Biomedical subjects
N J Dawson
Publications and source records attributed to N J Dawson.
Pre-spinal convergence between thoracic and visceral nerves of the rat.
Dichotomizing sensory axons have been demonstrated in a number of species and are of significance in understanding the possible mechanisms underlying referred pain. The present study reviews work employing fluorescent dyes as tracers to demonstrate afferent dichotomization in the peripheral nervous system. Dichotomization between the intercostal and splanchnic nerves of the rat was demonstrated by means of intraneural transport of Diamidino yellow or Fast blue. Frequency of pre-spinal somato-visceral convergence averaged 2% (range 0.1-21%). Average frequency of convergence was 8.3% (range 2-23.1%) between internal and external intercostal nerves. Control experiments in which axoplasmic transport was inhibited by vinblastine ruled out the possibility of errors from non-axoplasmic transport of the markers. Thoraco-visceral pre-spinal convergence occurs in the rat and is variable in extent.
Need satisfaction in terminal care settings.
Research comparing hospice and conventional programs of care for the terminally ill has identified few measurable differences in the care provided to patients and their families. Nonetheless, hospice recipients frequently express a higher level of satisfaction with their program of care. This study compared the ability of hospice and conventional care settings to meet the basic emotional needs of families during a member's dying and death from cancer. In addition, the relationship of basic needs satisfaction, perceptions about the nurse, and overall satisfaction with the program of care were explored. One hundred bereaved familial care givers completed a mail questionnaire concerning their perceptions of care at the site of a family member's death. The sites were (1) the home, with care provided by a Medicare certified, community-based hospice program: (2) a hospital affiliated with a Medicare certified, community-based hospice program; (3) a hospital with its own hospice program; and (4) a conventional (non-hospice) hospital. Analyses of quantitative data supported two hypotheses about significant differences between hospice and conventional care. The conventional care group demonstrated the lowest levels of basic needs satisfaction, satisfaction with the psycho-social support of the nurse, and overall program satisfaction. As predicted, overall satisfaction with care was consistent across hospice groups. However, home hospice care provided the highest quality of basic needs satisfaction and the highest level of satisfaction with the nurse. Significant Pearson correlations supported the hypothesis that overall satisfaction is negatively related to unmet basic needs (r = -0.69) and positively related to the psycho-social support received from nurses (r = 0.73).(ABSTRACT TRUNCATED AT 250 WORDS)
High molecular weight aggregate content of heated and unheated factor VIII products determined by fast-protein liquid chromatography.
The molecular-weight distribution of proteins in factor VIII concentrates has been analysed by fast-protein liquid chromatography. The proportion of high-molecular-weight (HMW) aggregates in one product increased on freeze-drying and heating, with fibrinogen and fibronectin being the main protein components of the HMW peak. In all other concentrates, the HMW peak was less than or equal to 5% of the total protein content and there were no differences in HMW content according to purity or method of viral inactivation.
Facilitation and suppression of antidromic invasion by orthodromic impulses in the cat [proceedings].
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Contrasting actions of cycloheximide on fever caused by arachidonic acid and by pyrogen [proceedings].
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Thermoregulation during mild exercise.
A comparison was made of the thermoregulatory effects of wearing black or white clothing during exercise under radiant heating. For subjects in black clothing the skin temperature was higher than with white but the rectal temperature and heart rate were lower.
A study of some organs and tissues in mice (Mus musculus) subjected to genetic selection for different body proportions.
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Physiology of heat loss from an extremity: the tail of the rat.
1. Hooded, conscious, male, laboratory rats were subjected to an ambient dry bulb temperature cycle between 12 degrees C and 35 degrees C over a period of approximately 5.5 h. The same procedure was followed using rats in which the temperature surrounding the tail was held constant, and using dead rats. 2. Temperature of the ambient air, and the rectum, flank skin, tail base and tail tip were measured during each ambient temperature cycle. 3. In both living and dead rats, a hysteresis loop was demonstrated for the relationship between all body temperatures measured and ambient temperature. 4. The hysteresis loops for tail temperature differed between living and dead rats in such a way as to indicate that tail temperature began to increase, as a result of an active process, at approximately 30 degrees C, but this response ceased at a lower temperature. 5. The results on rats in which tail ambient temperature was held constant agreed with the preceeding observations. 6. Clear evidence of a counter-current heat exchange system in the vasculature of the rat's tail was not obtained. 7. It is concluded that the tail of the rat resembles an on/off controller in its mode of operation.