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N Ionescu

Publications and source records attributed to N Ionescu.

14 recordsLinked to original sources
PubMed1978

Enteric viruses in the Danube river water and sludge.

A study of the viral pollution of the Roumanian course of the Danube river was carried out from 1972 to 1974. The presence of enteric viruses was investigated in 123 water samples, taken by the gauze swab method and in 116 sludge samples from the bottom of the river. The samples were collected from 20 sampling points along the river from Moldova Veche to Brăila, in accordance with the water use and the main pollution sources. Viruses were recovered from 17.5% of the samples. The frequency of virus isolations from water samples was similar to that observed in sludge samples. Therefore, the viral pollution of the Romanian course of the Danube showed a low level in comparison with other rivers, though two concentration techniques into suckling mice and into tissue cultures, were used for each sample.

Enterovirus↗
PubMedDate not supplied

[Comparative results of total detections and detection in a group of patients with high risk for tuberculosis in an urban environment].

In the territory of 5 anti-TBC dispensaries in the area of Bucharest 2 circumscriptions have been selected at random in which radiophotographic detection was to be carried out integrally and 2 other circumscriptions were selected for the investigation of groups at high risk of developing tuberculosis. All the new cases of active pulmonary tuberculosis that have been recorded, through all the methods in these 20 circumscriptions in 1973 were analized retrospectively and the reasons appeared that had determined their existence was mentioned or was ommitted on the occasion of previous investigations. These reasons were correlated with the data concerning the method for detection that had been employed, according to the indications of the tuberculosis dispensaries. In view of the evaluation of the degree of real covering of the population in integral rf investigations, the team of the Institute of Phtysiology investigated representative lots of population from each dispensary and checked the catagraphy of the population in the field, house-by-house. It was noted that 20--21% of the subjects that had been programmed for the integral rf examination (according to catagraphic criteria) were absent when the checking in the field, that should have been programmed, were not included in the catagraphy. On the basis of this study the methodology for radiophotographic detection for groups with risk of developing tuberculosis was established.

Humans↗
PubMedDate not supplied

[261 cases of bronchopulmonary cancer detected by radiophotography].

In Bucharest, district 6, of the 1 151 313 radiophotographies performed, 261 revealed bronchopulmonary cancers (22.6 per 10 000) of which 73% males and 27% females, the 50--70 years age group being the most affected (181 cases, i.e. 70%). The 85% deaths occurred within 2 years after detection. In 68% (177 cases) cancer was peripheral and in 32% centrohillar. The peripheral localization in 68% of the cases opens prospects for an early detection by dynamic follow up of the pulmonary radiophotography at shorter intervals, especially in the age group with a higher cancer risk (50--70 years), indicating in some cases immediate admission to a surgical department.

Adult↗
PubMedDate not supplied

Investigations on the presence of enteroviruses in drinking water.

Out of 220 tap-water samples examined, 3.64% were found to contain enteroviruses. The 11 isolates included 3 attenuated poliovirus, 2 Coxsackie A4 and 6 untyped strains. The necessity of improving the treatment of drinking water, especially by disinfection, is outlined.

Enterovirus↗
PubMedDate not supplied

[Current incidence and clinical significance of non-culturable bacilli or those culturable with difficulty].

An analysis of 246 patients with positive smear present bacilli and negative cultures revealed that in only 9% of the cases no organized previous treatment had been applied, although almost half of these had benefited from short courses with streptomycin associated with penicillin before an exact diagnosis of tuberculosis had been made. Since the remaining 91% had had 1--2 months of chemotherapy, which frequently included rifampicin, the authors stress that microscopically detectable germs are frequently incapable to develop on culture media. These are frequently non-viable bacteria and in such conditions no subsequent modifications of the currently applied therapy scheme should be attempted. The authors show that only 26,2% of the germs from 519 positive cultures have developed after 21 days from the seeding. At 30 days the overall proportion increased to 71,2% while at 45 days 22,7% more positive cultures appeared and an additional 6,1% cultures became positive at 60 days. Tubercle bacilli become increasingly demanding and slower growing. If at 21 days only one colony was evident in 6% of the cases, while an infinite number of colonies were present in 58% of the cultures at 60 days a single colony was found in 42% of the cases, in contrast with only 9% cases with an infinite number of colonies (P less than 0,001). The delay in the growth of bacilli was parallel with the duration of chemotherapy. The results are compared with data from the literature.

Antitubercular Agents↗
PubMedDate not supplied

[Strictly supervised antitubercular chemotherapy in district and plant medical dispensaries in the city of Craiova].

The mode of administration of chemotherapy is evaluated, in conditions of integration, and under strict supervision, in tuberculosis patients in 12 medical dispensaries and in 6 enterprise dispensaries from Craiova over a period of one year. A total of 88,54 +/- 17,99 per cent of the number of programmed doses was administered in the territorial medical dispensary, as compared with 81,9 +/- 21,3 per cent in the tuberculosis dispensary. In enterprise dispensaries 97,69 +/- 16,17 per cent of the doses was given effectively, as compared with 78,17 +/- 29,39 per cent of doses given to the same patients in the tuberculosis dispensary. During the sick-leave 92,14 +/- 9,19 per cent of the doses were given, in the medical territorial dispensary as against 86,98 +/- 17,58 per cent in the tuberculosis dispensary. The difference is not significant. After reinsertion 77,53 +/- 24,84 per cent of the programmed doses were administered in the tuberculosis dispensary, 88,2 +/- 19,84 per cent in the territorial medical dispensary and 97,12 +/- 5,66 per cent in the enterprise dispensary. The differences were not significant. The authors conclude that administration of anti-tuberculosis chemotherapy can be perfectly well carried out in integrated conditions in the urban environment, especially in interprise medical units, after reinsertion. The phtysiologist should make a periodical survey in these units in view of securing a strict administration of the treatment regimens.

Ambulatory Care Facilities↗
PubMedDate not supplied

Electronoptical aspects of the thyroid cold nodule.

The authors studied the ultrastructure of benign and malignant forms of the thyroid cold nodule. In the benign cold nodule the most striking feature was an irregular endoplasmic reticulum with large cisternae and scarce ribosomes, this meaning an impaired protein synthesis. Frequent lysosomes and phagolysosomes occurring in the apical zone of the cell were present. In the malignant form of the cold nodule, nuclear abnormalities, a reduced endoplasmic reticulum and a highly increased number of abnormal mitochondria were found. The increased number of mitochondria in the carcinoma is a compensatory reaction to the frequent abnormalities found in these organelles. No transitional ultrastructural stages could be established between benign and malignant cold nodules. In practice the nature of a cold nodule is established by thyroid surgery and histologic examination.

Adenoma↗