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N Juul

Publications and source records attributed to N Juul.

At least 37 records · Page 2Linked to original sources
PubMed1990

Surecut 0.6 mm liver biopsy in the diagnosis of cirrhosis.

Liver biopsy with the 0.6 mm (23 gauge) Surecut needle was compared to conventional Menghini biopsy in the diagnosis of cirrhosis. Seventy-seven consecutive patients (mainly alcoholics) with a clinical indication for liver biopsy had both biopsies performed simultaneously. In 71 patients sufficient material for a morphological diagnosis concerning liver architecture was obtained with both biopsy techniques (Surecut insufficient in 5 cases and Menghini insufficient in 2 cases). The biopsies were classified as cirrhosis or non-cirrhosis. There was agreement in 69 cases (97%, confidence limits 90-100%). Using the result of the Menghini biopsy as the final diagnosis, the predictive values for a positive and negative diagnosis for the Surecut needle were 96% and 98%, respectively. There were no complications to either of the biopsies. It is suggested that the 0.6 mm Surecut biopsy may be used in the diagnosis of cirrhosis in cases where conventional Menghini needle biopsy is contraindicated.

Biopsy, Needle↗
PubMed1990

Ultrasonically guided percutaneous treatment of liver abscesses.

Twenty-two patients with liver abscesses demonstrated by ultrasonography (US) were treated over a nine-year period. The diagnosis was in all cases verified by puncture. The patients were treated by US-guided puncture or catheter drainage. Seventeen patients (77%) were cured without surgical drainage. Four patients were cured after subsequent surgical intervention. One patient died later of pancreatic carcinoma. There were no complications from the US-guided therapy. For the treatment of liver abscesses we recommend US-guided drainage as the first choice. Close collaboration between surgeon and radiologist is mandatory since some of these patients still need surgical treatment.

Drainage↗
PubMed1989

Ultrasonically guided 125iodine seed implantation with external radiation in management of localized prostatic carcinoma.

Thirty-three patients with localized prostatic carcinoma (16 poorly differentiated) were treated with transperineal 125Iodine seed implantation (160 Gy) guided by transrectal ultrasonography and subsequent external beam irradiation (47.4 Gy). The observation time was six to sixty-eight months with a median follow-up of thirty-five months. Median change in prostatic volume was a reduction of 35 percent. Re-biopsy or transurethral resection of the prostate was performed in 25 patients after one to two years, revealing still malignant histology in 12 (48%). Development of distant metastases occurred in 14 patients (44%), and 8 have died of prostatic cancer. Fourteen patients suffered from late complications of which surgical intervention was indicated in 3 cases.

Aged↗
PubMed1989

Abdominal ultrasound versus intravenous urography in the evaluation of infravesically obstructed males.

In a prospective study intravenous urography (IVP) and abdominal ultrasonography (US) were compared in 100 consecutively admitted male patients with symptoms of infravesical obstruction. No pathology was found in 67 patients on IVP and in 61 patients on US. Both modalities disclosed 5 bilateral, 4 unilateral hydronephroses and one patient with contracted kidneys. IVP found 7 renal masses: one solid tumour, 2 "possibly solid" tumours and 4 "possibly cysts", whereas US found one solid tumour and 16 cysts. Both modalities detected 3 kidney stones, 5 bladder stones and 3 bladder tumours. It is concluded that "imaging" of the urinary tract is only indicated in cases of haematuria, elevated creatinine, history of renal calculous disease and other clinical suspicion of upper urinary tract disease. It is further concluded that US is preferable to IVP in this patient category due to (1) better characterization of renal masses, (2) the possibility of investigating the liver and the retroperitoneum in the same setting, (3) better evaluation of the prostate with respect to size, (4) better evaluation of the bladder, and (5) last but not least for economical reasons. However, bone metastases will be missed.

Humans↗
PubMed1988

Tetracycline for sclerosis of thyroid cysts. A randomized study.

In a prospective study, 53 consecutive patients with solitary thyroid cysts were randomized to ultrasonically guided cyst aspiration and subsequent flushing with isotonic saline (n = 30) or tetracycline hydrochloride (n = 23). The patients were followed up clinically and ultrasonically 1, 3, 6, and 12 months after treatment. If the cyst recurred, a repeated treatment was offered. Cure was defined as the absence of any residual nodule and an ultrasonic cyst volume of less than 1 mL 12 months after the last treatment. During follow-up, two patients without recurrence after saline treatment and six patients without recurrence after tetracycline treatment developed solid cold nodules. Fourteen (47%) of 30 patients in the saline group and ten (43%) of 23 patients in the tetracycline group were cured (not statistically significant). Tetracycline does not seem to offer any advantage over isotonic saline in the treatment of thyroid cysts, and some of these patients still need thyroid surgery.

Cysts↗
PubMed1988

The long-term influence of vasectomy on prostatic volume and morphology in man.

During the past two decades several papers have described the changes in prostatic secretory capacity following vasectomy. Based upon results indicating a reduction of secretory function, it was suggested that even prostatic size and the incidence of benign prostatic hyperplasia (BPH) might be altered after the operation. In this study, which included 56 males who had been vasectomized 8 years previously and 56 age-matched control persons, transrectal ultrasonic scanning of the prostate was used for exact measurements of the prostatic volume and for the investigation of intraprostatic echo pattern. The total prostatic volume, the volume of the periurethral gland, and the volume of the peripheral zone were not influenced by the vasectomy; nor was the growth rate of these zones affected. In the vasectomy group, the frequency of adenomatous prostates was 19.6%, whereas 30.3% of prostates in the control group had ultrasonic signs of BPH. However, this is not a statistically significant difference. Subdividing the material according to age did not reveal altered BPH frequency in any age group when vasectomized and controls were compared.

Humans↗
PubMed1988

The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas.

DNA content was measured by flow cytometry in isolated nuclei from 71 neoplastic nodules and 15 hepatocellular carcinomas isolated from rat liver at various times after treatment with an initiation--promotion regimen employing diethylnitrosamine and 2-acetylaminofluorene. Nodules and carcinomas contained mostly diploid nuclei as compared with both surrounding and normal hepatocytes which were predominantly polyploid. There appears to be a positive correlation between the degree of diploidy in nodules and their rate of proliferation. No aneuploid populations were identified in any neoplasm despite good peak resolution. These results show that an alteration in proliferation pattern from normal polyploidizing growth to diploid--diploid divisional growth is a consistent characteristic throughout the carcinogenic process in our experimental model.

2-Acetylaminofluorene↗
PubMed1988

Bladder tumor staging by transurethral ultrasonic scanning.

To determine tumor stage, 115 bladder cancer patients with cystoscopic suspicion of invasion underwent transurethral ultrasonic scanning. Seventeen patients who had received radiotherapy were excluded because it proved impossible to differentiate between tumor and irradiation sequelae. Of the remaining 98 examinations, 4 (4.1%) were inconclusive, 73 tumors (74.5%) were correctly staged, 16 tumors (16.3%) were overstaged and 5 tumors (5.1%) understaged. Transurethral ultrasound is regarded a useful supplement to cytoscopy and biopsy in staging of bladder tumors suspected of invasion.

Biopsy↗
PubMed1988

Ultrasound-guided percutaneous nephrostomy in the treatment of advanced gynecologic malignancy.

Adjuvant to cancer therapy, 35 percutaneous ultrasound-guided nephrostomies have been applied in 21 patients with ureteral occlusions or lesions secondary to advanced gynecologic malignancies. Application of the catheters was uncomplicated. Dislodgement of the catheters was the major problem with this technique, occurring in 9 cases. There were no serious complications. In 14 patients, normal ureteral function was restored after the cancer therapy, 2 had to be nephrectomized, and in 5 patients the nephrostomies had to remain permanently. It is concluded that nephrostomy is a useful tool in the management of advanced gynecologic malignancies in patients who have a prospect of cure or a period of meaningful tumor regression.

Female↗
PubMed1988

Transrectal prostatic ultrasonography. Equipment, normal findings, benign hyperplasia and cancer.

The principles of transrectal ultrasound scanning of the prostate and current imaging facilities are reviewed. The ultrasonic anatomy of the normal prostate is described and illustrated. Exact volumetric determination of the gland is discussed, and the ultrasonic presentation of benign hyperplasia is surveyed. Ultrasonography is useful in the diagnosis of prostatic cancer and in T-staging the tumours. Ultrasonically guided needle biopsy of the prostate is an important component in cancer diagnosis. An aim for ongoing technical developments should be detection of prostatic cancer before it becomes palpable.

Humans↗
PubMed1988

Ultrasonic evaluation of age-related human prostatic growth and development of benign prostatic hyperplasia.

In 175 normal men aged 27-70 (median 40) years, the prostate was ultrasonically scanned by the transrectal route. Ultrasonic signs of adenoma were found in 26%. The earliest age at which signs of benign prostatic hyperplasia appeared was 27 years, and the incidence increased with age. Adenomatous prostates were significantly larger than nonadenomatous, with median volume 28.0 (14.5-62.1) ml versus 23.0 (11.3-39.1) ml (p less than 0.0005). The adenomatous prostates also had a larger median volume of the periurethral gland (4.1 ml vs. 3.0 ml; p less than 0.0005) and a larger peripheral zone (23.3 ml vs. 20.2 ml; p less than 0.005). The total prostatic volume increased statistically significantly with age and the growth rate was calculated to be 0.81 %/year +/- 0.25 (S.E.) corresponding to 0.2 ml/year. The growth rate of the periurethral zone was 1.5 %/year +/- 0.5 (S.E.). Volumetric correlation between periurethral gland and total prostatic volume depended on whether or not adenoma had developed. Prostatic volumes measured in vivo by ultrasound are slightly greater than values obtained at autopsy.

Adult↗
PubMed1987

Electron microscopy of ultrasound-guided fine-needle biopsy specimens.

A prospective 3-year study was undertaken in order to assess the value of electron microscopy (EM) as a supplement to routine light microscopy (LM) in ultrasound-guided fine-needle biopsy of suspected abdominal and retroperitoneal tumours. Eight-six of the 899 ultrasound-guided fine-needle biopsies performed during this period were supplemented with EM using the following indications: metastatic lesions with unknown primary tumour, primary retroperitoneal tumours, tumours with atypical clinical histories and where the primary LM evaluation was unable to determine tumour cell type. Two methods of obtaining material for EM were tested, namely, fine-needle aspiration and fine-needle histological biopsy (Surecut). Both methods yielded suitable material for EM evaluation in approximately 80% of the 76 cases where tumour cells were identified by LM. However, it was technically easier to process material for EM when obtained by fine-needle histological biopsy. The results of the 62 cases where suitable material for EM was obtained were grouped according to the histopathological and clinical value of the diagnosis. In 23 cases (37%) EM was without additional diagnostic value. In 12 cases (19%), EM supplied a more precise histopathological diagnosis, but the diagnostic gain was without clinical significance. In 27 cases (44%) EM was of significant clinical value, as the diagnosis by itself was enough to change the investigative procedure and/or the treatment of the patient.

Abdomen↗
PubMed1987

Ultrasonographic diagnosis of renal stones.

To illucidate the diagnostic accuracy of ultrasound in the detection of renal stones we performed a blind comparative study of ultrasonography and i.v. urography. In 92 kidneys with 58 stones, 10 stones smaller than 6 mm were overlooked by ultrasound, whereas all stones 6 mm or larger were correctly detected. In one case of uric acid stone disease i.v. urography was inconclusive in determining the true nature of a renal pelvic filling defect, whereas ultrasound correctly diagnosed a stone. We conclude that ultrasonography has a place in diagnosis and control of renal stones.

Humans↗
PubMed1986

Bladder tumour control by abdominal ultrasound and urine cytology.

A blind study comparing abdominal ultrasound and cystoscopy was carried out in 186 patients. 20 bladder tumours sized from 2 to 5 mm were overlooked. Combination with urine cytology increased the diagnostic sensitivity. In order to reduce costs and patient inconvenience in the bladder tumour control population abdominal ultrasound and urine cytology is advocated as an alternative to cystoscopy. This control modality seems safe in patients with "low-risk" bladder tumour disease.

Cystoscopy↗
PubMed1985

Ultrasonically guided fine needle aspiration biopsy of renal masses.

A consecutive series of 301 ultrasonically guided fine needle aspiration biopsies of renal masses was reviewed. The retrieval rate was 95 per cent and a correct cytological diagnosis was established in 82 per cent of the cases. There were 14 false positive aspirates, for a predictive value of a malignant aspirate of only 93 per cent. All false positive results were misinterpreted as relatively well differentiated adenocarcinoma. We conclude that renal fine needle aspiration biopsy may add information but the risk of a false positive finding must always be considered.

Biopsy, Needle↗
PubMed1985

Comparison of ultrasonography and transhepatic cholangiography in the evaluation of obstructive jaundice.

The diagnostic value of ultrasonography and percutaneous cholangiography was compared in 114 consecutive patients with obstructive jaundice. The final diagnosis was obtained by surgery or autopsy. Transhepatic cholangiography diagnosed obstruction and its level in all patients, whereas ultrasonography failed to find obstruction in 3 patients and was unable to determine the level in 11 patients. The cause of obstruction was correctly assessed in 106 patients by transhepatic cholangiography and in 74 by ultrasonography. In 15 patients with obstruction caused by common duct calculi ultrasonography only diagnosed the five, and in 9 patients malignant obstruction was diagnosed as calculi. Ultrasonography is a reliable tool for diagnosis of obstructive jaundice and in most cases for localisation of the level of the obstruction. However, diagnosis of the cause of obstruction and of its precise topography requires direct cholangiography.

Adult↗