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Biomedical subjects

N K Das

Publications and source records attributed to N K Das.

At least 19 recordsLinked to original sources
PubMed2003

Reduction of mechanical heart valve thrombosis through a clinical audit.

BACKGROUND AND AIM OF THE STUDY: Patients with mechanical heart valves implanted at four cardiothoracic centers were followed up in a hospital in Eastern India. Despite successful surgery and regular hospital visits, long-term survival was compromised by anticoagulation-related complications. METHODS: Systematic analysis revealed under-anticoagulation in most patients. Thrombosis risk in 80 patients on regular follow up from 1989 to 1997 was 8.68 per 100 patient years (pt-yr). The incidence of both thrombotic and bleeding complications was reported as less than two per 100 pt-yr, when prothrombin time was consistently in the range of INR 2.5 to 3.9. In targeting this low event rate, impediments to optimum anticoagulation in the local set-up were identified. International Normalized Ratio (INR) was introduced to report prothrombin time (PT). Patients and doctors were educated about drug and diet interactions with oral anticoagulants (OAC) and the early features of valve thrombosis. Treatment protocols were evolved. The impact of the remedial measures was studied in 81 patients (64 old, 17 new) over a total of 254 pt-yr of follow up, from 1998 to 2001. RESULTS: Thrombosis risk was reduced from 8.68 to 5.12 per 100 pt-yr, while non-fatal bleeding events increased from 0.28 to 1.96 per 100 pt-yr. Due to early recognition of occlusive prosthetic valve thrombosis and institution of fibrinolytic therapy, fatal events were reduced from 3.8 per 100 pt-yr to none for four consecutive years (statistically significant at 99% CI). CONCLUSION: The clinical audit proved to be a valuable tool for understanding the problems in health care delivery, and bringing about improvement.

Administration, Oral↗
PubMed2002

Renal artery involvement in patients of coronary artery disease undergoing coronary angiography--a prospective study.

METHODS: We prospectively studied the angiographic incidence of renal artery stenosis in 1000 consecutive patients who underwent coronary angiography for clinically suspected coronary artery disease since December, 1998. Selective renal arteriography was performed in all the patients (mean age 57 years, 74.6% males) after coronary angiography. RESULTS: Systemic arterial hypertension was present in 52%, 29.1% were smokers, 21% had diabetes and 31.2% had hypercholesterolemia. Significant coronary artery diseases was found in 849 (84.9%) patients. Of the total patient cohort, 103 (10.3%) patients had renal artery disease; 78 (7.8%) had insignificant stenosis (> 50%) and significant renal artery stenosis (< 50%) was identified in 25 (2.5%) patients. Three had bilateral renal artery stenosis. Comparisons were made between renal artery stenosis and risk factor profile. There was no statistically significant association between renal artery stenosis and parameters like diabetes mellitus, hypertension, smoking, lipid levels and serum creatinine. CONCLUSION: In our study, the absolute number of cases with significant renal artery stenosis is small, so no statistical analysis could be performed to demonstrate the relationship of presence of renal artery stenosis with severity of CAD. However patients with severe coronary artery disease or having multiple risk factor showed a trend towards increased prevalence of renal artery stenosis, hence renal angiography should be done for this subset of patients.

Coronary Angiography↗
PubMed1999

Coil embolization of a giant atherosclerotic coronary artery aneurysm.

The incidence of the coronary artery aneurysm varies from 1.5-5%. Atherosclerosis is the most common cause of coronary artery aneurysm in adults. A discrete, giant, saccular atherosclerotic coronary artery aneurysm in an artery without significant proximal stenosis is rare. We report the first such case of a giant atherosclerotic coronary artery aneurysm successfully treated with coil embolization.

Adult↗
PubMed1998

Balloon mitral valvuloplasty with bifoil catheter: immediate and long-term follow-up results.

This report documents clinical and hemodynamic benefits of balloon mitral valvuloplasty (BMV) using a bifoil balloon catheter from a single center in 415 consecutive cases of rheumatic mitral stenosis (MS). The procedure was successful in 396 (95.2%) patients, with an increase in mitral valve area (MVA) from 0.82+/-0.35 cm2 to 2.21+/-0.24 cm2 (P < 0.001). There were 2 (0.48%) in-hospital deaths, and 6 (1.44%) patients developed acute mitral regurgitation. The procedural and fluroscopy time was reduced significantly from 52+/-11 and 38+/-6 min to 33+/-7 and 19+/-5 min, respectively, after modifications of technique in our last 326 cases. The bifoil balloon catheter technique is safe and effective, and provides excellent hemodynamic benefits which are sustained at long-term follow-up. This technique should be considered as an addition to the existing armamentarium of interventional cardiologists performing mitral balloon valvuloplasty.

Adolescent↗
PubMed1991

A University of California State-supported AIDS research award program--a unique state and university partnership in AIDS research.

This article describes the State-supported University of California AIDS research award program and its major accomplishments. It shows how a partnership between a University and a State resulted in the formation of a successful, efficient, and cost-effective AIDS research award program. This program provides funds for rapid testing of investigator-initiated meritorious research ideas, new drugs, and treatment modalities. Funds were also utilized to establish three AIDS Clinical Research Centers, which evolved into regional consortia that coordinate trials of new drugs and other modalities. This program succeeded in involving investigators whose efforts have led to excellent medical care, advanced technologies, and new drugs for treating AIDS and AIDS-related diseases. The University remains committed to continuing support of all areas of AIDS research, emphasizing drug and vaccine development, pediatric AIDS, and AIDS prevention studies in groups at high risk for HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Quantitative evaluation of peer review of program project and center applications in allergy and immunology.

We compared the review patterns of applications for program projects and centers in allergy and immunology, reviewed by the National Institute of Allergy and Infectious Diseases review committee, with those of individual research projects in immunology, reviewed by three Division of Research Grants study sections. A high concordance between these review groups was obtained with respect to the application approval rate, mean score, and distribution of applications in various priority score ranges. Furthermore, we observed a high degree of consensus among reviewers on the quality of many program project and center applications, especially those with priority scores between 100 and 200.

Allergy and Immunology↗
PubMed1984

In vitro susceptibility of Escherichia coli of swine origin to carbadox and other antimicrobials.

Swine fecal Escherichia coli isolates were tested with the Microtiter broth dilution method for susceptibility to carbadox and 11 other antimicrobials. Of the 138 strains, 136 were resistant to sulfadiazine, 120 to tetracycline, 95 to streptomycin, and 63 to carbadox. Resistance to the remaining antimicrobials also was noted in various degrees, with the exception of amikacin, to which all strains were susceptible. Carbadox-resistant strains also were resistant to other antimicrobials. The multiple resistance pattern was most common to sulfadiazine and tetracycline or a combination of sulfadiazine, tetracycline, and streptomycin.

Animals↗
PubMed1982

Histone patterns during early embryogenesis in the euchiuroid Urechis caupo.

Histones were isolated from nuclei of Urechis caupo unfertilized eggs and embryos from early cleavage through gastrula. Polyacrylamide gel electrophoresis showed the presence of a slow migrating H1s fraction in the egg which was replaced by a faster migrating H1 during development. Radioactive labelling showed no synthesis of H1s from fertilization up to gastrula and a high rate of synthesis of H1 relative to the other histones during cleavage and blastula stages.

Female↗
PubMed1978

National Institute on Aging cell-line repository.

The National Institute on Aging (NIA) has established, under contract, a cell-line repository. This resource is designed to support NIA grantees, prospective grantees, and other laboratories engaged in cellular aging research. Services of the NIA Cell-Line Repository include storage and distribution of characterized, contaminant-free normal diploid and genetically-marked human cell-lines.

Adult↗