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N Klüken

Publications and source records attributed to N Klüken.

13 recordsLinked to original sources
PubMed1986

[Effects of horse-chestnut seed extract on transcapillary filtration in chronic venous insufficiency].

The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized placebo-controlled crossover double-blind trial of 22 patients with proven chronic venous insufficiency by measuring the capillary filtration coefficient and the intravascular volume of the lower leg by venous-occlusion plethysmography. Three hours after taking two capsules of Venostasin (600 mg; each capsule containing 50 mg aescin) the capillary filtration coefficient had decreased by 22%, whereas after administration of an identical-looking placebo capsule it rose but slightly over three hours. The difference in the effect of Venostasin and placebo is statistically significant (P = 0.006). The intravascular volume was reduced 5% more after Venostasin than the placebo, but this is not statistically significant. It is concluded that Venostasin has an inhibitory effect on oedema formation via a decrease in transcapillary filtration and thus improves oedema-related symptoms in venous diseases of the legs.

Capillary Permeability↗
PubMedDate not supplied

[Aspects of defibrinogenation therapy].

Fibrinolysis threatment works by means of enzymatic action. It is an effective therapy for occlusive disease of the arteries at Fontaine's stages III and IV. New developments in this treatment will be of interest to phlebologists in the near future. No studies have been reported in the world literature that broaden the present indications : critical study is still required.

Ancrod↗
PubMedDate not supplied

[Deep vasculitis].

The author gives a definition of the term "vasculitis". Histopathological modifications are the result of a disturbance in the barrier function exerted by the vascular endothelium. The disturbances observed are characterized by piles of endothelial or intimal debris associated with a perivascular inflammatory reaction of the connective tissue and the appearance of a resorption granuloma. Whether superficial or deep, vasculitis can become "nodular" in appearance and is then characterized by "nodules" or "patches". In order to implement aetiological treatment, it is necessary to look for the causative agent: an infectious, drug or bacterial allergen, or hypertension is frequently involved.

Humans↗
PubMedDate not supplied

[Clinical picture and treatment of the Raynaud syndrome of the upper extremities].

Raynaud's disease occurs in different clinical forms, which are not specific to the vascular spasm which characterizes the disease. This spasm virtually always develops in the same manner. Clinical aspects depend on the underlying pathology, which will define treatment. Therapeutic efficacy in Raynaud's disease is discussed. Current interest focuses on serotonin antagonists.

Cold Temperature↗
PubMedDate not supplied

[The physiology and physiopathology of the venous system in the obese].

The question of knowing to what extent varices occur more frequently in obese, rather than in non-obese, patients is answered variously in the epidemiological studies carried out. But if pathological venous conditions originate in, or are aggravated by, obesity, the question is raised: to what extent is the venous circulation modified by obesity? The authors discuss the factors at play in venous circulation in the obese patient. The effect of super alimentation on the venous system is demonstrated in the autopsy statistics on the occurrence of fatal pulmonary embolism, compared with the general nutrition index.

Humans↗
PubMedDate not supplied

[Clinical picture of acrosyndromes].

Classification and clinical symptomatology of acrosyndromes. Acrosyndromes are compared to angiolopathies. They have been well studied on the skin, but they also affect other organs. According to our current knowledge, this mostly concerns organic angiolopathies. As long as we do not have a more advanced view of extra-cutaneous localizations, we must keep the classification criteria established after the skin localizations. This classification protocol is presented and justified. The clinical symptomatology of acrosyndromes is presented according to this classification protocol.

Cyanosis↗
PubMedDate not supplied

[Pathologic anatomy of white atrophy].

Milian's respectively aetiological and pathogenic hypotheses, based on the infectious origin of this disease, such as tuberculosis or syphilis, have not been confirmed. In almost every case there has proved to be chronic venous deficiency. The histomorphological deterioration shows, as well as the characteristic signs of cutaneous atrophy, the vessel affection developing towards dilation, but also the parietal processes moving towards obliteration. These processes do not correspond to vasculitis, as described by Ruiter. For this reason, we do not go along with those authors associating these histological deteriorations with vasculitis. And we therefore justify our claim that white atrophy cannot be considered as an angiolopathy.

Atrophy↗
PubMedDate not supplied

[Defibrination treatment of progressive scleroderma].

The authors report about the defibrination therapy with the enzyme préparation Arwin in sclerodermia progressiva. From 16 patients with sclerodermia progressiva, 9 patients showed a clinically good result. Three patients showed a certain improvement, but objectively, the results are doubtful. Four of the patients did not react to the therapy clinically nor in the applied tests. We have tried to prove the effect of the enzyme preparation Arwin in patients with sclerodermia progressiva with venous occlusion plethysmography and by isotope Technetium 99 with the use of a Gamma-camera. The results will be reported.

Ancrod↗