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Biomedical subjects

N Kitajima

Publications and source records attributed to N Kitajima.

At least 19 recordsLinked to original sources
PubMed2005

Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia.

BACKGROUND: An effective therapeutic strategy for functional dyspepsia (FD) has not been well-established. AIM: We investigated and compared the therapeutic effects of famotidine, mosapride and tandospirone for the control of dyspeptic symptoms. METHODS: Fully examined FD patients of outpatient clinics at seven different medical centres were enrolled in the study. They were randomly assigned to three groups based on the type of drug administered: famotidine, mosapride and tandospirone. The effects of treatment over 4 weeks were assessed by visual analogue scales. RESULTS: All of the drugs showed beneficial effects, although famotidine was the most effective for symptom relief, which was significantly greater than tandospirone, while the effect of mosapride was similar to that of famotidine. No subtype of FD showed a better response to a particular type of drug. CONCLUSIONS: For the treatment of FD, famotidine demonstrated the best therapeutic effect, followed by mosapride, while that of tandospirone was significantly lower.

Anti-Anxiety Agents↗
PubMed1999

Dynamic capture of sound motion by light stimuli moving in three-dimensional space.

A moving light stimulus produced a sensation of motion for a stationary sound stimulus presented simultaneously, which was called the dynamic visual capture by Mateeff, Hohnsbein, and Noack in 1985. The present study examined whether the moving light stimulus might induce a perceptual shift in the velocity, that is, the speed and the direction, of a moving sound stimulus. This type of the visual capture was explored in the directions where the sound stimulus moved along the motion tracks of the light stimulus: first in a horizontal and a vertical orientation and secondly in a depth orientation. Moreover, perceptual distortion of the direction of movement of the sound stimulus was investigated when the direction from which a sound stimulus moved deviated from the motion tracks of a light stimulus. It was found that the dynamic visual capture was inducible in all of three orientations, appearing more strongly in the vertical and the depth orientations than in the horizontal orientation. The perceived direction of the moving sound stimulus was greatly influenced by the direction where the light stimulus moved simultaneously and was often the same as the physical direction of the light stimulus, even when the physical motion directions of those two stimuli were perpendicular or opposite each other.

Acoustic Stimulation↗
PubMed1999

[Influence of visual attention upon sound localization].

Previous studies on audio-visual interaction such as the ventriloquism effect have indicated cognitive (or context) factors as well as sensory (or synchronous) factors could make the interaction. In these studies, however, visual attention seems to have been neglected. Thus, it has been still unknown whether the visual attention affects the interaction or not. We investigated the contribution of the attention factors to the audio-visual interaction by comparing the sound localization biases made by attentional factors and those by synchronous factors. Three subjects participated in the localization tasks in horizontal and vertical orientations. As the results, we found small influence of the attentional factors upon the interaction in the horizontal orientation, and no influence in the vertical orientation. On the contrary, the effect of the synchronous factors was larger in the vertical orientation than in the horizontal orientation. We concluded that the visual attention could affect the audio-visual interaction slightly, and that the influences of the attentional factors and the perceptual factors upon the interactions were made in the different processes.

Attention↗
PubMed1998

High-performance liquid chromatographic method for rapid and highly sensitive determination of histidine using postcolumn fluorescence detection with o-phthaldialdehyde.

A high-performance liquid chromatographic method was developed for the rapid and sensitive determination of histidine. The method is based on separation by reversed-phase ion-pair chromatography followed by highly selective fluorescence derivatization of histidine with o-phthaldialdehyde. A linear calibration curve was obtained over the range of 0.25-200 pmol per injection (10 microl) with the coefficient of variation of 0.9% at 2 pmol (n=10) and with the detection limit (SIN=8) of 25 fmol. The method was applicable to the assay of histidine in human serum. Serum histidine values obtained by the present method were in good agreement with values obtained with an amino acid analyzer.

Chromatography, High Pressure Liquid↗
PubMed1998

[Long-term administration study of propiverine hydrochloride (BUP-4 tablets) in pollakiuria and urinary incontinence].

The safety and efficacy of one-year administration of propiverine hydrochloride (BUP-4 tablets) were assessed in facilities affiliated with the Department of Urology of Yokohama City University School of Medicine. Changes in subjective symptoms showed significant improvement in mean frequency of urination in the daytime from 10.3 +/- 4.0 times before administration to 7.1 +/- 2.9 times 1 year after the start of administration, in mean frequency of voiding at night from 4.2 +/- 1.7 times to 2.1 +/- 1.1 times and in mean incidence of urinary incontinence from 2.9 +/- 2.1 times to 0.7 +/- 1.0 times. The final degree of overall improvement rate was 82.0% (41/50 cases). Adverse effects were observed 26 times in 22 patients, the incidence being 15.6% (22/141 cases). They consisted of digestive symptoms in 9.9% (6 events of dry mouth, 4 of constipation, 2 of abdominal discomfort, 2 of diarrhea and 1 of gastritis), urinary tract symptoms in 3.5% (4 of dysuria and 1 of residual urine), abnormal laboratory findings in 1.4% (increase in glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase or lactate dehydrogenase levels) and others (1.4%). These results provide further evidence of the safety and efficacy of propiverine hydrochloride (BUP-4 tablets) even when administered for a long-term in the treatment of patients with pollakiuria and urinary incontinence.

Administration, Oral↗
PubMed1994

[A case of advanced cancer of the renal pelvis effectively treated by continuous infusion of 5-fluorouracil].

We obtained a partial response to a transitional cell carcinoma (TCC) of the renal pelvis with multiple metastasis following a 24-hour continuous injection of 5-FU (5 fluorouracil) over a period of 8 weeks. After treatment we could successfully remove the primary lesion. After removal of the primary lesion, the patient lived for three months. Because the effects of this treatment, compared to those of combination chemotherapy, are mild, it is useful for elderly patients with progressive TCC.

Aged↗
PubMed1993

Cytomegalovirus mononucleosis--associated gastric ulcers in normal host.

A case of cytomegalovirus (CMV) mononucleosis associated with gastric ulcers is reported in a normal non-immunocompromised host. The demonstration of intranuclear inclusion bodies in a few gastric glandular epithelial cells contributed to the diagnosis of CMV gastritis. Extraction of DNA from the gastric biopsy specimens and the amplification of CMV-DNA by the polymerase chain reaction (PCR) showed the presence of CMV-DNA in the gastric mucosa. In situ hybridization with a probe derived from CMV genomic regions demonstrated the numerous glandular cells with CMV-DNA at the nuclear region. Treatment with a proton pump inhibitor to suppress gastric acid secretion was useful to mitigate the epigastralgia and to hasten the ulcer healing. The value of highly sensitive PCR and the in situ hybridization method to detect the CMV-DNA were emphasized for rapid and sensitive diagnosis of CMV gastritis.

Adult↗
PubMed1993

[A case of ureteritis with a course of rapidly progressing stricture].

Rapidly progressing stricture of the ureter with non-specific ureteritis is very rare and neither pathogenesis nor reliable treatment is known. We report a case of ureteritis in a 51-year-old woman with a stricture rapidly progressing over a course of 2 months. She was sent to us for left hydronephrosis. Retrograde pyelography (RP) revealed a 5 cm stricture in the left ureter. CT showed no abnormal mass in the retroperitoneum. Gastro-intestinal and gynecological inspection revealed no abnormalities. As a second RP showed 9 cm stricture 2 months later, we performed a biopsy of the ureter and examined it pathologically. There was no evidence of malignancy, but we performed a left nephroureterectomy, because of the stricture in the entire left ureter. Pathological study of the kidney and the ureter showed a non-specific inflammation of the entire urothelium without malignancy. There has been no recurrence in the right ureter.

Constriction, Pathologic↗
PubMed1992

Acinar cell carcinoma of the pancreas with elevated serum alpha-fetoprotein levels: a case report and a review of 28 cases reported in Japan.

A 60-year-old male with elevated serum AFP levels is reported. Other tumor markers apart from AFP were normal. Serum AFP did not bind to Con A or Lentil-lectin by affinity chromatography. Abdominal ultrasonography, computed tomography and endoscopic retrograded cholangiopancreatography demonstrated a tumor extending from the body to the tail of the pancreas. The tumor was strongly suggested to be an acinar cell carcinoma of the pancreas, based on the histological findings of the resected specimen. The peroxidase-antiperoxidase method showed cancer cells to be positive for AFP. In Japan, only 27 cases of pancreatic cancer with elevated serum AFP level have been reported. This is the first Japanese case of pancreatic cancer in which the binding of serum AFP to lectins was investigated.

Carcinoma↗
PubMed1992

[Age-related effects of gastroduodenoscopy on arterial oxygen saturation].

Although endoscopy is widely used for safe and accurate examinations of gastroduodenal disease cases, several investigators reported arterial oxygen desaturation occurring during endoscopy. Endoscopy-induced oxygen desaturation is hazardous because it increases the risk of cardiac arrhythmia. This study is designed to investigate whether gastroduodenal endoscopy causes remarkable oxygen desaturation in elderly patients in comparison with younger ones and to study whether nasal oxygen administration can prevent it. Forty-four patients over 61 years old and 37 patients younger than 60 were divided into two groups, to one of which 100% oxygen (2 l/min) was administered through nasal prongs. During endoscopy, blood pressure, pulse rate, and arterial oxygen saturation (SaO2) were recorded at one-minute intervals by a pulse oximeter. Intubation of the endoscope caused a transient drop in oxygen saturation both younger and older patients with greater drops in older subjects (1.7 +/- 0.4% in the young and 3.3 +/- 0.8% in the old groups). In the older groups, two out of 20 patients who had no oxygen administration showed a saturation decrease of over 7%. On the other hand, no younger subject showed such a large degree of oxygen desaturation. Oxygen administration effectively prevented the endoscopy-induced desaturation both in younger and in older patients. In summary, the results of this study suggested that older subjects had a greater decrease of oxygen saturation during gastroduodenofiberscopy and that oxygen administration is useful to prevent the endoscopy-induced desaturation.

Aging↗
PubMed1992

Gastroesophageal reflux after endoscopic injection sclerotherapy.

The effect of sclerotherapy of esophageal varices on the gastroesophageal reflux was studied. Gastroesophageal reflux was monitored by a 24-h pH-monitoring catheter introduced into the distal esophagus. The results of pH monitoring of 16 patients who underwent sclerotherapy were compared with those of 21 patients with untreated varices. Seven of the 16 treated patients showed high occurrence rates of gastroesophageal reflux comparable to those observed in cases with severe reflux esophagitis. In the untreated group, only one patient showed pathological reflux (there was a significant difference between treated and untreated groups; p less than 0.01). When the level of reflux was compared with factors that might influence sclerotherapy-induced gastroesophageal reflux, there was a positive correlation between the magnitude of reflux and amount of sclerosant injected paravariceally in the submucosal tissue (p less than 0.05). The results indicate that the paravariceal injection of sclerosant for the treatment of esophageal varix may cause pathological gastroesophageal reflux after sclerotherapy is completed.

Analysis of Variance↗
PubMed1991

Two cases of gastric antral vascular ectasia--response to medical treatment.

Two patients with severe iron deficiency anemia and gastric antral vascular ectasia (GAVE) are reported. The anemia caused by the chronic blood loss from the abnormally dilated mucosal and submucosal capillary veins in the gastric antrum was unresponsive to oral iron supplementation. However, one of the patients was successfully treated with intramuscular injection of (Asu1,7) eel calcitonin. The other one was treated by oral prednisolone with resulting improvement iron deficiency anemia. The possible mechanisms of successful calcitonin and prednisolone treatments on chronic blood loss from GAVE is discussed.

Aged↗
PubMed1991

Arterial oxygen saturation, blood pressure, and pulse rate during upper gastrointestinal endoscopy--influence of sedation and age.

We studied the effect of sedation by I.V. meperidine on blood pressure, pulse rate, and arterial oxygen saturation during upper gastrointestinal endoscopy. Meperidine increased the tolerance of the patients and attenuated the endoscopy-induced rise in blood pressure and pulse rate. Arterial oxygen saturation was transiently depressed in the first few minutes of the endoscopic procedure even without sedation, and meperidine administration did not aggravate this oxygen desaturation. Therefore, meperidine may be a favorable sedative for upper gastrointestinal endoscopy because its treatment increases the tolerance of patients and decreases cardiac oxygen demand without decreasing arterial oxygen saturation.

Age Factors↗
PubMed1991

Primary chylopericardium with pulmonary shadow and large granular lymphocytosis: a case report.

A 79-year-old man with primary chylopericardium associated with large granular lymphocytosis was followed for more than 26 years. Except for development of dyspnea on exertion during the past four years and more recently cough with sputum production, he has remained largely asymptomatic over this interval. Based on detailed examinations of cellular and humoral immunity, we speculate that increased natural killer cell activity and an increased number of large granular lymphocytes circulating in his peripheral blood represent a reactive response to production of various cytokines secondary to persistent loss (? chyloptysis) and sequestration of central lymph.

Aged↗
PubMed1991

A case of gastric plasmacytoma: genetic analysis and immunofixation electrophoresis.

A case of early gastric plasmacytoma in a 66-yr-old woman is reported. The demonstration of monotypic IgM lambda immunoglobulin in plasma cells infiltrating the gastric antrum contributed the histological diagnosis. Genetic analysis of the tumor cells confirmed the presence of a monoclonal neoplastic population of plasma cells in the tumor. Monoclonal immunoglobulin (IgM lambda) was demonstrated in serum, not by conventional immunoelectrophoresis, but by a highly sensitive immunofixation electrophoresis technique. Serum monoclonal immunoglobulin disappeared after subtotal gastrectomy. The value of immunofixation electrophoresis of serum protein and DNA analysis of tumor cells was emphasized for the diagnosis of gastric plasmacytoma.

Aged↗