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Biomedical subjects

N Jäger

Publications and source records attributed to N Jäger.

7 recordsLinked to original sources
PubMed1988

Magnetic resonance (MR) imaging of prostatic tumours, a comparison with X-ray CT and transrectal sonography (TRS).

A total of 7 healthy volunteers and 31 patients have been examined clinically, by MRI, TRS, and biopsy. In those patients with established carcinoma, a CT examination was also performed. For the MRI study, a superconducting MR 2000 imager (Picker International) operated at 0.15 T was used with multiplanar SE and IR sequences. SE sequences with long echo times detected prostatitis, adenoma and carcinoma of the prostate with a high degree of sensitivity. However, at present, differentiation between adenoma, prostatitis and carcinoma is not possible with sufficient accuracy. In these studies we were unable to establish a correlation between the signal pattern and staging and/or grading of the carcinoma. Reliable diagnosis of a prostate carcinoma still requires a biopsy. Because of the high soft tissue contrast and the possibility of selecting any orientation for the plane under investigation, however, MRI represents an improvement in the preoperative diagnosis of local spread.

Aged↗
PubMed1988

[Fibrous polyp of the ureter].

Benign tumors in the upper parts of the urinary tract are rare. The clinical symptoms of flank pain and/or macrohematuria often present problems concerning differential diagnosis. As radiological sign the smoothly bound filling defect with possible ureter obstruction is characteristic but not convincing. Therefore the diagnosis can only be made by operation and a simultaneous histological analysis. This report is based on a female patient with symptoms of flank pain and macrohematuria. By operative exploration a fibrous ureteral polyp was found which was then excised through an ureterotomy.

Female↗
PubMed1987

[Immunologic and functional protein C determination in various internal diseases].

A new practicable and precise functional protein C evaluation test is based on the activation of protein C by a snake venom activator and determination of PC activity by its property to prolong the aPTT in a clotting assay (VK = 1.9% and 4% for intra- and interassay variance respectively). In 40 healthy controls there was a good correlation (r = 0.74) between the functional and immunological (ELISA) evaluation. In 123 patients with both evaluation methods but more pronounced with the measurement of the protein C activity a significant protein C deficiency was found in the patient groups with disseminated solid tumors, inflammatory diseases and myocardial infarction. Besides detection of hereditary PC deficiency Type II (generation of functionally abnormal PC) the functional assay profits by recording PC inhibitor complexes and otherwise dysfunctional PC in DIC. Thus, in patients with hematological neoplasias, only protein C activity was significantly decreases. Decrease of PC activity was more pronounced compared to PC Ag in liver disease indicating synthesis of functionally deficient PC, and in oral anticoagulant treatment due to detection of PIVKA-PC.

Humans↗
PubMed1987

[Results and complications of percutaneous nephropyelostomy in 215 patients].

The results of 242 percutaneous nephropyelostomies in 215 patients were analysed retrospectively. No consideration was given to the experience of the individual operators. There was a total complication rate of 36.4% (mild complications 32.2%, serious complications 34.1%, fatality 0.4%). Rapid reduction in serum creatinine could be demonstrated following drainage in patients in whom renal function had been damaged by obstruction.

Creatinine↗