Biomedical subjects

N Koifman

Publications and source records attributed to N Koifman.

3 recordsLinked to original sources

PubMed2000

[Penile cancer: flow cytometry study of ploidies in 90 patients].

OBJECTIVE: To evaluate prospectively 90 consecutive cases of squamous cell carcinoma of penis, referred to our Institute, by flow cytometry analysis of cellular DNA content. To compare deoxyribonucleic acid (DNA) flow cytometry with clinical and pathological variables to determine the prognostic significance of this analysis to guide the selection of patients at high risk for development of lymph node metastases. PATIENTS AND METHODS: We determined the nuclear DNA of tissues in fresh biopsy specimens of 80 patients diagnosed histologically as invasive squamous cell penile carcinoma and in fresh biopsy specimens of 10 patients with verrucous carcinoma of penis. Samples were analyzed with a FACScan flow cytometer, equipped with a doublet discrimination module, using the CellFIT software package for data acquisition and analysis. RESULTS: The DNA pattern was diploid in all samples excised from patients with verrucous carcinoma. According to histological type the frequency of aneuploidy was 5.5% (1 of 18) in well differentiated carcinoma, 28.8% (17 of 59) in moderately differentiated carcinoma and 66.6% (2 of 3) in poorly differentiated carcinoma. CONCLUSION: The frequency of DNA aneuploidy showed correlation with histological type of invasive squamous cell carcinoma of the penis. Preliminary analysis suggests that patients with high DNA index may be at increased risk of metastatic involvement.

Carcinoma, Squamous Cell↗

PubMed1999

[Cancer of the urethra in women: experience of the National Institute of Cancer of Brazil: 1992-1997].

OBJECTIVE: Describe the results of surgery, radiation therapy and chemotherapy for treatment of primary malignant neoplasms of female urethra. PATIENTS AND METHODS: Since 1982, 31 patients with urethral cancer were evaluated at our institution (follow-up ranging from 0 to 127 months). Ten patients were treated with external beam irradiation and 1 patient received preoperative therapy after surgery. Two patients refused treatment and 1 received chemotherapy. Three patients presented with disseminated metastatic disease at the first examination received exclusively palliative treatment. RESULTS: Five patients have survived from 3 to 10 years following treatment without recurrence. Of 31 patients 18 developed distant metastases during the first 24 months of follow-up irrespective of treatment employed. CONCLUSION: With exception of primary melanoma, prognosis was not related to histologic features. Patients who underwent surgery and radiotherapy had a better survival rate than did those who received radiotherapy alone. Total urethrectomy with appendico-vesicostomy can be an alternative surgical method for entire urethral ivnasive lesions without cystourethrectomy and preserving urinary continence.

Adult↗

PubMed1984

Auditory perception in early lateralized brain damage.

In a study of hemispheric dominance for the perception of speech the performance of 28 young children with congenital or infantile hemiplegia was compared with that of their normal peers and recently brain damage nonaphasic adults. Our results confirm Goodglass's findings that in children with early left hemisphere damage the transfer of dominance for speech processing is completed in childhood, and they show that this process of hemispheric transfer can be completed by 3 years of age. Comparison with results on adults with CVA provides additional evidence that in early lateralized brain cognitive functions normally dominant in one cerebral hemisphere are developed in the alternative hemisphere in a way that apparently does not happen later in life.

Adult↗