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Biomedical subjects

N K Soni

Publications and source records attributed to N K Soni.

At least 19 recordsLinked to original sources
PubMed2005

Evaluation of a breast cancer nomogram for prediction of non-sentinel lymph node positivity.

AIMS: This study evaluates the breast cancer nomogram (BCN), an online tool developed by Memorial Sloan-Kettering Cancer Center to determine the rate of non-SLN positivity, in an independent cohort of SLN positive patients. MATERIAL AND METHODS: Available data between 02/2000 and 06/2004 in two prospective databases, 749 cases had successful SLN biopsy including 149 axillary-SLN metastases study cases. These cases had accurately graded tumours up to 9 cm in size and CAD with a minimum total 10 nodes removed. Histopathological assessment of nodes included hematoxylin and eosin staining and/or immunohistochemistry. Computerized BCN was used to estimate probability of non-SLN positivity and compared with actual probability after grouping into deciles. RESULTS: The trend of actual probability in various decile groups was comparable to the predicted probability. An area under the receiver operating characteristic curve was 0.75 as compared to 0.76 in the original study. CONCLUSION: Although this study is small, the results are encouraging and suggest the nomogram is a useful tool to estimate the likelihood of positive axillary non-SLN. However, variations in pathological assessment between centres are the major impediment to widespread application of BCN. If SLN positive patients decline the standard recommendation of CAD or entry into clinical trials evaluating the significance of CAD then the BCN could help in decision making.

Adult↗
PubMed2004

Theoretical prediction of surface tension of ternary liquid system (nitrogen + oxygen + argon) at elevated temperature and different pressure.

The surface tension of a ternary liquid mixture of nitrogen, oxygen, and argon has been calculated by a new approach using critical constants Pc, Vc, and Tc at temperatures ranging from 90 to 110 K and pressure up to 865 kPa. New formalism has been made by modifying the Brock-Bird relation. The computed values are compared with the experimental findings. Satisfactory results have been obtained.

Journal Article↗
PubMed2000

Endoscopy in nasal myiasis.

Nasal myiasis is a common disease in tropical and developing countries. The maggots cause extensive necrosis, sloughing and destruction of intranasal tissue and reach to deep and inaccessible areas of the nose and paranasal sinuses. In such a situation removal of maggots is difficult by manual extraction and several sittings are required. To overcome this problem nasal endoscope is being used for removal of maggots under direct vision. In comparing both methods nasal endoscopic procedure is found to be superior to the manual extraction method for removal of maggots. The maggots located in deep and inaccessible area can be approached more easily by endoscopic procedure. The disease is being controlled in shorter time and in few sittings. Thus quick and complete eradication of myiasis is possible before the maggots cause irreparable damage to the intranasal tissues.

Adult↗
PubMed1997

Microscopic rhinoscopy in lepromatous leprosy.

Ten patients with lepromatous leprosy have been studied to detect intranasal pathology by conventional naked eye rhinoscopy and also by use of the surgical microscope. The comparison of both methods reveals that microscopic rhinoscopy is superior in providing more accurate details of intranasal lesions in leprosy and biopsy can be taken in a precise manner from accurate and representative sites. Use of the microscope with adequate exposure and bright illumination provides precise details of lesions and an opportunity for bimanual manipulation, photography, teaching and recording. Thus, it is worthwhile to perform microscopic rhinoscopy in such cases.

Adult↗
PubMed1997

Scleroma of the larynx.

Twenty-two cases of rhinoscleroma were studied to determine the involvement of the larynx. The study revealed that scleroma affected the larynx in 40 per cent of cases. In the larynx, scleromatous lesions were found in the subglottic region and the disease was observed in stages i.e., atrophic, granulomatous (proliferative i.e., nodular) and a fibrotic or sclerotic (scarring) stage as found in the nose. The role of laryngological examination is established in the diagnosis of asymptomatic and early laryngeal lesions and in assessing response to initial treatment. Extensive granulomatous lesions were treated by open excision by the laryngofissure approach which was found to be the best method resulting in a quick recovery without any evidence of subglottic stenosis. The disease as a whole is discussed in the light of available literature.

Adolescent↗
PubMed1997

Intranasal anaesthesia in lepromatous leprosy.

Intranasal sensation was assessed in a group of 25 lepromatous leprosy patients. It was found that 17 patients showed partial or complete impairment of intranasal common sensation. The intranasal anaesthesia is found to be related to the advancement of intranasal disease. Loss of sensation may lead to repeated trauma, ulceration and epistaxis, due to repeated 'picking' of the nose in an attempt to remove the crustings. It is suggested therefore, that the lepromatous leprosy patient should be taught to take care of the nose just as they are instructed in the care of their hands and feet.

Adult↗
PubMed1995

Leprosy of the eustachian tube (nasopharyngoscopic study).

The technique of nasopharynogoscopy affords an accurate assessment of the lesions at the orifices of the eustachian tube. It was performed in 30 patients suffering from lepromatous leprosy in order to determine the type, nature and site of the lesion. Involvement of the eustachian tube in leprosy may begin with a localized area of erythema progressing to granuloma formation or ulceration. Leprous lesion at the eustachian tube orifices was related with subsequent changes in the tympanogram pattern. Nasopharyngoscopy is also found to be of therapeutic value in removing the crust, discharge and granulations at the eustachian tube orifices.

Adolescent↗
PubMed1994

Scleroma of the lower respiratory tract: a bronchoscopic study.

Twenty cases suffering from rhinoscleroma were studied. Bronchoscopy was performed for detection of secondary involvement of the subglottic region, trachea and bronchus. The study revealed that the larynx was involved in 40 per cent, the trachea in 20 per cent and the bronchus in 10 per cent of cases. The intranasal lesion, endotracheal and endobroncheal lesions all occur in the form of an atrophic stage, granulomatous (proliferative) stage and finally a fibrotic or scarring stage. The role of bronchoscopy in early diagnosis, initial symptomatic treatment and in follow-up is discussed in the light of the available literature.

Adult↗
PubMed1994

Scleroma of the eustachian tube: salpingoscleroma.

Rhinoscleroma is a chronic specific granulomatous inflammatory condition that has an affinity with the mucosa of the upper respiratory tract. Involvement of the eustachian tube is uncommon. In the present study nasopharyngoscopy was performed in 20 patients with rhinoscleroma to find out the type, nature and site of the lesion at the orifices of the eustachian tube. A lesion involving the eustachian tube was found in six cases (30 per cent). Lesions occurred in the form of atrophic changes with crusting, granuloma and fibrotic thick areas. Involvement of the eustachian tube was found to be associated with intranasal scleroma and was more common at the granulomatous stage. Eustachian tube scleroma had a possible association with subsequent changes in the tympanogram pattern. Nasopharyngoscopy was found to be of therapeutic value in removing the crust, discharge and granulations at the eustachian tube orifices.

Adolescent↗
PubMed1992

Leprosy of the larynx.

The result of a study conducted on 30 patients of lepromatous leprosy regarding laryngeal involvement is presented. The incidence of leprous laryngitis is 36.6 per cent in this part of India in lepromatous leprosy patients. Leprosy is long standing disease so laryngeal lesions developed gradually and may be asymptomatic in some cases while others have been found to have variety of clinical manifestation in form of congestion, infiltration, nodulation, thickening and fibrosis. Anti-leprosy chemotherapy is equally effective on these lesions. A screening survey of laryngeal pathology in such cases should be done periodically.

Adolescent↗
PubMed1992

Antroscopy in rhinoscleroma.

Rhinoscleroma is a chronic specific granulomatous inflammatory condition that has an affinity to the mucosa of the upper respiratory tract. Involvement of maxillary antrum is said to be very uncommon. In the present study antroscopy was performed in 20 patients with rhinoscleroma to find out the type, nature and site of the lesion in the maxillary antrum. The maxillary antrum was involved in 60 per cent of cases with rhinoscleroma. The lesions occurred in the form of atrophic changes, granuloma, and the fibrotic thick healed stage. The anterior-inferior part and medial wall of the antrum are found to be more commonly affected. It is suggested that involvement of maxillary antrum in scleroma may act as a reservoir of infection and such patients may therefore take a longer time to respond to antibiotic therapy.

Adult↗
PubMed1992

Verocytopathic activity of Escherichia coli O157 & other 'O' serogroups isolated from patients of diarrhoea.

Twenty diarrhoeal isolates identified as Esch. coli O157 were screened for cytopathic activity on the continuous Vero cell line. Of these, seven strains (35%) showed cytopathic effect which was maximum on the 4th day after inoculation, with a maximum titre of 1 in 128. The total loss of cytopathic activity was observed in the positive filtrates subjected to a temperature of 100 degrees C for 15 min, while heating at 65 degrees C for 15 min, resulted in partial loss of this activity. All the verocytopathic strains were obtained from infants and children and were devoid of heat labile (LT) and heat stable (ST) toxins as well as enteroinvasive property.

Adolescent↗
PubMed1989

Antroscopic study of the maxillary antrum in lepromatous leprosy.

The technique of antroscopy affords an accurate assessment of chronic sinus disease. It was performed in twelve patients suffering from lepromatous leprosy in order to determine the type, nature and site of the lesion. Antral involvement with lepromatous leprosy may begin with a localized area of erythema progressing to granuloma formation or ulceration. The antero-inferior part of the antrum is the most commonly affected site.

Adult↗
PubMed1988

Radiological study of the paranasal sinuses in lepromatous leprosy.

Thirty patients of lepromatous leprosy have been studied by radiological investigation for affection of paranasal sinuses. It has been found that leprosy involves all groups of sinuses and maxillary antrum is found to be more commonly affected. Diffuse hypertrophy type of lesion is more commonly recorded in maxillary antrum, in x-ray of paranasal sinuses. The clinical significance and importance of extension of disease in the sinuses is discussed in the light of available literature.

Ethmoid Sinus↗
PubMed1988

Gustatory rhinorrhoea syndrome: result of misreinnervation in leprosy.

A case of excessive rhinorrhoea in response to taste stimulus, due to misdirection of regenerating nerve fibres following recovery of facial nerve in leprosy is described under title of "Gustatory Rhinorrhoea Syndrome". The pathophysiology of such conditions are discussed in the light of available literature.

Adult↗
PubMed1988

Epistaxis and leprosy.

Forty-four leprosy patients with epistaxis were analysed. Aetiopathogenesis of epistaxis in leprosy is discussed in the light of available literature. It has been suggested that epistaxis is more frequent and severe in leprosy patients and more liable to have complications. Epistaxis in leprosy with nasal lesions may alarm the physician that patient has some systemic disorder.

Epistaxis↗