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Biomedical subjects

N Khokhar

Publications and source records attributed to N Khokhar.

14 recordsLinked to original sources

Nephrotoxicity of nonsteroidal anti-inflammatory drugs.

Most nonsteroidal anti-inflammatory drugs can cause a variety of adverse renal effects when used in therapeutic doses. These effects range from elevation of BUN and creatinine to renal failure. Prostaglandin inhibition and T-lymphocyte disorder are believed to be the pathogenic factors. The effects are generally reversible with discontinuance of the drug, but some patients may require supportive management with hemodialysis and therapy with immunosuppressive agents.

Aged

Inappropriate secretion of antidiuretic hormone. An overview of the syndrome.

The syndrome of inappropriate secretion of antidiuretic hormone is characterized by production of less than maximally dilute urine in the presence of hypotonic plasma. It may be secondary to malignant disease, central nervous system disorders, or pulmonary disease, among other conditions, or it may be idiopathic. Manifestations are those of water intoxication, eg, confusion, fatigue, nausea, headache, and neurologic signs. The pathogenesis is not completely understood. Restriction of fluid intake to obtain a negative water balance is effective treatment.

Drug-Related Side Effects and Adverse Reactions