[The effect of the blood pressure lowering effect of bopindolol (Sandonorm) in patients with mild and moderate hypertension].
The effect of a once a day dose one or one and a half mg bopindolol on mild to moderate hypertensive patients was studied. During the treatment the changes in blood pressure, heart rate, serum triglyceride, cholesterin, HDL cholesterin were examined. The drug was given as monotherapy to 9 previously untreated patients with a mean blood pressure of 163/102 mm Hg. 12 patients, who had received a combination therapy including beta-blocking agents, were treated with bopindolol instead of the previously taken beta-blockers. The initial mean blood pressure of this group was 140/80 mm Hg. The patients' age was between 35 and 72. The observation period was 12 months. The cardiac performance was examined by bicycle ergometry. On the base of the results the authors think that bopindolol is effective in blood pressure lowering both in mono- and combination therapy, and it doesn't increase the level of blood lipids. No side-effects were observed. The results of the bicycle ergometry indicated better cardiac performance. Because of its long duration of action it is important to emphasize that bopindolol in a once a day dose of one or one and a half mg is effective in the treatment of mild to moderate hypertensive patients.