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Biomedical subjects

N J Secher

Publications and source records attributed to N J Secher.

10 recordsLinked to original sources
PubMed1979

Continuous measurement of transcutaneous fetal oxygen tension during labour.

Transcutaneous scalp oxygen tension (tcPO2) was measured during labour in 40 fetuses, using a modified Clark electrode (Radiometer, Copenhagen). In 24 of the fetuses the recordings were of good quality during the second stage of labour. After delivery the acid-base status and oxygenation of the umbilical cord blood was measured. A correlation was found between the tcPO2 and umbilical artery oxygen saturation (r = 0.56, p less than 0.01) and umbilical artery PO2 (r = 0.56, p less than 0.01). Furuthermore, a positive correlation was found between the area beneath the recorded tcPO2 curve during the last 10 minutes and the umbilical artery pH (r = 0.50, p less than 0.05). The data suggest that continuous transcutaneous PO2 measurement may be of value in monitoring high risk patients during labour.

Electrodes↗
PubMed1979

Measurements of cardiac stroke volume in various body positions in pregnancy and during Caesarean section: a comparison between thermodilution and impedance cardiography.

A total of 220 simultaneous pairs of measurements of cardiac stroke volume were made in twelve women before and during Caesarean section in order to compare impedance cardiography with the thermodilution method. A significantly higher coefficient of correlation was found before (r = 0.77) than during anaesthesia (r = 0.55). Further, there was a significant difference in the slope of the regression lines: before anaesthesia the slope was 1.07 and during anaesthesia with thiopentone, nitrous oxide, oxygen and suxamethonium it was 0.45. Significant changes in the intercept on the Y-axis were found before (-13.9 ml) and during anaesthesia (33.4 ml). When the uterus was displaced upwards and to the left from the 15 degrees tilt position the stroke volume and the cardiac output were increased when measured by both methods to nearly the same values as in the left lateral position. It is concluded that the impedance method is reliable for measuring cardiac stroke volume in late pregnancy under physiological conditions in the conscious patient, but that it cannot replace the thermodilution method in pharmacological studies.

Adult↗
PubMed1978

Haemodynamic effects of oxytocin (syntocinon) and methyl ergometrine (methergin) on the systemic and pulmonary circulations of pregnant anaesthetized women.

The haemodynamic effects of oxytocin (Syntocinon) and methyl ergometrin (Methergin) were studied in 9 healthy females in the first trimester of pregnancy. The patients were anaesthetized with sodium thiomebumal, pethidine and pancuronium bromide and ventilated on a Manley respirator. 10 i.u. oxytocin given as an i.v. bolus brought about a fall in femoral arterial pressure of 40%, systemic resistance 59% and pulmonary resistance 44% 30 sec after injection. However, the heart rate increased 31% and stroke volume 17%, so that the cardiac output increased by 54%. The pulmonary arterial pressure and wedge pressure were increased by 33% and 35%, respectively 150 sec after injection. No changes were seen in the haemodynamic parameters during infusion of 80 mU oxytocin for 10 min. 0.2 mg Methergin brought about an increase in the femoral arterial pressure of 11%, pulmonary arterial pressure 27% and wedge pressure 31%, with no changes in the other measured parameters. The use of oxytocic drugs in patients with compromised circulation is discussed.

Adult↗
PubMed1977

Midtrimester and missed abortion treated with intramuscular 15 (s)-15 methyl PGF2alpha.

Abortion was successfully induced in 79 of 80 patients in midtrimester, by the serial administration of 250 microgram of 15 (S)-15 methyl PGF2alpha intramuscularly every second hour until abortion occurred. All 12 patients with missed abortion and 87% of the legal abortion patients aborted within 24 hours. The average period until abortion occurred in the missed abortion group was 8.2 hours (+/- 4.5 SD), and in the legal abortion group 16.4 hours (+/- 7.3 SD). All the patients were given prophylactic treatment for vomiting, using prochlorperazine. The average number of episodes of vomiting was 2.8 per ptient. All but 3 patients were given loperamide or diphenoxylate for "diarrhoea". The average number of episodes of diarrhoea was 2.5 per patient. The frequency of complications was low apart from a case of low uterine rupture.

Abortion, Legal↗
PubMed1977

Changes in the pattern of regional pulmonary blood flow after PGF2alpha infusion in pregnant women.

The central haemodynamics and regional lung function were measured in the sitting position before and after infusion of prostaglandin F2alpha (PGF2alpha) in seven healthy women in the first trimester of pregnancy. The dosage level of PGF2alpha was: 100mug/min for 10 minutes followed by 300mug/min for 5 minutes. The pulmonary arterial pressure, wedge pressure, and cardiac output were measured by means of a flow direct Swan-Ganz catheter introduced through an antecubital vein. The regional perfusion of the lungs was determined, in the sitting position, by external counting over the chest following intravenous injection of Xe133. The thoracic impedance was measured with the Minnesota Impedance Cardiograph Model 304A and the impedance was considered as an expression of the thoracic fluid volume. A significant redistribution of the pulmonary blood flow after PGF2alpha administration was found, ie an increase in the apical blood flow and a reduction in the basal blood flow. Further, the point of maximal blood flow moved in direction of the apex. A significant increase in both arterial [1.92-2.76 kPa (14.4-20.7 mmHg)] and wedge pressures [0.56-0.83 kPa (4.2-6.2 mmHg)] was found at the highest dosage level, whereas no changes were seen in the cardiac output and thoracic impedance. The findings indicate vasoconstriction of the arterial and possibly on the venous side of the pulmonary vascular bed during PGF2alpha infusion.

Blood Pressure↗
PubMed1977

Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study.

Loperamide was compared double-blind with diphenoxylate and a placebo in 59 women with diarrhoea due to prostaglandin administration for mid-trimester abortion. Treatment was started with the intake of two capsules two hours before the first intramuscular injection of 15(S-)15 methyl prostaglandin F2alpha and was then adapted individually, i.e. one capsule after each unformed stool, with a maximum of ten per 24 hours. Both antidiarrhoeals were significantly more effective than the placebo in preventing diarrhoea, and loperamide was found to be more active than diphenoxylate. The course of abortion, BP and vital signs, or prostaglandin side-effects other than diarrhoea were not affected by either antidiarrhoeal, nor could any adverse experience be specifically attributed to them.

Abortion, Induced↗
PubMed1977

Measurement of rapid changes in cardiac stroke volume. An evaluation of the impedance cardiography method.

One hundred and twenty-nine simultaneous measurements were carried out on seven patients, 67 at rest and 62 during the Valsalva manoeuvre, in order to compare impedance cardiography with the thermodilution method, during rapid changes in cardiac stroke volume and pulmonary blood volume. A coefficient of correlation of 0.86 was found following linear regression analysis of the whole material. Analysis of the individual patient showed that the mean coefficient of correlation was 0.94 (range 0.91-0.97), and that the slope of the regression lines was 0.41 to 1.82, and further that the mean intercept was 0.2 ml. It is concluded that impedance cardiography can be employed for measuring the relative intraindividual changes in cardiac stroke volume during the Valsalva manoeuvre, and it is suggested that it may be of use in other situations, such as during haemorrhage or continuous positive pressure ventilation.

Adolescent↗
PubMed1977

Changes in serum lipids during treatment with norgestrel, oestradiol-valerate and cycloprogynon.

The serum concentrations of triglycerides, cholesterol, and free glycerol were determined in 23 climacteric women, before and after the administration of three different steroid drugs. Each drug was given within a period of 12 weeks (3 cycles). Period I: Norgestrel, 0.5 mg daily from the 12th to 21st day of each cycle. Period II: Oestradiol-valerate (Progynon) 2 mg daily from the 2nd to 21st day of each cycle. Period III: Oestradiol-valerate 2 mg from the 1st to 11th day followed by oestradiol-valerate 2 mg+0.5 mg dl-norgestresl from day 12 to 21 of each cycle (Cycloprogynon). A significant decrease in triglycerides was observed following the administration of norgestrel and Cycloprogynon, whereas oestradiol-valerate had no effect on the triglyceride levels. On the other hand, oestradiol-valerate, following a period of norgestrel, produced an increase in serum cholesterol levels.

Adult↗