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Biomedical subjects

N Kh Abdullaev

Publications and source records attributed to N Kh Abdullaev.

At least 19 recordsLinked to original sources
PubMed1976

[Interrelationship between the structure, microcirculation and tissue-vascular permeability of the liver after experimental toxic damage].

Biomicroscopic and morphological studies demonstrated that in experimental heliotrine affection of the liver there occurred very early and marked microcirculatory disturbances which preceded the parenchymal damage. With the further progress of the pathomorphological changes and chronization of the pathological process in the liver one of the leading roles was played by the advance of microcirculatory disturbances and of the tissue-vascular permeability leading to hypoxia of the hepatic tissue and derangement of the metabolic processes in the organ.

Animals↗
PubMedDate not supplied

[Diabetogenic and atherogenic effects of glucose].

Tests were set up on 59 albino male-rats with reproduced functional overstress and depletion of the insular system of the pancreas thorough a long-term (for 50, 100 days) peroral introduction of glucose (2 g/100 g body weight, every other day) and with and alloxan-induced diabetes (achieved by poisoning the animals with a 2.5% alloxan solution, 15 mg/100 g administered in a single dose intraperitoneally). A comparison of the data obtained ascertained the presence of a number of similar pathobiochemical changes in the metabolism, viz. hyperglycemia, an increase of the free cholesterol fraction, a diminution of the bound cholesterol fraction and a fall of the insulin-like activity (ILA) in the blood serum, a rise in glycogen and beta-lipoproteids in the liver; morphologically--a reduced count of Langerhan's islands beta-cells, less intensive colouration of the specific granulation in their cytoplasma manifestations of vacuolar and granular dystrophy of the liver. Further tests were staged on 23 rabbits involving a long-term introduction of glucose (in amounts of 25 g/kg every other day) and a cholesterol-induced atherosclerosis (by administering 0.2 g/kg of cholesterol in oil, daily), which also showed similar changes in the figures of the carbohydrate and fat-lipoids metabolism, such as hyperglycemia, an increased level of total lipids, cholesterol and its fractions, beta-lipoproteids, a fall of ILA in the blood serum, as well as variations in the morphological picture of the aortic wall. The above findings suggest that a protracted administration of glucose can produce both diabetogenic and atherogenic effects.

Animals↗