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Biomedical subjects

N J Paymaster

Publications and source records attributed to N J Paymaster.

14 recordsLinked to original sources
PubMed1983

Intramuscular meptazinol analgesia after surgery: a study of the dose-response effect and a controlled comparison with pentazocine and pethidine.

In a single-blind study of a new hexahydroazepine analgesic, meptazinol, intramuscular (i.m.) doses of 50-100 mg produced effective, dose-related analgesia in 45 patients recovering from abdominal surgery. The analgesic effect was significant 30 minutes after injection, and was still present after 2 hours. There was a good correlation between pain relief assessed by the patient, by the physician and indirectly by pulmonary function tests. Neither the respiratory nor cardiovascular systems were depressed. There were no abnormal biochemical or haematological findings and the only side effects were nausea and vomiting in a few patients receiving multiple doses of the drug. In a subsequent double-blind investigation in which drugs were given i.m. to 75 abdominal and orthopaedic surgery patients, meptazinol 100 mg was found to be equianalgesic with pentazocine 60 mg and pethidine 100 mg. The duration of action of meptazinol was estimated to be 4 hr. Patients given meptazinol were less sedated than those given pentazocine or pethidine and tended to show a greater improvement in lung function tests. There was no evidence of patient preference for meptazinol or morphine which were administered for further pain relief in a single-blind manner.

Adult↗
PubMed1977

Analgesia after operation. A controlled comparison of meptazinol, pentazocine and pethidine.

In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine 60 mg and pethidine 100 mg when given i.m. Analgesia was maximal 30-60 min after injection and was still present at the end of 2 h. The duration of action of meptazinol was estimated to be 4 h. Meptazinol produced less sedation and a greater sparing of lung function tests than did pethidine and pentazocine. When meptazinol or morphine was administered for further pain relief in a single-blind manner there was no evidence of patient preference for one drug or the other.

Adult↗
PubMed1976

Clinical evaluation of meptazinol. a new analgesic, in postoperative pain.

In a single-blind study of several doses of a new hexahydroazepine analgesic, meptazinol, in 45 patients recovering from major abdominal surgery, there was a dose-related significant analgesic effect from i.m. doses exceeding 50 mg. Pain relief was maximal at the end of 1 h and the duration of effect of the 100-mg dose was approximately 5 h. There was a good correlation between pain relief assessed by the patient, by the physician, and indirectly by pulmonary function tests. Heart rate and arterial pressure were not affected by meptazionol. There were no abnormal biochemical or haematological findings and the only side-effect was vomiting in a few patients receiving multiple doses of the drug.

Adult↗
PubMed1976

Evaluation of anxiolytic and amnesic effects of intramuscular lorazepam as a pre-operative medication.

In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lorazepam produced superior preoperative and post-operative anterograde amnesia, with respect to both incidence and duration. There was no difference in the pre-operative anxiolytic and soporofic effects of the two regimens and post-operatively, analgesic requirements and the incidence of vomitting and restlessness were the same in both groups of patients.

Adult↗
PubMed1976

Clinical assessment of oral meptazinol in postoperative pain.

The pain relieving properties of orally administered meptazinol, a new hexahydroazepine analgesic, were studied in 51 patients recovering from major surgery. In doses of 250, 400 and 500 mg it produced significant analgesia which was maximal at the end of one hour and had a duration of action of approximately four hours. Arterial pressure and heart rate were not affected significantly by meptazinol. Nausea and vomiting were the main side-effects observed in a few patients and there were no abnormal hematological or biochemical findings.

Administration, Oral↗
PubMed1976

Magnesium metabolism: a brief review.

The important role played by the magnesium ion in the body is not generally recognized. The action of numerous enzyme systems critical to cellular metabolism is regulated by it and it contributes importantly to macromolecular structure. Magnesium defiency occurs more often than is generally suspected; magnesium excess, though uncommon, is of special interest to the anaesthetist because it produces a curare-like effect on neuromuscular transmission. It is hoped that this brief review of magnesium metabolism will draw attention to its importance and relevance in everyday practice.

Animals↗
PubMed1975

Postoperative magnesium deficiency.

Prolonged nasogastric suction and the administration of magnesium-free parenteral fluids produced magnesium deficiency in a patient in the postoperative period. The symptoms of magnesium deficiency are usually overshadowed by those of the primary disease and diagnosis usually rests on the demonstration of low blood concentrations of the ion. Magnesium replacement must be kept in mind when treating patients with intravenous fluids for prolonged periods.

Colectomy↗
PubMed1975

The use of indoramin to induce hypotension during general anaesthesia.

The alpha-blocker indoramin had only modest hypotensive action in the normotensive anaesthetised, paralysed patient undergoing major surgical intervention but had a greater effect in the hypertensive patient. The absence of deleterious cardiac effects even with intravenous doses as high as 1 mg/kg. supports previous findings as to the safety of this compound. It is possible that indoramin potentiates the hypotensive action of halothane but there is no evidence to suggest that an adverse interaction might arise when halothane is used to anaesthetise a patient receiving indoramin treatment.

Adrenergic alpha-Antagonists↗