, 35% of LRR developed minor cardiac ejection syndrome which was followed by death within 30 min.

Acute Disease↗