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Biomedical subjects

N K Barkov

Publications and source records attributed to N K Barkov.

At least 19 recordsLinked to original sources
PubMed1985

A study of the mediator spectrum of delta-9 tetrahydrocanabinol effects on cerebral bioelectric activity.

Defense conditioning in cats with simultaneous recording of bioelectric activity was used to show that serotonin-negative and dopamine-positive substances normalize delta-9 THC-elicited dissimilarity of amplitudinal and temporal parameters of evoked potentials in visual associative and somatosensoric zones II of the cerebral cortex. It was also found that serotoninergic substances affect both primary and secondary waves of evoked potentials while dopaminergic substances influence only late waves.

Animals↗
PubMed1983

Mediator mechanisms of cathinone effects on animal behaviour.

The effect of cathinone on the visual differentiation of cats was investigated by the method of defense conditioned reflexes. It was found that cathinone decreases the differentiation of both the short-term and prolonged visual stimuli. These effects of cathinone increase when the serotoninergic system is activated and decrease under dopaminergic system activation.

Alkaloids↗
PubMed1983

[Features of the effects of apomorphine on rats of different sexes preferring ethyl alcohol].

The influence of apomorphine (1 mg/kg/day subcutaneously) on the behavior and some pharmacokinetic parameters of both male and female rats preferring ethanol to water was studied experimentally. Upon withdrawal of ethanol, apomorphine decreased the time of transmission to water consumption in the rats of both sexes and prevented a decline in the endogenous ethanol levels, the latter effect being especially pronounced in the female rats. Investigations on the "Animex" actograph showed an intensified response to apomorphine in rats preferring ethanol, with female rats displaying a greater change in the response. Under conditions of a renewed access to ethanol, apomorphine increased the time of the restoration of the previous preference for ethanol to water (with a stronger effect seen in females) and lowered the rate of ethanol elimination from the blood (in the female rats exclusively). The effacement of the sex differences in ethanol addicted rats, and a greater damaging impact of ethanol on female rats are emphasized.

Alcoholism↗
PubMed1982

[Ethanol pharmacokinetics in narcotic action and endogenous ethanol in female rats].

Experiments were made on female rats to demonstrate a positive correlation between the time of ethanol anesthesia in estrus and diestrus and (1) subsequent preference of ethanol to water (r = 0.68) and (2) ethanol consumption dosage (r = 0.72). In the same rats (during estrus and diestrus), the endogenous level and blood concentrations of ethanol were measured 30 minutes after administering the anesthetic dose (4.5 g/kg) and during the animal's "egress" from anesthesia. The low level of endogenous ethanol and rapid decrease of the blood ethanol concentration upon administering the anesthetic dose during estrus were characteristic of those female rats which, under the conditions of free choice, preferred ethanol to water and consumed it in large doses.

Alcohol Drinking↗
PubMed1981

The effect of neuroleptics, tranquillizers, narcotics, antidepressants and anticonvulsive drugs on the alterations of mouse behaviour caused by acetaldehyde.

In a study of the effect of 26 psychoactive drugs on the complex of mouse behaviour changes caused by acetaldehyde it was found that tranquillizers, hypnotics, sodium oxybutyrate and ethanol are the most efficient. The differences in teh drug effects were determined by a tan alpha criterion. Antidepressants and neuroleptics have equal tan alpha, whereas narcotics, anti-convulsive drugs and tranquillizers all have similar tan alpha, but greater than that of the antidepressants and neuroleptics. A direct dose/effect relationship was found to exist for all the drugs investigated except for neuroleptics and antidepressants. For the latter drugs an increase in dose is followed by an increased effect, which, however, decreases on further increase of the dose. The convulsive syndrome is completely abolished only by tranquillizers and narcotics. Our results are quite in agreement with clinical data about the effectiveness of psychoactive drugs in the treatment of the alcohol abstinence syndrome. The method can be used not only for screening purposes, but also to define the specificity in the action of antialcoholic drugs.

Acetaldehyde↗
PubMed1980

The role of testosterone in the development of experimental alcoholism.

The hormonal effects of testosterone, progesterone and extradiol on voluntary preference of ethanol were investigated in experiments carried out on castrated male albino rats. It was observed that testosterone stimulated the development of ethanol preference, while the effects of progesterone and estradiol were significantly slower and less intensive. It was also observed that the androgenic action of testosterone was more important than its anabolic action in stimulating ethanol preference.

Alcohol Drinking↗
PubMed1976

[The character of the effect of triftazin, carbidine and aminazine on defensive conditioned reflexes].

The author studied in chronical experiment on the rats the influence of triphtazine, karbidine and aminazine on the conditioned reflexes with the irritation of the mesencephalitio part of the reticular formation. The obtained data confirm the inhibitive influence of aminazine on the mesencephalitic part of the reticular formation. Triphtazine and karbidine, alike aminazine, prevent the inhibition of the defensive conditioned reflexes due to the irritation of the mesencephalitis part of the reticular formation testifies to the fact of their inhibitive influence on these structures.

Animals↗
PubMed1975

[Effect of carbidine on conditioned defense reflexes].

Chronic experiments were conducted on rats and rabbits; a study was made of the effect of carbidine on the conditioned defence reflexes in stimulation of the mesencephalic part of the reticular formation. Carbidine prevented the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. This pointed to its depressive influence on the mentioned structures, and was confirmed by experiments on rabbits in recording changes in biocurrents under conditions of stimulation of the mesencephalic reticular formation.

Animals↗
PubMedDate not supplied

[The withdrawal syndrome and lipid peroxidation during the chronic administration of narcotic analgesics to rats].

Diverse behavioral disorders and the intensity of lipid peroxidation (LPO) of biological membranes were estimated in different rat tissues after the 7-day administration and subsequent withdrawal of morphine or promedol. 24 hours after the withdrawal of the analgetics the demonstrated a high initial level of motor activity in the open field. Naloxone, an antagonist of opiate receptors, potentiated motor activity and the intensity of withdrawal syndrome (by 160%) in rats with morphine rather than promedol dependence. The behavioral disorders in dependent animals were accompanied by LPO activation in liver and brain membranes.

Analgesics, Opioid↗
PubMedDate not supplied

[The "phenomenon of ethanol preference"].

The problem of using the "phenomenon of ethanol preference" under conditions of a free choice between ethanol and water as a behavioural model of alcoholism is discussed. The methodical aspects of the model are considered: the regimen of the animals' keeping, the criteria of preference, the concentrations of ethanol solutions, the schedule of presentation of the solutions. There was shown the principal similarity between the changes in the behaviour and biological parameters of the animals preferring ethanol and the changes observed in the man suffering from chronic alcoholism. It is concluded that despite the imperfection of the model the "phenomenon of ethanol preference" remains fairly valuable for studying the etiopathogenesis of alcoholism and developing the methods of the therapeutic action on the patient.

Alcohol Drinking↗
PubMedDate not supplied

[Feasibility of applying pattern recognition techniques in psychopharmacology].

The necessity to consider the effect of psychotropic agents on the human organism as on the integral system interrelated with the environment is grounded. The need of applying the pattern recognition theory techniques which allow to analyze the integral state of the organism is substantiated. An illustration of the analysis of a psychotropic agent cathinone by using these techniques is presented.

Alkaloids↗