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Biomedical subjects

N Joffe

Publications and source records attributed to N Joffe.

At least 37 records · Page 2Linked to original sources

Recurring hyperplastic gastric polyps following subtotal gastrectomy.

Mucosal polyps of the stomach are separated by histologic means into two major groups: (1) hyperplastic (or regenerative) polyps and (2) adenomas, including adenomatous polyps and villous adenoma. Hyperplastic polyps are not true neoplasms, but probably represent a reactive response to some form of mucosal injury. A little known but interesting manifestation of hyperplastic gastric polyps concerns their development, growth, and recurrence in the gastric remnant following subtotal gastrectomy. The clinical, radiologic, and pathologic findings in two cases of recurring symptomatic hyperplastic gastric polyps after subtotal gastrectomy are presented. It is proposed that reflux bile gastritis might have played an important etiologic role in the development of these recurring hyperplastic polyps.

Adult↗

Atypical appearances of benign hyperplastic gastric polyps.

The vast majority of epithelial polyps of the stomach can be divided into two groups: (1) hyperplastic or regenerative polyps, and (2) adenomas. Of the two, hyperplastic polyps are much more common; they are nonneoplastic lesions which are typically asymptomatic, small, smooth-surfaced, and often multiple. Malignant transformation virtually never occurs in this group of polyps. Adenomas are true neoplasms; they are relatively large, have an irregular surface, and show a distinct tendency to undergo malignant transformation. In this paper the radiologic appearances of hyperplastic gastric polyps, with special reference to atypical findings, are discussed and illustrated. It is shown that simple hyperplastic polyps may present any or all of the radiologic criteria suggestive of gastric adenomas or even frank malignancy. Thus, while radiology plays a vital role in the initial detection and followup of gastric polyps, optimum clinical management of the patient is best based on knowledge of the histologic structure of the lesion obtained by endoscopy and biopsy.

Aged↗

Unusual causes of gastrocolic fistula.

1. Three cases of gastrocolic fistula of unusual cause are presented. These include one patient each with carcinoma of the left kidney, gastric lymphoma, and granulomatous colitis. 2. The relationships between the kidneys and gastrointestinal tract are illustrated by a cadaveric cross-section. 3. The wide variety of diseases resulting in gastrocolic fistula is discussed. 4. Careful fluoroscopic and radiographic study may be necessary to detect the site of the fistula and to identify its cause.

Colonic Diseases↗

Localised giant pseudopolyposis secondary to ulcerative or granulomatous colitis.

Pseudopolyps which represent polypoid oedematous tags, regenerating mucosal islands between ulcerations or heaped-up granulation tissue covered by epithelium, are a common sequela of ulcerative colitis and may also occur secondary to granulomatous colitis. Occasionally, a large discrete mass of pseudopolyps occurs simulating a villous-like or polypoid neoplasm and the term 'localised giant pseudopolyposis' has been applied to this phenomenon. In this paper the radiological appearances of localised giant pseudopolyposis secondary to ulcerative or granulomatous colitis are described and illustrated. The differential diagnosis is discussed and four new cases are added to eight previously reported in the literature.

Adult↗

Barium studies in small-bowel infarction. Radiological-pathological correlation.

Seven patients with proved small-bowel infarction were studied to determine whether the radiographic appearance of an ischemic segment is helpful in predicting the severity of the process, in particular the potential viability or nonviability of the affected bowel. It was found that the barium examination is useful in detecting small-bowel infarction in clinically obscure cases but is unreliable in predicting the depth of necrosis or potential viability of an ischemic segment. In addition, the longitudinal extent of ischemic damage was underestimated using the radiographic findings and there was poor correlation between the transit time of barium and the severity of bowel-wall damage.

Aged↗

Transpyloric prolapse of polypoid gastric carcinoma.

Four patients with discrete intraluminal filling defects in the duodenal bulb secondary to transpyloric prolapse of polypoid gastric carcinoma are reported. The lesions were pedunculated in 2 cases and sessile in the remaining 2. The clinical, radiological,and pathological findings are discussed. Prolapsed gastric carcinoma should be included in the differential diagnosis of localized intraluminal filling defects in the duodenal bulb and endoscopy and biopsy performed in patients with appropriate clinical and radiological findings.

Adenocarcinoma↗

Roentgenologic abnormalities of the urinary bladder secondary to Crohn's disease.

Urinary tract symptoms and signs may result from secondary involvement of the urinary bladder in patients with Crohn's disease. In a small but significant proportion of these individuals, urinary tract symptoms represent the initial or predominant mode of presentation. Such patients may be erroneously treated for primary infection of the lower urinary tract for prolonged periods before the intestinal origin of the disease process is discovered. Roentgenologic abnormalities of the urinary bladder may provide early and important clues to the correct DIAGNOSIS. The various abnormalities of the urinary bladder which may occur secondary to Crohn's disease are described and illustrated, and the roentgenologic differential diagnosis is discussed.

Adult↗