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Biomedical subjects

N J Sarkies

Publications and source records attributed to N J Sarkies.

12 recordsLinked to original sources
PubMed1988

Intracerebral metastases from ocular melanoma.

A blind painful eye may harbour an unsuspected malignant melanoma. We report a case of ocular melanoma that presented with confusion owing to direct extension via the optic nerve into the anterior cranial fossa.

Aged↗
PubMed1987

Optic nerve sheath meningioma: diagnostic features and therapeutic alternatives.

Twenty-two cases of optic nerve sheath meningioma were reviewed. The clinical features included slowly progressive visual loss in every case. Orbital signs of limited ocular movements and mild proptosis were present in only a third of cases; gaze-evoked amaurosis occurred in 3 cases. The disc was abnormal in every case, usually swollen if vision was 6/12 or better, atrophic if the vision worse than 6/12. Optociliary shunt vessels occurred in 5 patients and were of diagnostic significance. The diagnosis was made by a high-resolution CT scan of the orbits showing tubular expansion of the optic nerve sheath. Calcification of the optic nerve was present in 12 cases. Tubular expansion of the optic nerve sheath may occur in raised intracranial pressure, optic nerve glioma, granuloma, lymphoma or metastatic disease. In the absence of calcification these alternative diagnoses must be considered. Surgery, undertaken for the intracranial component of the tumour, did not halt progressive visual loss.

Adolescent↗
PubMed1987

Optic disc drusen and episodic visual loss.

A case is reported in which recurrent episodes of visual loss occurred over a period of 26 years in a patient with bilateral optic disc drusen. Visual field loss was associated with episodes of ischaemic optic neuropathy. The possible mechanism is discussed.

Female↗
PubMed1986

Fluorescein angiography in carotid disease.

Twenty four cases in whom occlusive disease of the carotid artery was proven by digital subtraction angiography or direct carotid arteriography were studied. In five cases venous stasis retinopathy was evident ophthalmoscopically. Fluorescein angiography was abnormal in 19 cases. The abnormalities found were microaneurysms (16 cases); slow arteriovenous transit time (8 cases); macular oedema (8 cases); leakage from the arterioles (3 cases); disc new vessels (4 cases). The differences between this retinopathy and diabetic retinopathy are discussed.

Adult↗
PubMed1985

Ocular disease in immunosuppressed patients.

New therapies and diseases causing immunosuppression have provoked new and devastating ocular diseases. The possible reasons for the vulnerability of the retina to opportunistic infections are discussed. The clinical patterns of disease caused by common opportunistic agents are described, and current treatment available is reviewed.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Silicone tube and gutter in advanced glaucoma.

We performed a new drainage operation in 20 cases of advanced glaucoma. A silicone tube was inserted into the anterior chamber and its outer end buried under an encircling gutter. After a mean follow up of 10 months, in 13 cases (65 per cent) the eye was comfortable, the intraocular pressure less than 25 mm Hg, and the tube was in a satisfactory anatomical position. The authors recommend this procedure rather than destructive operations in eyes with advanced uncontrolled glaucoma.

Adolescent↗
PubMed1985

Convergence spasm.

Convergence spasm, when it is part of the near-response, is accompanied by accommodation and miosis. The differential diagnosis of bilateral sixth nerve palsy, divergence insufficiency, bilateral gaze palsy may be distinguished by clinical examination. In a review of 12 cases, 8 of whom were re-examined after a mean interval of 8.3 years, no organic disease became manifest. We suggest that extensive neurological investigation is not necessary in this group of patients. Treatment with cycloplegia and glasses gave symptomatic relief in 5 cases.

Abducens Nerve↗
PubMedDate not supplied

Assessment by fluorescein angiography of surgical treatment of occlusive carotid artery disease.

Fundus fluorescein angiography was performed in 10 cases of occlusive carotid artery disease at presentation and after surgery or medical treatment. An improvement in the microcirculation of the retina was observed in 4 cases after carotid endarterectomy and in 1 case after carotid endarterectomy and extracranial-intracranial bypass. Improvement was not observed in 2 cases after extracranial-intracranial bypass alone or in 3 cases in which surgical intervention was not undertaken. Our results suggest that carotid endarterectomy is a more effective procedure than extracranial-intracranial bypass in improving retinal perfusion when compromised by ipsilateral carotid obstruction.

Arterial Occlusive Diseases↗