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Biomedical subjects

N K Mathur

Publications and source records attributed to N K Mathur.

At least 37 records · Page 2Linked to original sources
PubMed1987

Increased macrophage activity in protein A treated tumor regressed animals.

Male swiss albino mice transplanted with 1 x 10(6) viable fibrosarcoma tumor cells were treated with Protein A (60 micrograms/kg) right from the day of transplantation for 4 weeks, twice weekly. The therapy resulted in lesser tumor incidence, significant inhibition of tumor growth and enhanced percent survival in treated animals as compared to untreated controls. Treated animals also showed gains in body weight, an increase in peripheral blood leucocyte count, significant increase in macrophage function and number. Stimulation of macrophage number and macrophage function by Protein A may be related to its antitumor.

Animals↗
PubMed1985

Contact dermatitis in tie and dye industry workers.

A survey of the 'Tie and Dye' industry of Jodhpur City in India was made to investigate occupational dermatoses. 49 (16.6%) of 250 workers had incapacitating dermatitis. Skin lesions were seen mostly over the dorsa of the hands and fingers. 26 patients were patch tested with various dyes and chemicals; 14 were positive. Fast Red RC salt was the most potent sensitizer. Other dyes showing positive reactions were Orange GC salt, Bordeaux GP salt, Blue B salt, Red B base and naphthol.

Adult↗
PubMed1984

Serum zinc levels in subtypes of leprosy.

Serum zinc levels were estimated in 146 patients with different types of leprosy and 40 control subjects. Tuberculoid patients were found to have normal serum zinc levels. A gradual reduction in serum zinc levels was observed from TT to LL. Serum zinc levels were not significantly higher in patients treated with dapsone for approximately 18 months. The cause of hypozincemia is not clear, but the findings suggest that there are correlations among bacillary load, immune status, and serum zinc. Zinc deficiency could be one of the factors involved in the nonspecific suppression of cell-mediated immunity in lepromatous leprosy.

Adolescent↗
PubMed1984

Oral zinc as an adjunct to dapsone in lepromatous leprosy.

Oral zinc was tried in 15 cases of multibacillary leprosy as an immunostimulant in addition to conventional antileprosy drugs. Results were compared with those in ten similar cases treated with dapsone alone. Cases treated with zinc showed faster clinical improvement, regrowth of eyebrows, rapid fall in the bacterial index (BI) and in the bacterial index in the granuloma (BIG), early and greater influx in lymphocytes in the granuloma, and neovascularization. Upgrading occurred in 6 out of 15 patients taking zinc, but in only 1 out of 10 patients in the control group. Five out of six patients who showed upgrading in the treated group became lepromin positive. Only one patient (BL) showed lepromin conversion in the control group.

Adult↗
PubMed1983

Oral zinc in recurrent Erythema Nodosum Leprosum reaction.

Oral zinc sulfate was tried in Eight cases of recurrent Erythema Nodosum Leprosum. To control ENL, they required high dosage of clofazimine and steroids for prolonged periods. After instituting oral zinc, the dose of clofazimine could be reduced to 100 mg twice a week and steroids could be withdrawn completely. Four out of five patients who were not tolerating dapsone earlier, started tolerating dapsone. Incidence and severity of subsequent ENL was also reduced.

Administration, Oral↗
PubMed1983

Langerhans cell and leprosy.

Langerhans cell population was counted in 44 patients of different types of leprosy and compared with 12 normal volunteers. Significant reduction in LC count was observed in cases of LL (253.44 +/- 136.83/mm2) and BL (349.36 +/- 121.67/mm2). Whereas in TT (854.60 +/- 332.01/mm2) and BT (715.76 +/- 235.33/mm2) there was no significant difference, as compared to Normal (927.43 +/- 103.87/mm2). Treatment had no influence on LC population in both the polar types of leprosy. Role of these immunocompetent dendritic cells in the pathogenesis of leprosy is discussed.

Adolescent↗
PubMed1981

Leprosy in Jaipur (Rajasthan) - a clinical and epidemiological study.

An analysis of 537 patients of leprosy registered in Leprosy Clinic attached to the S.M.S. Medical College and Hospital Jaipur from March 1977 to May 1980 has been made. An incidence of 4.1 per 1000 patients attending Skin Out Patient Department was found. Lepromatous leprosy (30%) was the most common form. Three hundred and thirty five (62.3%) cases were in the age group of 30-59 years. Males were affected twice as compared to females. 5.0 percent of affected families showed multiple cases.

Adolescent↗
PubMed1978

Leprosy in Jodhpur (Rajasthan). Clinical and epidemiological study.

A clinical and epidemiological study of leprosy revealed 232 cases in Jodhpur (Rajasthan); a non-endemic area. Males were three times more affected than females. Lepromatous leprosy was the most common type (70.70%). Maximum number of cases were observed in the age group 20-49 years. The probable causes for an increase in incidence are discussed.

Adolescent↗