Biomedical subjects
Publications and source records attributed to N K Kormilitsyna.
The lesion of paraventricular hypothalamic nucleus (PVN) led to the hypofunction of the thyroid gland. After the PVN lesion, no activation of the thyroid gland occurred during cold adaptation. The delay in the cold adaptation seems to be due to the inhibition of the thyroid function after the PVN lesion.
The lesion of paraventricular hypothalamic nuclei (PVN) led to a delay in the development of cold adaptation in white rats, the latter starting with no activation of pituitary-adrenocortical system. After the PVN lesion, corticosteroid response to immobilization was inhibited. The delay in formation of the cold adaptation seems to be due to the changes in the pituitary-adrenocortical system response to the stress after the PVN lesion.
The role of paraventricular hypothalamic nuclei (PVN) in the development of cold adaptation was studied in chronic experiments on white rats. Animals with the PVN lesions revealed a low resistance against cooling, a small increase of brown adipose tissue mass and no calorigenic effect of noradrenaline after long-lasting cold exposure. The data obtained suggest that the PVN lesions delayed the development of specific mechanisms of adaptation to low temperature.