Propofol and epilepsy.
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Biomedical subjects
Publications and source records attributed to N J Huggins.
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The pharmacokinetic profile of propofol is an advantage in neurosurgery, where the rapid return of cognitive function is essential for an early postoperative assessment of neurological status. Administration of propofol by 'Diprifusor' target controlled infusion allows induction of anaesthesia in neurosurgical patients without significant reduction of mean arterial pressure or occurrence of apnoeic episodes. This short paper describes our experience of 'Diprifusor' target controlled infusion for neuroanaesthesia in a series of 20 patients undergoing craniotomy for excision of epileptic foci. The results have been compared with ten similar operations where propofol infusion was controlled manually.
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We report a case in which laminectomy was performed in a patient with symptoms attributed to lumbar canal stenosis. The patient developed paraplegia in the early postoperative period. Further investigation revealed a dural arterio-venous malformation. This was treated surgically, producing some neurological recovery. The possible mechanisms for the perioperative deterioration and their implications for anaesthesia are discussed.
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We report a previously undescribed complication of tracheal intubation. The complication arose as a result of tracheal intubation performed as an emergency procedure in a patient with an abnormal anteriorly placed larynx. Subsequent corrective laryngeal surgery was required after a temporary tracheostomy had been performed.
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