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N Khan

Publications and source records attributed to N Khan.

8 recordsLinked to original sources
PubMed2016

Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism.

No adeno-associated virus (AAV) capsid has been described in the literature to exhibit a primary oligodendrocyte tropism when a constitutive promoter drives gene expression, which is a significant barrier for efficient in vivo oligodendrocyte gene transfer. The vast majority of AAV vectors, such as AAV1, 2, 5, 6, 8 or 9, exhibit a dominant neuronal tropism in the central nervous system. However, a novel AAV capsid (Olig001) generated using capsid shuffling and directed evolution was recovered after rat intravenous delivery and subsequent capsid clone rescue, which exhibited a >95% tropism for striatal oligodendrocytes after rat intracranial infusion where a constitutive promoter drove gene expression. Olig001 contains a chimeric mixture of AAV1, 2, 6, 8 and 9, but unlike these parental serotypes after intravenous administration Olig001 has very low affinity for peripheral organs, especially the liver. Furthermore, in mixed glial cell cultures, Olig001 exhibits a 9-fold greater binding when compared with AAV8. This novel oligodendrocyte-preferring AAV vector exhibits characteristics that are a marked departure from previously described AAV serotypes.

Animals↗
PubMed1978

[Early and late functional hearing results from a modified technique for tympanoplasty (author's transl)].

This paper is a comparative study of the early and late functional results of tympanoplastic operations, as modified by Khan. Following such surgery, we examined 494 patients who had been operated on between 1970--1972 in the ENT Clinic of the Free University of Berlin (Klinikum Westend). Preliminary and final hearing results were recorded with the aid of sound audiograms, which were critically assessed by two different types of evaluations. These included the results of pure-tone changes and speech reception thresholds as achieved by the tympanoplastic operations. On the basis of socially useful hearing improvements, the functional results of cases operated in our clinic are above average. The hearing gain shown from post-operative controls to the final studies is especially satisfactory, since this also includes an improvement in bone conduction.

Acoustic Impedance Tests↗
PubMed1978

Statistical analysis of muscle fibre types from four human skeletal muscles.

The joint distributions of the different muscle fibre types were investigated in human diaphragm temporalis, gastrocnemius and soleus muscles. (1) "Independence" was found between "white and intermediate" fibres in the diaphragm muscle; "red and intermediate" fibres in the temporalis muscle and "red and white" fibres in the soleus muscle. (2) An almost "linear relationship" was observed between red and intermediate fibres in both the diaphragm and soleus muscles and red and white fibres of temporalis muscle. (3a) In the diaphragm and soleus, the distribution of intermediate and red fibres exhibited large variation between different samples; unlike that shown by the white fibres. (3b) In the temporalis large variation was evident in the distribution of white and red fibres between samples; the intermediate fibre type showed minimal variation. (3c) No particular relationship was evident between different fibre types of the gastrocnemius muscle. The distribution of muscle fibres in all the 4 human muscles is "singular trivariate normal".

Adult↗
PubMed1976

Estimation of cardiac chamber size by routine chest radiography and echocardiography.

The size of the left atrium and both ventricles was estimated by routine chest radiography and compared to echocardiographic single-chamber measurements. Left atrial size correlated well, but echocardiography appeared to be considerably more sensitive in detecting enlargement. Estimates of left ventricular size by radiography and echocardiography showed considerable discrepancy, since the single-dimension echocardiographic technique does not reflect lateral or inferior enlargement, which is readily visible on the radiography; however, ultrasound can distinguish left ventricular hypertrophy from dilatation. Right ventricular size cannot be assessed accurately using the single-diameter technique. The authors suggest that a combination of both techniques would be more accurate than either modality alone and that two-dimensional cardiac studies should prove more reliable than the single-diameter method.

Cardiomegaly↗