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Biomedical subjects

N K Lohika

Publications and source records attributed to N K Lohika.

2 recordsLinked to original sources
PubMed1979

Antifertility activity of alpha-chlorohydrin (3-chloro-1, 2 propanediol, U-5897) on the female rats.

alpha-chlorohydrin administration brings about regression in the corpus luteum and shedding of the uterine endometrium, indicating its luteolytic activity, alpha-chlorohydrin inhibited vaginal keratinization and interrupted the sex cycle. A dioestrous leucocytic pattern of the vaginal smear is retained during medication. Decreased synthesis of RNA, protein, sialic acid and glycogen concentration in the uterus and vagina suggest possible antioestrogenic action of the compound. The antifertility action of the drug may be due to its antioestrogenic property.

Adrenal Glands↗
PubMed1979

Effect of cyproterone acetate on the genital organs of female rats.

Effects of cyproterone acetate, a synthetic steroidal compound, on the reproductive organs of female rats have been investigated. This agent causes reduction in ovarian weights indicative of suppression of pituitary gonadotrophins. Oestrogenic nature of cyproterone acetate was investigated in intact and ovariectomized animals taking uterine weight, vaginal keratinization and other oestrogen sensitive biochemical parameters. Cyproterone acetate in ovariectomized animals induced vaginal keratinization, increase in uterine weight and uterine protein, RNA, glycogen and sialic acid contents. These effects were parallel to the effect of oestradiol dipropionate in ovariectomized animals, thus indicating oestrogenic activity cyproterone acetate. The histological and biochemical parameters lead to the conclusion that cyproterone acetate possessed antifertility property due to its inherent oestrogenic nature.

Adrenal Glands↗