Biomedical subjects

N Jonsson

Publications and source records attributed to N Jonsson.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Morphologic changes following nephrostomy track dilatation. An experimental investigation in the pig.

The effect on the renal parenchyma caused by rapid dilatation of a nephrostomy track to 24 F to 30 F was studied on 9 kidneys in 5 pigs. Angiography at different intervals up to 5 weeks was used in combination with histology. Moderate bleeding and short lacerations were observed around the puncture site in all kidneys. Complications included one transient pyelovenous reflux, one organized abscess following perforation of the upper pole, and two cases of hydronephrosis caused by abscess and inflammation. These infections were probably due to the prevailing sanitary conditions. No arteriovenous fistula formation was seen. Minimal scars were encountered after 4 to 5 weeks follow-up. Transparenchymal access to the pelvocaliceal system through percutaneously established large tracks seems to cause limited damage which resolves in minor scars provided perforations are avoided by an optimum technique and infections are prevented or treated appropriately.

Abscess↗

PubMedDate not supplied

Estrogen receptor content in adenovirus type 9-induced rat mammary tumors.

Hormonal factors play an important role in the induction of mammary tumors and tumor-like lesions in adenovirus type 9-inoculated W/Fu rats. Primary Ad 9-induced fibroadenomas contained significantly higher amounts of estrogen receptor (determined by means of enzyme immunoassay) in comparison to normal breast tissue (p = 0.01**) and "spontaneous" fibroadenomas (p = 0.03*), used as control tissues. The receptor content of serially isografted virus-induced fibroadenomas did not differ significantly from the two types of control tissue. The findings suggest that changes in the estrogen receptor level are of importance in the tumor induction process, but also that additional factors are required for the preservation of tumor characteristics as well as for lipoma induction.

Adenoviridae↗

PubMedDate not supplied

Balloon catheter dilatation of stenotic common bile duct anastomoses in the pig. A preliminary investigation.

Fibrotic stenosing anastomoses of the common bile duct were surgically created in pigs in order to investigate the effects of percutaneous transhepatic balloon catheter dilatation. In a group of 6 animals, not treated with balloon dilatation, percutaneous transhepatic cholangiography and microscopic examination of the stricture were performed 5 to 25 weeks postoperatively. A persistent stenosis and slight to moderate fibrosis of the bile duct wall and peribiliary tissue were observed. In 5 animals the stenotic anastomosis was dilated 4 to 10 weeks postoperatively and this resulted in widening of the stricture and necrosis of the mucosa at the stricture site. Rupture of the fibrotic tissue in the bile duct wall and thrombus formation in the peribiliary veins also occurred in one of these 5 animals. Short-term follow-up in 3 animals 4 to 6 weeks after balloon dilatation showed almost complete fibrotic healing and partial re-stenosis of the anastomoses.

Animals↗