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N Kanai

Publications and source records attributed to N Kanai.

At least 91 records · Page 5Linked to original sources
PubMed1987

Exfoliative cytopathology of alveolar rhabdomyosarcoma.

Exfoliative cytopathology of alveolar rhabdomyosarcoma is presented. A 34-year-old male was found to have alveolar rhabdomyosarcoma of the retroperitoneum at autopsy. Ascites was recognized in the course of this disease. Cytological features in the ascites were characterized by relatively small-sized ovoid cells observed singly or in loose clusters. The neoplastic cells possessed small amount of rather vesicular cytoplasm and an eccentric nucleus. The nucleus characteristically revealed multiple deep indentations in the nuclear membrane, a few prominent eosinophilic nucleoli and finely granular or evenly distributed chromatin pattern. These cytological findings, especially the nuclear features, might be useful to differentiate alveolar rhabdomyosarcoma from other neoplasms which consist of relatively small-sized ovoid cells even if the striated muscle origin cannot be confirmed by immunoperoxidase staining.

Adult↗
PubMed1987

Clear cell carcinoma of the pancreas.

A rare autopsy case of clear cell carcinoma of the pancreas developing in a 71-year-old Japanese male is described. He complained of epigastralgia and back pain and was clinically diagnosed as having primary pancreatic cancer. After death due to disseminated metastasis and cachexy, autopsy revealed pancreatic clear cell carcinoma metastasizing to various organs including the lungs (lymphoangiosis carcinomatosa). The tumor was almost entirely composed of clear cells with cytoplasm weakly positive for PAS and alcian blue, and negative for Sudan III stains. Histological differential diagnosis from the clear cell carcinoma of other organs, especially that of kidney, is also mentioned.

Adenocarcinoma↗
PubMed1987

[An autopsy case of mucin-producing pancreatic cancer].

A 85-year-old woman with a mucin-producing pancreatic cancer is reported. The patient, who had been diabetic for 2 years, was admitted in March of 1984 to our hospital because of a fever and cough. On admission, a hard tumor was found on the right hypochondric region. Ultrasonogram and computed tomography revealed a cystic pancreas head tumor containing mucin and a dilated pancreatic duct. During an ERCP examination, Vater's papilla was found to be enlarged and a biopsy showed papillary adenocarcinoma. Also, the levels of CEA and CA 19-9 were elevated 11.3 ng/ml and 1300 U/ml, respectively. On Feb. 13, 1985, she died due to panperitonitis that resulted from a perforated duodenal ulcer. Microscopic examination of the pancreas showed a papillary adenocarcinoma producing mucin, a dilated pancreatic duct and atrophy of the islets. No metastatic lesion was found. The pathogenesis and the clinical characteristics of the mucin-producing pancreatic cancer are discussed.

Adenocarcinoma, Mucinous↗
PubMed1986

Exfoliative cytopathology of atypical pulmonary carcinoid: a case report.

A 35-year-old man was diagnosed as having lung cancer and died six years later. In spite of an initial histological diagnosis of squamous cell carcinoma from the biopsy material, the correct diagnosis of atypical carcinoid was made by sputum cytology. The carcinoid cells had exfoliated into the sputum collected immediately after bronchofiberscopic examination although the bronchial tissues obtained at this time did not reveal any histological findings suggestive of neoplasia. The distinctive cytological features in sputum of atypical carcinoid that differentiate it from small cell carcinoma are considered to be the relatively abundant vesicular cytoplasm and the finely reticular or granular chromatin pattern observed in well-preserved tumor cells. The present case also suggests that clinical data may be indispensable to the differential cytological diagnosis of such tumors.

Adult↗
PubMed1984

Effect of metoclopramide in plasma vasopressin in man.

The effect of metoclopramide, a dopamine blocker, on arginine vasopressin (AVP) secretion was investigated in normal males. After a bolus injection of metoclopramide (10 mg), all subjects (n = 7) demonstrated an increase of 80.3% (from 0.71 +/- 0.12 (Mean +/- S.E.) to 1.28 +/- 0.24 pg/ml, P less than 0.005) in plasma AVP at 15 min. In controls (n = 7) plasma AVP levels did not change after saline injection (2 ml). Because plasma osmolality and blood pressure did not change, the elevation of plasma AVP levels induced by treatment with metoclopramide may be due to its central effect as a dopamine inhibitor. Although plasma AVP levels increased again at 90 and 120 min after a bolus injection of metoclopramide, accompanying falls in blood pressure (4-5%) make the interpretation concerning the contribution of dopamine to AVP secretion in a late phase uncertain. In summary, plasma AVP levels were shown to be significantly increased by a metoclopramide bolus, suggesting that AVP secretion is under tonic inhibition by dopamine.

Adult↗
PubMed1979

Type C particles in culture of human glioblastoma cells.

A long-term cell culture of human glioblastoma was investigated microscopically, virologically, and biochemically. Reverse transcriptase activity was detected in cultured human glioblastoma cells. 3H uridine was incorporated into particles of buoyant density at 1.07 g/ml (Ficoll) which is equal to that of Oncorna virus particles, but 3H thymidine was not incorporated at all. Furthermore, reverse transcriptase activity was also demonstrated with the particles, suggesting that the cultured human glioblastoma cells were producing type C Oncorna virus. Ultrastructural observations of cell culture of glioblastoma showed type C virus particles in cisternae and culture medium. Budding of the virus was also seen on the surface of the cell. The mean diameter of the particles was approximately 100 nm. Ca. 1.1 nm of spikes protruded from the envelope. Both types of virions were observed, i.e. the doughnut-shaped type form and the solid circular form.

Adolescent↗
PubMed1976

[Delayed radiation necrosis of the brain simulating a brain tumor--report of two cases (author's transl)].

Two cases of delayed radiation necrosis of the brain were reported. Case 1 was a 50-year-old man who had right hemiparesis and disorientation 26 months after Linac irradiation (5,000 rad), preceded by the operation for right maxillar carcinoma. A left carotid angiogram demonstrated a left temporal mass lesion, extending the frontal lobe. Case 2 was a 41-year-old man who had previously the operation for right intraorbital plasmocytoma, followed by two times Co irradiation (6,400 rad, and 5,000 rad). He had the signs and symptoms of intracranial hypertension 36 months after last irradiation. A left carotid angiogram demonstrated a left temporal mass lesion. Both cases were treated by administration of steroid hormone, which alleviated the signs and symptoms, followed by the temporal lobectomy. Microscopic examinations showed necrosis of the brain tissues associated with hyaline degeneration of blood vessel walls and perivascular cell infiltration. The signs and symptoms of intracranial hypertension subsided postoperatively. The other thirteen cases as same as ours were collected from literature, which showed the signs and symptoms simulating a brain tumor (like a metastic brain tumor) after the irradiation to extracranial malignant tumors, and the diagnosis of radiation necrosis were made by the operation or autopsy. A follow-up for a long time is necessary, because the pathological changes in the brain may be progressive and extending in some cases, although the decompressive operations for mass lesion are excellent in result.

Adult↗
PubMed1976

[Adenoid cystic carcinoma extended to Gasserian ganglion-report of two cases (author's transl)].

Adenoid cystic carcinoma is an uncommon tumor, especially in cases of its extension into the cranial cavity. Two cases of this tumor involving Gasserian ganglion were reported. The first case was a 47 year old female who developed paresis of the right side fifth cranial nerve. The plain skull X-ray of the axial view demonstrated enlargement of the right sided foramen ovale. The tumor was removed exploring the middle fossa extradurally, however its extention through the foramen ovale remained behind. A small induration was found at the base of the oral cavity postoperatively, and the biopsy revealed characteristic findings of adenoid cystic carcinoma histologically. Radiation therapy was followed by considerable clinical improvement.

Adult↗
PubMed1976

Neuroepithelial Cyst of the cerebellar vermis.

A cyst located in the cerebellar vermis and causing obstructive hydrocephalus is described. The wall of the cyst was lined with ciliated and non-ciliated cuboidal epithelial cells which were completely invested by a basement membrane.

Adult↗