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N Khuri-Bulos

Publications and source records attributed to N Khuri-Bulos.

13 recordsLinked to original sources

Mass psychogenic illness following tetanus-diphtheria toxoid vaccination in Jordan.

In September 1998, more than 800 young people in Jordan believed they had suffered from the side-effects of tetanus-diphtheria toxoid vaccine administered at school; 122 of them were admitted to hospital. For the vast majority, their symptoms did not result from the vaccine but arose from mass psychogenic illness. The role played by the media, the children's parents, and the medical profession in the escalation of this mass reaction appeared, at first sight, to be unusual and even unique to the circumstances in Jordan at the time. A review of the literature showed, however, that this mass reaction was similar in many ways to previous outbreaks, even though the underlying causes varied. There are about 200 published accounts of mass responses to situations involving suspected poisoning or other events. Because such mass reactions are relatively rare and the triggers so diverse, individuals faced with responding to them are unlikely to have prior experience in how to handle them and are unlikely to take bold steps to prevent their escalation. Indeed they may be unaware that such events have been recorded before. The lessons learned from this incident in Jordan may help other immunization programme managers to handle crisis situations elsewhere.

Adolescent↗

Familial Mediterranean fever in children: the expanded clinical profile.

The clinical picture of familial Mediterranean fever (FMF) has been appreciably expanded in the last 10 years. Over 8 years, we studied the expanded clinical profile of FMF in 476 children. Of these, 81% had abdominal pain, 41% chest pain, 42% arthritis, 12% severe myalgia, 12% skin manifestations, 4% scrotal swelling, 3% recurrent episodic fever, and one child (0.2%) developed recurrent hyperbilirubinaemia. Two (0.4%) children developed renal complications which were reversed by colchicine; however of 19 probands, 36 family members suffered from chronic renal failure. Our study indicates a familial predisposition to nephropathy in certain families with FMF. This study is the first to report the expanded clinical profile of FMF in a large group of Arab children, giving an opportunity to compare the findings with those in children with FMF in other ethnic groups, and to help in the study of genotype-phenotype correlation.

Abdominal Pain↗

The changing epidemiology of diphtheria in Jordan.

Outbreaks of diphtheria used to occur regularly in Jordan, the last such outbreak being in 1977-78. Since that time, a massive immunization programme targeted at pre-school-age children has been markedly successful. Hence, when an outbreak of diphtheria occurred in 1982-83, it was unexpected. Of the 35 patients who were treated at the Jordan University Hospital, two died and the remaining 33 recovered uneventfully. Contrary to our findings in previous diphtheria epidemics in Jordan, this outbreak largely involved adolescents and young adults.

Adolescent↗

The paralytic poliomyelitis epidemic of 1978 in Jordan: epidemiological implications.

Poliomyelitis is endemic in Jordan, but until 1978 there were no epidemics. In that year, 66 children were admitted to the Jordan University Hospital with a paralytic illness, compared with 13 in 1979 and 11 in 1980. The epidemic reached a peak in the summer and fall of 1978. While 54% of the patients had not received any vaccine, 19% had received 3 doses of oral poliovaccine; 82% of the cases were in children less than 2 years of age, and all belonged to the lower socioeconomic group. There were 28 deaths with complications of the disease.Poliovirus was isolated from 10 out of 14 rectal swab samples examined (9 with poliovirus 1, 1 with poliovirus 2), and from 4 out of 13 throat specimens from the same patients. It is concluded that as a result of improving living standards in Jordan and neighbouring countries, more epidemics may occur unless immunization efforts against poliomyelitis are intensified.

Age Factors↗

Neonatal sepsis.

Explore the source record for details and available documents.

Female↗

Enteric fevers in children. The importance of age in the varying clinical picture.

The experience with enteric fevers in 71 children hospitalized at the Jordan University Hospital over a 4-year period is reviewed. Forty-one children were male and 30 female. Salmonella typhi was the causative organism in 26 and Salmonella paratyphi A and B, in the remaining 45 patients. Twenty-five children were less than two years of age, and the remaining 46, older than two. Gastroenteritis-like symptoms were seen more often in the younger age group, who also tended to lack splenomegaly and leukopenia. Further, the younger children were sicker at the time of admission and had a longer illness than the older ones. It is concluded that while enteric fevers lead to a mild illness in the older child, in infants and very young children the fevers were often characterized by a severe and protracted illness, the seriousness of which was complicated by delay in diagnosis.

Adolescent↗

Diphtheria in Jordan: a diminishing yet important paediatric disease.

Twenty-seven cases of diphtheria (15 male, 12 female) admitted over a 2-year period, 1977-1978, at the Jordan University Hospital were reviewed. The majority were admitted during autumn and were in the 2-9-year age group. Eleven patients were not vaccinated and six were questionably vaccinated; of these seven died. In 10 patients who were partially or completely vaccinated, only one died. Antitoxin was given to 23 patients at varying intervals after the onset of the disease. No antitoxin was given to the patients who were admitted after the tenth day of the illness. Fourteen complications developed in 13 patients. One patient died with upper airway obstruction, four died with myocarditis, and three patients died with the respiratory complications of polyneuritis. The case fatality rate was 29%. While in Jordan the incidence rate of diphtheria has been decreasing steadily, limited outbreaks are likely to continue to occur unless a higher immunization rate is achieved.

Adolescent↗

Neonatal Haemophilus influenzae infection. Report of eight cases and review of the literature.

Eight cases of neonatal Haemophilus influenzae infection occurred at Colorado General Hospital during a 3 1/2-year period. Four of the cases were due to nontypable organisms and four to type b organisms. Four were bacteremic, only two of which were type b. None of the patients had meningitis. In all instances, maternal genital tract cultures yielded H infleuzae that, when tested, was of the same serotype as the infant isolate. A survey of cervical cultures among normal and pregnant women yielded H influenzae in less than 1%. There are several possible reasons for the disparity between the apparent high incidence of neonatal infection and low prevalence of maternal carriage.

Adolescent↗