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Biomedical subjects

N K Chereĭskaia

Publications and source records attributed to N K Chereĭskaia.

At least 19 recordsLinked to original sources
PubMed2005

[Gastroesophageal reflux disease and respiratory apparatus pathology: the evidence of interrelation and unsolved problems].

The article deals with interrelation between gastroesophageal reflux disease (GERD) and bronchial asthma (BA), presenting the results of the examination of 37 patients, who underwent 24-hour intraesophageal ph-metry and bronchial passability in addition to standard tests, used in patients with BA. Concomitant GERD was revealed in 45.94% of the patients with BA, and esophagitis signs--in 5.4% of the patients, which shows that endoscopically negative forms of GERD are more prevalent among patients with BA. Treatment with proton pump inhibitors did not result in complete regression of the clinical manifestations of BA. In the authors' opinion, even casual-effect relation between bronchial obstruction attacks does not always suggest that GERD is the cause of the illness. Most likely, GERD is one of many triggers provoking BA attacks. Thus, the term "reflux-induced BA" is irrelevant.

Adult↗
PubMed2003

[Glucocorticoid adrenal function and clinical implications of hydrocortisone metabolism tests in patients with bronchial asthma].

A glucocorticoid adrenal function was studied in 42 perimenopausal women with bronchial asthma (BA) by radioimmunoassay estimation of blood hydrocortisone levels, free and conjugated fractions of urinary hydrocortisole, 24-h excretion of overall 17-OCS and hydrocortisone metabolism index. Replacement estrogens inhibit processes of microsomal hydroxylation and reduce clearance of the introduced steroids. Replacement therapy with sex hormones conducted to correct menopause had no negative influence on hydrocortisone blood levels and its metabolism.

Adult↗
PubMed2002

[Integrative study of bronchial asthma in perimenopausal women].

The paper presents results of complex study of the specific features of the course of bronchial asthma (BA) in the peri- and early postmenopausal periods, including investigations of hormonal and immunological statuses, bone tissue mineral density and blood lipids, and evaluates the effects of peri- and early postmenopause and climacteric syndrome of varying severities on the course of BA. A drug test using estrogens has been developed to evaluate their effects on bronchial airflow. It has been shown that estrogens do not negatively affect bronchial airflow in most patients with BA in the peri- and early postmenopausal periods. The efficiency of replacement hormone therapy with estrogen-progestogen drugs has been for the first time estimated in these patients. Treatment with the estrogen-progestogen drug clinonorm increases the effects of endogenous cortisol, which makes it possible to reduce a dosage of glucocorticosteroids and to increase the mineral density of bone tissue.

Adult↗
PubMed2002

[Macro- and trace elements of blood in elderly patients with bronchial asthma].

Using the method of roentgen fluorescent analysis a study was carried out on the content of macro- and trace elements (ferrum, zink, sulfur, potassium, calcium) in whole blood and serum of 62 women with bronchial asthma (BA) depending on severity of the disease and performed therapy. The study revealed a disrupted content of studied chemical elements in serum and whole blood of patients having BA of various severity: reduction in the level of sulfur and potassium and increase of ferrum and zink proportionally to the severity of process. At the same time calcium ions redistributed from serum to blood cells. A high concentration of chemical elements in whole blood was observed in patients who had received systemic glucocorticoids (GC) as basic therapy compared with patients treated with inhalation GC.

Anti-Inflammatory Agents↗
PubMed2001

[Immune and interferon system in patients with bronchial asthma].

We studied the levels of acute inflammation phase proteins (AIPP), production of alpha, gamma and serum interferons, the activity of epsilon-receptors of T-lymphocytes in 39 patients with bronchial asthma (BA). Correlations were made with the process severity and basic therapy. We discovered imbalance of immunoregulatory mechanisms: enhanced AIPP synthesis, low production of induced alpha and gamma interferons, elevated concentrations of poor-differentiated T-lymphocytes. This confirms persisting inflammation in BA.

Asthma↗
PubMed1999

[Specific aspects of the course of bronchial asthma therapy in perimenopausal period].

Bronchial asthma (BA) course and menopausal features were studied in 58 perimenopausal women. Effects of menopause on BA clinical manifestations were considered. 19 patients on climonorm therapy were examined immunologically. It was found that premenopause and perimenopause deteriorate BA clinical picture whereas hormone replacement therapy with climonorm produce a positive effect on menopause and BA. In long-term hormone treatment it is necessary to follow up immune status.

Administration, Inhalation↗
PubMed1999

[Early diagnosis of ischemic heart disease in patients with chronic obstructive pulmonary diseases].

AIM: To study incidence rate, course features, principles of diagnosis and therapy of ischemic heart disease (IHD) in patients with chronic obstructive pulmonary diseases (COPD). MATERIALS AND METHODS: Standard clinical examinations, ECG, chest x-ray, echo-CG, 24-h Holter monitoring, coronarography were performed in 60 patients over 40 years of age with bronchial asthma or chronic obstructive bronchitis. Autopsy data were analyzed for 20 patients who died of COPD. RESULTS: IHD was diagnosed in 53.3% of the examinees. 70% of the patients treated with preductal (trimetasidine) benefited from the treatment: they had less frequent episodes of painless myocardial ischemia. Autopsy material has shown that COPD patients frequently suffer of aortic and coronary atherosclerosis. CONCLUSION: IHD diagnosis in COPD patients is rather difficult as there are no well-defined correlations between clinical picture of IHD and data of device investigations, IHD is painless more frequently than in general population (in 84.4% of patients in this study). Preductal is a drug of choice for treatment of IHD in COPD patients.

Adult↗
PubMed1999

[Treatment of arterial hypertension in patients with bronchial asthma].

Treatment of arterial hypertension in patients with concurrent chronic obstructive diseases of the lungs has limits in prescription of antihypertensive drugs. STAMLO--long-acting calcium antagonist--is proposed for monotherapy of mild and moderate hypertension in patients with bronchial asthma. The drug decreases hypertension in the greater and lesser circulation, improves bronchial permeability.

Adult↗
PubMed1998

[Problems of psychosomatics and somatopsychiatrics in internal medicine].

The past 2 decades in our country has been marked by the population's poorer health status, the obvious tendency for the incidence of many somatic and mental diseases to increase. The problem of somatogenic mental diseases and disorders diagnosed in the presence of a somatic disease merits particular attention. The paper considers the background of psychosomatics and somatopsychiatrics, presents the authors' own findings of the mental status in patients with chronic lung diseases. Various somatic disease-detected psychopathological syndrome relationships most common in the treatment of visceral diseases are systematized. Emphasis is laid to the fact that the differentiation of proper mental and somatic diseases, the elaboration of the optimal treatment policy is possible only if therapeutists work in close cooperation with psychiatrists. Principles in the complex therapy of psychopathological disorders in patients with somatic diseases are given.

Humans↗
PubMed1994

[Effect of transcutaneous stimulation of diaphragm on systemic and central hemodynamics in patients with chronic bronchitis].

25 males and 5 females suffering from chronic obstructive bronchitis (COB) underwent transcutaneous diaphragmatic electrostimulation (TDE). As shown by central intrapulmonary hemodynamics, those patients who had no circulatory decompensation benefited from TDE. There was a decrease in the pulmonary hypertension, intensification of general hemodynamics, reduced tonicity of the pulmonary arteriolar bed, improvement of right ventricular function. In circulatory decompensation TDE may cause deterioration of right ventricular function, enhancement of circulation decompensation against unchanged pulmonary hypertension and pulmonary-arteriolar tonicity. The changes in pulmonary artery pressure, total pulmonary vascular resistance, pulmonary-arteriolar elasticity observed after a single TDE session may prompt the validity of further COB treatment according to the above regimen.

Adolescent↗
PubMed1991

[Pulmonary hypertension in chronic lung diseases].

The article provides data on the pathogenesis, hemodynamics and the contractile function of the myocardium in chronic diseases of the lungs aggravated with pulmonary hypertension. The data were based on complex clinical and instrumental examinations, including catheterization of the right segments of the heart with endomyocardial biopsy, rheography of the pulmonary artery, radiocardiography, radionuclide ventriculography. A three-stage stratification of pulmonary hypertension was proposed. The data are essential in assessments of occupational bronchial disorders, their prevention and treatment. A set of measures, both preventive and curative, was also proposed.

Blood Pressure↗
PubMed1991

[Study of myocardial morphology in chronic obstructive bronchitis complicated by pulmonary hypertension based on the results of endomyocardial biopsy].

Endomyocardial biopsy along with right heart catheterization was first performed in 12 patients with chronic obstructive bronchitis complicated by transient or sustained pulmonary hypertension. Light and electron microscopic findings showed signs of severe myocardial dystrophy in 7 patients and prevalent hypertrophy in the remaining patients. Endomyocardial biopsy provided valuable information on the state of the myocardium, yielding evidence for the heretogeneous nature of right ventricular myocardial changes. Two morphological variants of cor pulmonale--hypertrophic and dystrophic--could be identified with regard to the findings.

Biopsy↗
PubMed1991

[Myocardium in chronic obstructive lung diseases].

The analysis of endomyocardial biopsies (10 specimens) and clinical observations suggests the conclusion: myocardial lesions in OPD patients with pulmonary hypertension are due to metabolic and hemodynamic disturbances. In addition to myocardial hypertrophy, myocardial dystrophy contributes to development of cor pulmonale.

Biopsy↗
PubMed1991

[Hemodynamics and myocardial contractile function in patients with chronic obstructive bronchitis complicated by pulmonary hypertension].

Eighty patients with chronic obstructive bronchitis complicated by stable pulmonary hypertension were examined for the general, central, intracardial hemodynamics and myocardial contractile function. In addition to the general clinical examination, use was made of tetrapolar rheography, rheography of the pulmonary artery, radiocardiography, radionuclide ventriculography. The majority of the examined manifested hemodynamic disorders both in the pulmonary and greater circulation together with abnormalities of myocardial contractile function of the right and left ventricles. The methods employed were shown to be of high information content.

Bronchitis↗