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Biomedical subjects

N K Malinovskaia

Publications and source records attributed to N K Malinovskaia.

At least 19 recordsLinked to original sources
PubMed2006

[Geomagnetic pulsations and myocardial infarctions].

AIM: To clarify the role of geomagnetic micropulsations Pc1 (0.2-5s) in the range of the basic heart rate in an increase in the number of myocardial infarctions (MI) and sudden death (SD). MATERIAL AND METHODS: MI incidence rate in Moscow for 1979-1981, SD incidence rate in Bolgaria for 15 years for rural and urban population and data on micropulsations Pc1 were analysed. RESULTS: The number of MI rose both in Moscow and Bulgaria when the above micropulsations occurred during geomagnetic disturbances. Season variations of MI and SD incidence are related with a season trend in Pc1 duration with maximum in winter when even moderate magnetic disturbances are biotropic, while in summer even intensive magnetic disturbances do not cause extra number of MI. CONCLUSION: Factor intensifying influence of geomagnetic disturbances with Pc1 in winter may be low production of melatonin caused by light insufficiency.

Bulgaria↗
PubMed2003

[Ultrastructural changes in cells of the antral gastric mucosa in patients with duodenal ulcers treated with melatonin].

AIM: To study ultrastructural condition of the cels in antral gastric mucosa in patients with duodenal ulcer on melatonin treatment. MATERIAL AND METHODS: Electron microscopy was made of biopsy specimens of antral stomach mucosa obtained from 14 patients with duodenal ulcer (DU) in exacerbation and in clinicoendoscopic remission after therapy with proton pump blockers (group 1) and after this therapy combined mth melatonin (group 2). RESULTS: In patients of group 2 there was an increased number of differentiated cover and principal cells, moderately differentiated parietal cells predominated. CONCLUSION: Melatonin is one of the drugs potentiating trophic processes in gastric mucosa.

Adult↗
PubMed2003

[Melatonin: ulcer disease and seasons of the year].

Melatonin produces a great variety of effects in human organism and plays an essential role in normal function of the body. This explains growing interest of medical researchers to this substance. The paper provides the results of 3-year studies of seasonal rhythm of melatonin production in patients with duodenal ulcer. Acute disorders of circadian and seasonal melatonin production in summer and autumn were discovered in patients with duodenal ulcer. These findings suggest involvement of abnormal melatonin production in pathological mechanisms of autumn exacerbations of duodenal ulcer.

Adult↗
PubMed2001

[Melatonin production in hypertonic patients during magnetic storms].

AIM: To study mechanisms of action of natural magnetic field of the Earth on arterial pressure (AP) and melatonin production in patients with essential hypertension (EH) stage II. MATERIAL AND METHODS: Clinical, laboratory and device investigations covered 52 men with EH stage II (mean age 42 +/- 0.92 years) and 11 healthy men (mean age 23 +/- 1.46 years). Mean 24-hour, mean daytime, mean night systolic and diastolic pressures, 24-h index, time hypertensive index, standard deviation were registered. Melatonin was measured in the urine by radioimmunoassay. Geomagnetic situation was assessed by K-index (quiet--under 15, disturbed--15-25, magnetic storm--above 25). RESULTS: In hypertensive patients AP grew with growth of geomagnetic activity. In normal subjects AP remained normal. The 24-h rhythm of AP variability in hypertensives was normal. Magnetic storm affected melatonin production in EH patients noticeably: night and daytime production of melatonin was low. In normal subjects night melatonin production was high. CONCLUSION: AH stage II patients respond to magnetic storm with maladaptation, i.e. a rise in AP and low melatonin production.

Adult↗
PubMed2000

[Melatonin production in hypertensive patients].

Hypertensive subjects were examined for production of melatonin. In severe hypertension night levels of melatonin diminished, the day production is as in the controls. The role of melatonin in pathogenesis of essential hypertension is discussed.

Adult↗
PubMed2000

[Ulcer protective effect of melatonin during artificial simulation of desynchronization in rats].

The study was made on Wistar rats. A shift in endogenous biological rhythms was simulated by that in the light phase by 12 hours and evaluated by the shift in the rhythm of rectal temperature. Experiments revealed that desynchronization potentiated ulcerative processes in the rat stomach. The study demonstrated the protective effect of intraperitoneally injected melatonin to prevent the formation of ulcerative defects in the rat stomach during artificially simulated desynchronization.

Animals↗
PubMed1997

[Effects of disturbances of natural magnetic field of the Earth on melatonin production in patients with coronary heart disease].

The obtained results clearly evidence for the influence of magnetic disturbances and storms on melatonin production in patients with ischemic heart disease. Improvement of 24-hour rhythm of melatonin secretion during the period of magnetic disturbances says in favour of this influence while an overall fall of melatonin production during magnetic disturbances and storms is an apparent negative factor.

Aged↗
PubMed1997

[Emotional stress and blood melatonin levels].

Blood serum melatonin concentrations were measured in male Wistar rats exposed to acute water-immersion emotional stress (ES) during intraperitoneal injections of physiological saline or different doses of melatonin. ES increased blood melatonin levels in rats receiving physiological saline 1 hour before or just after ES. When physiological saline was administered just ES, blood melatonin concentrations remained unchanged. The blood levels of melatonin both in control and stressed animals injected with exogenous melatonin were higher than those in rats given physiological saline alone. Immersion ES decreased blood melatonin concentrations in rats receiving different exogenous melatonin doses just before ES. However, in rats given melatonin, 1.0 mg/kg, after ES, its blood levels after ES was higher than those in the animals unexposed to stress. The findings suggest that it is just exogenous rather than endogenous melatonin that is consumed in rats injected with its different doses just prior to immersion ES.

Animals↗