Biomedical subjects

N Kolebinov

Publications and source records attributed to N Kolebinov.

15 recordsLinked to original sources

PubMed1990

[Bilateral adrenal metastases with the clinical manifestations of hypocorticism in rectal cancer].

Metastases in the suprarenal glands are being found in patients with neoplasms but symptomatic hypocorticism is described in single cases only. Computed tomography allows the diagnosis of suprarenal metastases causing hypocorticism while the patients are still alive. A case of a man, 40 years of age, with rectal carcinoma and clinically manifested hypocorticism due to bilateral suprarenal metastases is presented.

Adenocarcinoma, Scirrhous↗

PubMed1989

[Long-term observation of a case of Hand-Schüller-Christian disease].

A case is presented of a 28-year-old man with Hand-Schüller-Christian's disease whose initial manifestations were skull bones lesions and a diffuse interstitial fibrosis. Three years later the patient developed diabetes insipidus without changes in the hypothalamic-hypophysial region on computed tomography. Some features of the clinical picture are discussed.

Adult↗

PubMed1988

[Our experience in treating diabetes mellitus with the preparation Minidiab].

55 patients with non-insulin-dependent diabetes mellitus were treated with the new oral drug Minidiab. In 58.2% of the patients the carbohydrate metabolism was influenced. No relation between the immunoreactive insulin increase and the effect of the treatment was found. An extrapancreatic action of the drug is suggested as its hypoglycemic activity.

Adult↗

PubMed1987

[Serum enzymes in hypothyroidism].

The following parameters were studied in 27 newly diagnosed and not treated patients with primary hypothyroidism: TTH, creatine kinase (CK) with MB isoenzyme, lactate dehydrogenase (LDH) with isoenzymes LDH1 and LDH5, aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) before and after 20-day substitutive therapy. It has been established that the enzymes were increased in about 60% of the untreated patients, and the typical enzyme constellation for hypothyroidism consisted of CK with MB isoenzymes, ASAT and LDH1. The myocardial isoenzymes were normalized within the period of substitutive therapy. The enzymes were established to be elevated only in the patients that had increased CK. The follow up of the above enzyme constellation before and during the initial phases of the treatment of hypothyroidism could provide considerable possibilities of differential diagnosis with ischemic heart disease, often manifested during that period. The determination of CK in advance would be a screening determining the necessity of studies on the enzyme constellation.

Adolescent↗

PubMed1987

[Urinary excretion and renal clearance of several specific plasma proteins in diabetics].

The 24-h urine excretion and renal clearance of albumin, alpha I-acid glycoprotein, transferrin, IgG, IgA and haptoglobin were studied in 30 albustix-negative diabetics with no clinical data for diabetic nephropathy aiming at the precise characterization of proteinuria in patients with diabetes mellitus. The diabetic patients were divided into two groups - 15 patients with newly diagnosed diabetes and 15 - with a longer duration of diabetes. Thirteen healthy subjects, at the same mean age, served as a control group. The results reveal increase of the clearances and 24-h excretion of the proteins studied in the patients with diabetes mellitus, in those with a short duration of the disease including, with authentic difference for albumin, transferrin, IgG and haptoglobin among the patients with a longer duration of the disease and the healthy controls and authentic difference for albumin between those with the newly diagnosed diabetes and the healthy control. The possible prognostic significance of the indices studied is discussed as well as their importance for the early diagnosis of diabetic nephropathy.

Blood Proteins↗

PubMed1976

[Effect of climatic exposure and physical activity on plasma cortisol levels and urinary 17-hydroxycorticosteroid excretion in patients with hypertension].

Decrease in arterial pressure, mainly manifested in the first 5-10 days, was established in 111 patients with hypertension disease in functional and initial organic stage in the conditions of moderately high mountain (1870 m above sea level) after 25/20 days of complex climatic treatment including: active motor regimen, sun-air exposure and Pevzner diet No 10. Simultaneously the excretion of 17-hydroxicorticosteroids was increased in daily urine. Suprarenal cortex stimulation is best manifested after the first week and is kept till the end of the treatment. Cortisol plasma level was elevated in 42.7 per cent of the patients with hypertension disease with initial values under 15 mkg/100 ml plasma after three hours moderately severe physical activity, carried out in physiological thermal conditions and was decreased with 25.9 per cent with initial levels over 20 mkg/100 ml plasma. Parallely, 17-hydroxicoricosteroids secretion in urine was decreased as well as the systolic and diastolic arterial pressure.

17-Hydroxycorticosteroids↗

PubMed1976

[Determination of free and protein bound cortisol, transcortin binding capacity and adrenocorticotropic hormone in the plasma of patients with hypertension].

The total non-conjugated plasma cortisol in 60 patients with hypertension disease (HD)is 17.5 mkg/ml. The free non-conjugated cortisol represents 8.45 per cent of the total - 1,5 mkg%, considerably (p less than 0.0001) higher than that in healthy subjects. Protein conjugated cortisol is 16.0 mkg%. The bounding capacity of transcortin the plasma of hypertonics is considerably decreased (p less than 0.0001) - 15.8 mkg (in healthy - 18.5 mkg) per 100 ml. ACTH level in the plasma of patients with HD is 32.0 pg/ml, considerably higher than that in healthy (25.8 pg/ml, p less than 0.0001). The elevation of the biologically active cortisol fraction in plasma of hypertonics is a function both of hypothalamo-hypopheseal stimulation and of transcortin level. That latent hypercortisolism is admitted to be manifestation of hypothalamo - hypopheseal superstimulation by increased ACTH secretion, in case of confirmed cerebro-hypothalamic disturbances in patients with hypertension disease.

Adolescent↗

PubMed1976

[Cortisol secretion rate (CSR) in hypertension and endocrine patients].

With the method of isotope dilution the circadian cortisol secretion was determined in 22 patients with hypertonic disease--28.35 mg/24 h, elevated versus CSR in healthy subjects-16.63 mg/24 h. CSR is elevated also in 5 patients with bilateral adenocortical hyperplasia and with suprarenal cancer. The patients with diencephalic syndrome, progressing according to the type of Cushing disease have elevated absolute values of CSR, but recalculated per square meter of body surface and per gram creatineine excreted in 24 h-CSR proved to be normal-about 12 mg/24 h.

Adrenal Cortex Neoplasms↗

PubMed1975

[Changes in the corticosteroids and their alpha-ketol metabolites in the urine of hypertension patients treated with metopirons].

Results from the examinations of 20 hypertonics treated with methtopyron 4.5 g/24 h are presented. The values of S, THS, THF, THE and aldosterone in urine are determined, parallelly with plasma cortisol prior to and post hydroxilase blocker. An elevation of urinary THS and DOK was found, with depressed levels of aldosterone in urine and plasma cortisol. Those four indices permit a considerably precise assessment of involving and notinvolving of the different links of hypothalamo-hypophyseal-suprarenal system and the eventual location of the disturbance. Three of the hypertonics did not elevate THS and DOK in urine after methopyron, in spite of the inhibition of the urinary aldosterone and plasma cortisol. That was admitted to be a manifestation of a disturbance in the hypothalamo-hypophyseal functional reserves which might participate in the development and maintenance of the hypertensive disease.

Adolescent↗

PubMed1974