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Biomedical subjects

N Kamil

Publications and source records attributed to N Kamil.

4 recordsLinked to original sources

Fracture of the penis.

Fracture of the penis is not an uncommon urological emergency. Six patients with this injury, treated at the Institute of Urology, General Hospital, Kuala Lumpur, since 1988, were reviewed. Their ages ranged from 21 to 30 years old (mean 25). Four cases were self-inflicted by abnormal bending and 2 cases occurred during sexual intercourse. A sudden "cracking sound", violent pain, rapid flaccidity and deformity of the penis were documented. Duration of injury at presentation ranged from 12 to 90 hours (mean 35 hours). Primary repair of the tunica albuginea with absorbable suture was performed in all cases. The results of surgery was excellent, with restoration of normal function in 4 patients (2 patients defaulted follow-up). We advocate immediate surgical repair for this injury.

Adult↗

Kinetics of bromadiolone, anticoagulant rodenticide, in the Norway rat (Rattus norvegicus).

Rats (Rattus norvegicus) dosed orally with the rodenticide bromadiolone (0.8 and 3 mg/kg) were sacrificed in groups of 4 rats at various times up to 97 hours after administration. Bromadiolone was assayed in plasma, liver and kidney by an HPLC method. The compound disappeared slowly from the organism with a half-life of 25.7 hours for the 0.8 mg/kg dose and 57.5 hours for the 3 mg/kg. Concentrations in liver were rapidly established and were 14- to 46-fold higher than plasma concentrations. 97 hours after 3 mg/kg dose, liver concentrations were about 1.5 micrograms/g. Bromadiolone levels in kidney were slightly higher than those observed in plasma, with a longer half-life.

4-Hydroxycoumarins↗