[An autopsy case of primary non-Hodgkin lymphoma of the extrahepatic bile duct].
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Bile Duct Neoplasms↗
Biomedical subjects
N Inui
Publications and source records attributed to N Inui.
[A case of pulmonary alveolar proteinosis presenting with peripheral infiltrates].
We report a case of pulmonary alveolar proteinosis (PAP). A 39-year-old asymptomatic woman was admitted to our hospital because of abnormal shadows on chest X-ray films. Chest X-ray films revealed peripheral infiltrates in both lungs. Computed tomographic examination showed patchy peripheral ground-glass attenuation, concentrated subpleurally. Bronchoalveolar lavage fluid was clear. Because transbronchial lung biopsy findings were inconclusive, a VATS-biopsy was performed. The specimens demonstrated accumulation of proteinaceous materials within alveolar spaces. The patient was given a diagnosis of PAP. Although the distribution of radiographic shadows varies in patients with PAP, perihilar or centralized shadows usually predominate. In our patient, subpleural areas of the lung were affected almost exclusively.
Adult↗
Practice and serial reaction time of adolescents with autism.
This study examined effects of practice on timing of serial reactions by 7 adolescents diagnosed with autism by using a task requiring they track a series of timed lights. The adolescents showed significantly slower and more variable mean simple reaction time than 10 normal control subjects of the same age. On a task of tracking a serial light stimulation for 4 days, on the other hand, significant effects of practice on timing of serial reactions were observed for mean serial reaction times of them. In addition, from individual variations in reaction times and anticipatory reaction times, four of seven subjects with autism showed significant effects of practice. Analysis suggested that these autistic adolescents may be chunking together the whole series of responses and are unable to coordinate the timing of individual responses with individual stimuli. Our data indicate that at least some adolescents with autism are able to form and utilise a motor program with practice.
Adolescent↗
Interactions: timing and force control of finger-tapping sequences.
This study examined effects of combinations of intertap interval and muscle force on interactions between two factors in sequences of equally paced finger taps. 12 male college students tapped a force plate connected to strain gauges. Subjects firstly tapped the plate at a preferred pace and force for 12 sec. Next, subjects tapped the plate by half or double the preferred pace. A series of finger-tapping tasks the consisted of nine combinations of pace and force. Analysis showed that, although variations in intertap interval were considerably accurately controlled across conditions, those in peak forces were not. Movement timing of tapping sequences hence appeared to be independent of force control. For six of 12 subjects, on the other hand, positive correlations between spontaneous variations in intertap interval and in forces were noted. Then, although motor timing was independent of force control in controls of low pace and weak forces, there were strong interactions between the two factors under high pace conditions.
Adult↗
[Pulmonary cryptococcosis exhibiting diffuse multiple nodular shadows].
We report a case of pulmonary cryptococcosis showing diffuse multiple nodular shadows in all lung fields. A 39-year-old woman with no immunological abnormalities was admitted with complaints of cough and sputum. She had experienced measles 4 weeks prior to admission. Chest x-ray films revealed diffuse nodular opacities throughout the lung fields, a finding suggestive of metastatic lung cancer. Detailed examinations, including transbronchial lung biopsy, were not conclusive. A diagnosis of pulmonary cryptococcosis was made on the basis of findings from video-assisted thoracoscopic biopsy. Primary pulmonary cryptococcosis usually appears as a solitary nodule or limited infiltration. Immunologically compromised hosts commonly demonstrate various abnormal shadows, such as the multiple nodular shadows observed in our patient. It has been reported that measles infection can cause temporary immune suppression. Secondary immunodeficiency resulting from the preceding infection with measles could explain the unusual chest x-ray findings in this case.
Adult↗
Simple reaction times and timing of serial reactions of middle-aged and old men.
The timing control of serial reactions in 20 middle-aged (38-43 years) and 20 older men (57-63 years) was examined by using a task of tracking serial-light stimuli with and without the previous learning (Exps. III and II, respectively). In Exp. I, a control group of 20 college students (19-22 years) had significantly faster and less variable mean simple reaction times than the two other groups. For the serial reaction times (Exps. II and III), the control group had significantly faster mean reaction times than the other groups who did not differ. In Exp. III, there was no difference between the serial reaction times and the simple reaction times in the contrasting groups. In Exp. II, however, although the serial reaction times were significantly slower than the simple reaction times in the older group, the serial reaction times did not differ from the simple reaction times in the middle-aged group. The difference between these groups appeared to be due to the task in Exp. II being more difficult than that in Exp. III, suggesting the more complex the movement to be made, the slower the responses of older people. Advancing age seems to have a greater effect on central processing components than on the perceptual and motor output components of serial reactions.
Age Factors↗
Analysis of CA repeats in first intron of class I ADH gene in Long-Evans Cinnamon rats developing fatal intoxication after ethanol intake.
The Long-Evans Cinnamon (LEC) rat is a mutant strain established from Long-Evans rats that displays spontaneous hepatitis and liver cancer. We previously demonstrated that LEC rats died of acute ethanol intoxication after being fed a liquid diet containing 5% ethanol. Furthermore, we found that both alcohol dehydrogenase (ADH) and aldehyde dehydrogenase activities were remarkably suppressed in the liver of LEC rat, compared with Wistar rats. In the present study, we further investigated ethanol metabolism in the non-ADH pathway and what caused the decrease of liver ADH activity in LEC rats. Blood ethanol concentration 5 hr after intraperitoneal administration of ethanol in LEC rats was higher than in the Wistar rats, indicating that ethanol oxidation was impaired in LEC rats. The expression of liver cytochrome P-450IIE1 in the LEC rat was as much as that in Wistar rats. Regarding decreased ADH activity in the liver of LEC rats, we examined an alternating purine-pyrimidine (CA) repeat-length polymorphism in the first intron of a class I ADH gene that would play a role in altering ADH activity. A polymerase chain reaction method was used to amplify the CA repeat in the first intron of this class I ADH gene, a nine CA repeat insertion and a point mutation were detected in LEC rats. These results suggest that this alternating sequence would modify transcription of the class I ADH gene in LEC rats. Thus, LEC rats have abnormal ethanol metabolism in the ADH pathway.
Alcohol Dehydrogenase↗
Detection of activity in the conditioned medium of ethanol-treated HepG2 cells which stimulates collagen synthesis in IMR-90 cells.
Hepatic fibrosis often occurs in alcoholic liver diseases without accompanying tissue necrosis or inflammation. However, the precise mechanism of this fibrosis has not been fully clarified. In the present study, using the hepatoblastoma cell line HepG2 as a model for hepatocytes, we identified a factor that stimulates collagen synthesis of fibroblasts in a conditioned medium of HepG2 cells after treatment with ethanol. Type 1 procollagen peptide (PIC) in a culture of human fibroblast IMR-90 markedly increased after incubation with the conditioned medium of ethanol-treated HepG2 cells. The stimulating activity on the production of PIC by IMR-90 remained after the dialysis and evaporation of the conditioned medium of HepG2 cells, indicating this factor was not as volatile from low molecular substances such as acetaldehyde, acetate, or lactate. The activity of this factor diminished with heat or trypsin treatment. A gel chromatographic analysis disclosed that the molecular weight of this factor was approximately 8000 Da. These results suggest that a polypeptide factor secreted from HepG2 cells by treatment with ethanol stimulates collagen synthesis of fibroblasts.
Carcinoma, Hepatocellular↗
Transfer to changed serial position in a task of tracking a sequence of light stimuli.
This study examined transfer when different serial positions are changed in a task of tracking a sequence of light stimuli. Thirty subjects were divided into three groups, and all tracked a serial pattern of six movements for 20 acquisition trials. Then, on 20 more transfer trials, the last two movements were reversed for Group I, the second two movements reversed for Group II, and the first two movements reversed for the Group III. Performance during the transfer trials improved over performance during the acquisition trials for Groups I and II but not Group III. Thus, there appeared to be positive transfer when the last and middle parts of the serial pattern were changed. However, there was no positive transfer when the first part of the serial pattern was changed. This indicated a contextual interference effect dependent upon serial position in the performance of a serial tracking task.
Adult↗
Simple reaction times and timing of serial reactions of adolescents with mental retardation, autism, and Down syndrome.
The purpose of this study was to examine the serial information processing in adolescents with mental retardation, autism, and Down syndrome by using a serially patterned tracking task. Analyses indicated that 7 adolescents with mental retardation, 8 with autism, and 3 with Down syndrome had significantly slower and more variable simple reaction times than did 10 college students. Also, the autistic adolescents had significantly faster mean simple reaction time than those with Down syndrome. On a task of tracking serial light stimulation, mentally retarded adolescents had significantly faster reaction time than college students. The autistic subjects excessively had faster anticipatory reaction time than did the subjects in the other three groups. On the other hand, adolescents with Down syndrome had markedly slower and more variable reaction time than did adolescents with non-Down-syndrome mental retardation. As for motor organization of keystrokes on the tracking task, mentally retarded adolescents responded with six movements, in which these individuals pressed a series of keys 1, 2, 3, 4, 5, and 6, as a chunk, as exhibited by college students. Adolescents with autism and Down syndrome, however, did not produce this movement-output chunking.
Adolescent↗
[A case of eosinophilic pneumonia associated with Mycobacterium avium infection].
A 54 year-old woman was admitted with cough and high fever. Computed tomographic scan of the chest showed bilateral patchy infiltrates, predominantly in the upper lobes. Eosinophils in the bronchoalveolar lavage fluid (BALF) accounted for 19% of BALF cells. Furthermore, Mycobacterium avium was isolated from a bronchial washing from the upper area of the right lung (S3) and a sample of sputum which had been submitted for microbial examination about 1 month before admission by another clinic. Based on these finding's the diagnosis of eosinophilic pneumonia associated with Mycobacterium avium infection was established. The infiltrates of the lung rapidly decreased after administration of antituberculous agents. The simultaneous presentation of eosinophilic pneumonia and Mycobacterium avium infection has not been previously reported. Because of the efficacy of antituberculous agents in this case, we concluded that Mycobacterium avium was a cause of eosinophilic pneumonia.
Female↗
IgM-complexed aspartate aminotransferase.
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Aspartate Aminotransferases↗
Universality class for extinction-survival phase transition in one dimension.
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Journal Article↗
Genetic variations in baseline and ultraviolet light-induced sister chromatid exchanges in peritoneal lymphocytes among different mouse strains.
The variation in the induction of sister chromatid exchanges (SCEs) in the peritoneal lymphocytes of different mouse strains was investigated. For the baseline SCEs, BALB/c and outbred ICR showed the lowest frequency and DBA/2 and C57BL/6 the highest. BDF1 (C57BL/6 x DBA/2) was ranked among the highest, while CDF1 (BALB/c x DBA/2) was intermediate between the parental strains. Regarding UV-induced SCEs, BALB/c was less susceptible as compared to DBA/2 and C57BL/6. Both BDF1 and CDF1 showed values significantly higher than BALB/c, but not significantly different from DBA/2 or C57BL/6. ICR was ranked in the susceptible group. For the baseline SCEs of bone marrow cells, the overall ranking among strains was essentially the same as that for the baseline, but different from that for the UV-induced, SCEs in peritoneal lymphocytes. The present results can be explained by assuming that the major genetic factor contributing to the strain-dependent difference in the baseline SCEs is due to a codominant trait of a single allele, but that the UV-induced SCEs are complicated by other genetic factor(s).
Animals↗
Mouse strain differences in induction of micronuclei by base analogues and nucleosides.
The frequency of induced micronucleated polychromatic erythrocytes (MNPCEs) was compared in BALB/c, C57BL/6, and DBA/2 mice after intraperitoneal (i.p.) injection of 5-bromodeoxyuridine (BUdR), 5-fluorodeoxyuridine (FUdR), cytosine arabinoside (Ara-C), 6-mercaptopurine (6-MP), 5-bromouracil (5-BU), thymidine (TdR), uridine (UdR), adenosine (AdR) and guanosine (GdR). The experimental procedure was a single i.p. injection followed by harvest at 30 h. The frequency of MNPCEs was significantly increased in all strains by treatment with BUdR, FUdR, Ara-C and 6-MP compared to vehicle control. TdR and UdR induced MNPCEs slightly in BALB/c mice but showed no effect on C57BL/6 and DBA/2 mice. 5-BU, AdR, and GdR did not increase the frequency of MNPCEs in any mouse strain used. These results suggest that BALB/c mice are more susceptible to induction of MNPCEs by clastogenic base analogues and nucleosides than are C57BL/6 or DBA/2 mice.
Adenine↗
Abnormal ethanol metabolism in Long-Evans Cinnamon rats, a mutant strain developing spontaneous hepatoma.
The Long-Evans Cinnamon (LEC) rat is a mutant strain established from Long-Evans rats. LEC rats display hereditary hepatitis and spontaneous hepatocellular carcinoma (HCC). We first tried to examine effects of ethanol consumption on the development of HCC, and fed a Lieber's liquid diet containing 5% ethanol to LEC rats. However the rats died within 2 weeks because of acute alcohol intoxication. In LEC rats, the concentration of ethanol and acetaldehyde in blood was significantly higher, and liver alcohol dehydrogenase activity was slightly lower and acetaldehyde dehydrogenase activities were remarkably suppressed compared to those of Wistar rats. These results suggest that LEC rats have hereditary deficiencies of ethanol and acetaldehyde metabolizing enzymes.
Acetaldehyde↗
Acrylamide; induction of DNA damage, chromosomal aberrations and cell transformation without gene mutations.
The genotoxic potential of acrylamide monomer (AA), a compound familiar as a raw material of polyacrylamide electrophoresis gel, was extensively investigated in vitro. The results were clear cut: AA did not induce any gene mutations in Salmonella/microsome test systems (TA98, TA100, TA1535, TA1537), Escherichia coli/microsome assay (WP2 uvrA-) up to a dose of 50 mg AA/plate, or in HPRT-locus in Chinese hamster V79H3 cells (AA, 1-7 mM, 24 h treatment). On the other hand, AA showed a strong positive response: (a) in a Bacillus subtilis spore-rec assay (DNA damage) at 10-50 mg/disc, (b) to a chromosomal structural change test (AA, 2-5 mM, 24 h treatment), (c) to a polyploidy test (AA, 1-5 mM, 24 h treatment) in Chinese hamster V79H3 cells, (d) to a cell transformation assay in mouse BALB/c3T3 cells (AA, 1-2 mM, 72 h treatment). Sister chromatid exchange was also weakly but significantly induced by AA (AA, 1-2.5 mM, 24 h treatment) in Chinese hamster V79H3 cells. Carcinogenic potential of AA was reported in mice and rats several years ago. AA thus seems to be a typical clastogenic rodent carcinogen without any gene mutation potential. Furthermore, this experiment showed for the first time positive response of AA to a microbial test system (B. subtilis spore-rec assay).
Acrylamide↗
Inhibitory effects of antipromoters and radical scavengers on the promotion process in two-stage cell transformation.
To find the mechanism of promotion process, we have investigated the antipromoting effects of radical scavengers and specific inhibitors for phospholipid metabolism and for protein kinase C using a two-stage transformation assay system in BALB/3T3 cells. All radical scavengers and inhibitors tested showed the antipromoting effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted transformation. Diacylglycerols, activators of protein kinase C, showed promoting effects in vitro and the promoted-transformation by them was suppressed by radical scavengers employed. By an electron spin resonance (ESR) spin-trapping method, inhibitors, which suppressed promoted-transformation by TPA markedly, had .OH scavenging action. It was found using a ESR spin-trapping method that treatment of TPA on BALB/3T3 cells generates .OH in a dose-dependent manner. These results suggest that generation of oxygen radicals, especially .OH, which occurs in the processes of phospholipid metabolism as well as activation of protein kinase C, is essential to the promotion process.
Animals↗