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Biomedical subjects

N Jaeger

Publications and source records attributed to N Jaeger.

At least 19 recordsLinked to original sources
PubMed1994

Size and status of metastases after inductive chemotherapy of germ-cell tumors. Indication for salvage operation.

Secondary resection of metastases remaining after inductive chemotherapy of advanced germ-cell tumors has thus far been obligatory. The absence of malignant components in one-third of all residual tumors and the high risk of the operation have led several authors to reconsider the criteria for this approach. In a retrospective study of 153 cases (127 evaluable) we investigated the histology of the primary tumor and the size of the residual tumor with regard to residual histology and outcome. Patients were divided into the following three groups according to the histology of the primary tumor: group I, pure seminoma (16 patients); group II, nonseminoma without teratoma (32 patients); and group III, nonseminoma with teratoma (79 patients). Among the 16 purely seminomatous tumors, the residual masses ranged from 2 to 12 cm; 12 consisted of necrotic tissue only, 3 contained malignant germ-cell elements, and 1 contained adult teratoma. The residuals of primarily teratoma-free nonseminomas measured 2-16 cm; the smallest residual tumor containing active malignant elements measured 4 cm, and the diameter of the largest necrotic residue was 6 cm. Four residuals contained mature teratoma. The size of residuals from teratomatous primary tumors was 3-24 cm; the smallest malignant tumor measured 5 cm, and the diameter of the largest purely necrotic mass was 8 cm. According to our results, a secondary operation may be omitted if the residual mass of a primary seminoma is smaller than 5 cm or if that of a primary nonseminoma without teratoma is less than 3 cm in diameter.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

On the necessity of adrenal extirpation combined with radical nephrectomy.

Adrenal metastasis of renal cell carcinoma usually is an autopsy finding and seldom a clinical diagnosis. The incidence of ipsilateral suprarenal gland involvement also can be identified by histological examination of the organ with radical nephrectomy. The necessity of adrenalectomy performed in combination with nephrectomy is discussed. After a retrospective examination of our patients we discovered 8 adrenal metastases among 138 radical nephrectomies. Five patients who also had metastases in the lymph nodes (stages pN1 to pN2) died after an average of 26.4 months. Three patients without lymph node involvement are free of tumor. In these cases routine adrenalectomy must be regarded as a possible curative treatment.

Adrenal Gland Neoplasms↗
PubMed1990

[Nephroblastoma in adults].

Nephroblastoma is very rare in adults and must be differentiated from renal cell carcinoma. The diagnosis can only be made by means of histological examination, which can cause problems because of the various morphological types of the tumor. In this paper an account is given of the authors' experience in the diagnosis and treatment of four Wilms tumors in stages I (n = 1), II (n = 1), III (n = 1) and IV (n = 1) in adult patients. One patient died of a relapse, two patients are taking part in a follow-up study and one patient is undergoing chemotherapy.

Adolescent↗
PubMed1989

Risk/benefit of treating retroperitoneal teratoid bulky tumors.

Inductive polychemotherapy of germinal cell tumors in advanced stages (T0-4N3M0,1) is effective, yet accompanied by serious side effects. Partial remission necessitates resection of the residual tumor. The complications of the salvage operation are tolerable in proportion to its curativity. In a retrospective analysis, we evaluated the occurrence of toxic side effects and the frequency of intra- and postoperative complications in 128 patients with retroperitoneal teratoid bulky tumor. With a follow-up of three to one hundred ten months (means = 43 months), 91 patients (71%) are alive without evidence of disease; 28 patients (22%) died of apparent tumor progression.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[Fluorocytophotometic DNA studies in kidney carcinoma].

DNA measurements in renal cell carcinoma are demonstrating a considerable tumor heterogeneity. Tumor DNA content is one of important prognostic factors. Renal cell carcinomas can be divided into two main groups by single-cell cytophotometry: diploid/near diploid in grade 1 and 2 and mainly aneuploid in grade 3 with variable blocks and peaks. In different tissue samples from the same carcinoma we can found different polymorphism and DNA content.

Adenocarcinoma↗
PubMed1988

[Value of imaging procedures in the diagnosis and staging of bladder tumors].

A retrospective study of 161 patients with carcinomas of the bladder was carried out to assess the value of CT (247 examinations), transurethral sonography (32 examinations), and the early results of MRT. For TA-T3a staging, according to the TNM classification of the IUCC, transurethral sonography was particularly valuable. CT is useful for demonstrating transmural tumour growth (T3b) and organ invasion (T4), involvement of regional lymph nodes and distant metastases. Tumours in the roof of the bladder and at its base are well shown by MR tomography, using multiplanar sections.

Adult↗
PubMed1988

[Risk and benefit of the treatment of bulky retroperitoneal teratoid tumors].

Inductive polychemotherapy of germinal cell tumors in advanced stages (T0-4N3,4M0,1) is effective, but is accompanied by serious side effects. If partial remission occurs, it is necessary to resect the residual tumor. The complications involved in this salvage operation are tolerable in relation to the prognosis. In a retrospective analysis, we evaluated the occurrence of toxic side effects and the frequency of intra- and postoperative complications in 128 patients with retroperitoneal teratoid bulky tumor. After a follow-up period of 3-110 months (mean = 43 months), 91 patients (71%) are still alive with no evidence of disease; 28 patients (22%) have died of apparent tumor progression.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Scintigraphic detection of malignancies with radioactively labelled tumor antibodies. Clinical results based on immunohistochemical research].

69 patients with different tumors (colorectal, melanoma, testicle, ovary, bladder, carcinoid, lungs) were investigated by radioimmunoscintigraphy. The corresponding antibodies or their F(ab')2 fragments against CEA (n = 30), melanoma antigen (n = 25), TPA (n = 6), beta-HCG (n = 5), HMFG-2 (n = 2) and CEA/CA 19-9 (n = 1) were selected on the basis of immunohistochemical investigations of the primary tumors. The precision was 62%, and the number of false-negative findings was 32%. Additional clinical information (detection or exclusion of a suspected recurrence) could be obtained in 22 patients. From these results, it can be concluded that the corresponding tumor antibodies should be selected on the basis of immunohistochemical investigations of the primary tumor before performing radioimmunoscintigraphy to screen for recurrences or metastases.

Antibodies, Monoclonal↗
PubMed1987

The diagnostic significance of magnetic resonance imaging in prostatic tumours.

Looking for better diagnostic methods of prostatic tumours the pelves of 38 males (22 of them suffering from prostatic carcinoma) were examined by magnetic resonance imaging (MRI). This new technique helps to distinguish between healthy and pathological prostatic tissue. It is a non-invasive method, which seems to gain improved significance in the preoperative delineation of prostatic cancer; it is a valuable tool for an accurate preoperative T-staging.

Humans↗
PubMed1987

Reconstruction of the urethra by a tube from a bladder flap during radical retropubic prostatectomy.

Extirpation of a carcinoma-bearing prostate with requisite radicality is occasionally beset by problems with the reconstruction. On the basis of 56 cases, we have found it possible to use a tube from a bladder flap for the reconstruction of the urethra. When cases of neurogenic disorders and thin bladder musculature are excluded before the operation, one can expect normal urodynamic findings postoperatively and a good prognosis.

Humans↗
PubMed1986

Experimental investigations on intracavity sonography. Part 1: Alteration of imaging by variation of the contents of rigid hollow receptacles or isolated porcine urinary bladders.

Multiple artifacts may occur in the diagnostic application of sonography. Occasionally, these may make it difficult to differentiate real tissue structures. In order to investigate the imaging properties of ultrasound in intracavity investigation techniques, we have examined the imaging under different conditions in rigid hollow receptacles as well as in an isolated porcine urinary bladder. A measurable difference of sound conduction depended on the characteristics of the fluid (sound conductor): furthermore, accumulation of air in the hollow space lead to various interfering echos. The importance of a central position of a sound source for obtaining useful sonograms in intracavity ultrasonographic diagnosis was evident.

Air↗
PubMed1986

Experimental investigations on intracavity sonography. Part 2: Alteration of imaging by artificial alterations in the wall of isolated porcine urinary bladders.

Because the determination of the depth of urinary bladder tumors by means of intracavity sonography depends on several factors (tumor size, reflection behavior of the tumor etc.), we checked the imaging of this diagnostic technique in the isolated porcine urinary bladder under various experimental conditions. Different tissues of defined size were fixed on the inner or outer surface of the bladder wall; both the bladder mucosa and the foreign tissue were damaged thermally or by incision. The importance of a limited depth of sound penetration or of a sound shadow depending on the characteristics of the tissue under investigation was revealed; tissue types could not be distinguished unequivocally by the reflection pattern; above all, a sonographic diagnosis of the tumor was not possible in the presence of histo-pathologically detectable tissue changes due to thermal damage.

Adipose Tissue↗
PubMed1986

Value of intravesical sonography in tumor classification of bladder carcinoma.

The possibility of a T classification for bladder carcinoma by intravesical sonography was investigated in a 3-year field study (1982-1985) at the Urological Clinic, Bonn University. In a total of 571 patients with histologically verified bladder cancer, the sonographic classification was compared with the histological T category. There was an agreement of 70.1%. While the infiltration of superficial tumors (above all of large tumors) was frequently overestimated (28.7%), understaging predominated in invasive carcinomas (20.9%). The overall precision of conventional staging techniques was 67%. Ultrasonography showed a marked superiority, above all in infiltrative papillary tumors of low diameter (precision 76% compared to 12% with the conventional T classification). The sensitivity of the method with regard to the detection of tumor infiltration (90%) was also markedly higher than that of earlier techniques (66%). Particularly helpful in the evaluation of more deeply infiltrating tumors, intravesical sonography constitutes a major extension of the diagnostic spectrum for T classification of bladder carcinoma.

Aged↗