Biomedical subjects

N J Carr

Publications and source records attributed to N J Carr.

43 records · Page 3Linked to original sources

PubMed1993

Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.

This study aimed to determine the diagnostic utility of mast cell densities in distinguishing neurotised ("neural") melanocytic naevi from neurofibromas. Three groups of lesions were studied: neurofibromas, neural naevi, and naevi showing no neural change (control naevi). A Giemsa stain was used to demonstrate mast cells. The median mast cell density in the neurotised naevus group was significantly higher (p < 0.005) than that of both the neurofibroma and control naevus groups, but the distributions of the individual density counts overlapped considerably. The sensitivity and specificity of the mast cell density as a potential discriminator between neurotised naevi and neurofibromas, determined in relation to the optimal discrimination value obtained using Bayes' minimum cost decision rule, were low. It is concluded that mast cell density on its own is of little use as a classification tool but could be of value in the context of a multivariate decision rule.

Adolescent↗

PubMed1992

Chondromyxoid fibroma of the zygoma.

A case of chondromyxoid fibroma (CMF) involving the zygoma is presented. To our knowledge, this case report represents the first description of CMF involving an extragnathic site in the facial skeleton exclusive of the cranium. Total excision and immediate reconstruction were done with alloplastic material fixated with microplates and screws.

Adult↗

PubMed1992

The histological features of splenosis.

This study presents a detailed histological analysis of two cases of splenosis, including one of the largest nodules to be reported. Splenosis may exhibit red and white pulp that appears histologically and immunohistochemically normal by routine methods, and a well-developed capsule and trabeculae may form. The capsule may be thicker than in the normal spleen but is otherwise indistinguishable and may contain fibrous, elastic and smooth muscle elements. These findings are in contrast to previously published works which have described poorly-developed white pulp, capsule and trabeculae in splenosis. The histological pattern may depend on the blood supply to the autotransplanted splenic tissue in the early days after implantation. The close resemblance that splenosis may show to an accessory spleen suggests that histological examination may have a limited role in the distinction between these two conditions.

Adult↗

PubMed1991

What's in a burger?

In an attempt to confirm the presence or absence of central nervous tissue in commercially prepared beefburgers, four burgers were processed and stained using routine histological laboratory techniques. Constituent parts of the burgers could be identified readily. In this small sample no central nervous tissue was found. There is currently considerable general interest in the contents of foodstuffs, particularly now that certain specified bovine offals as well as central nervous tissue have been banned from human consumption. Conventional histological techniques may be of value in analysing the ingredients of beef products.

Animals↗

PubMed1991

Acute aortic valve prolapse in Marfan's syndrome.

A 22 year old man with Marfan's syndrome died suddenly following acute aortic valve prolapse. Although aortic root involvement in Marfan's syndrome is common, we have found no previous description of this particular complication in the literature.

Adult↗

PubMed1988

Testicular cancer presenting as a red swollen lid.

A case is reported in which a testicular cancer presented as a metastatic deposit in the eyelid. The histological appearances of both the metastasis and the subsequently detected primary were diagnostic of malignant teratoma trophoblastic (MTT). After comments on the testicular tumour, metastases occurring in the eye and adnexa are discussed.

Adult↗

PubMedDate not supplied

Intussuscepted colonic lipomas: loss of fat attenuation on CT with pathologic correlation in 10 cases.

BACKGROUND: To determine if infarction and necrosis is the cause of the confusing soft tissue density on CT within intussuscepting lipomas of the colon. METHODS: The clinical records, radiologic examinations, and pathologic specimens of all 13 cases of colonic lipomas collected from 1988 to 1994 studied by CT and surgically resected were retrospectively reviewed. Ten of these cases were associated with intussusception; the CT attenuation of the lead point was graded according to its relative fat/soft tissue density. Pathologic specimens were graded independently by a GI pathologist and graded according to the degree of infarction/fat necrosis. RESULTS: The lipomas ranged from 4 to 7 cm in diameter (mean = 5 cm). Only one case with intussusception, and all three cases without, demonstrated pure fat attenuation on CT and demonstrated pure fat histologically. One case demonstrated soft tissue attenuation and corresponded with the most severely infarcted specimen histologically; two cases with similar but less severe infarction/fat necrosis corresponded with less than 25% fat attenuation. These latter three cases were originally misinterpreted as malignancies rather than lipomas. Six cases maintained greater than 50% fat density and intermediate amounts of infarction/fat necrosis. CONCLUSION: Lipomas may have an atypical appearance when intussuscepted due to varying degrees of infarction/fat necrosis.

Adult↗