Biomedical subjects

N Konstantinidis

Publications and source records attributed to N Konstantinidis.

7 recordsLinked to original sources

PubMed1996

[Congenital leukemia--personal experience].

Congenital leukemia is a very rare form of acute leukemia and up to now more than 100 well documented cases have been published. Symptoms and signs of the disease may be faintly differentiated and be a differential diagnostic problem for a long period of time in comparison to other common diseases of the newborn. This is a case report on two newborns with congenital leukemia. It was an acute non-lymphoblastic leukemia in the first case, and acute lymphoblastic leukemia in the second. In both cases there were nonspecific manifestations of the disease (no weight gaining, hemorrhagic enterocolitis). In both cases polyhemotherapeutic protocols were performed. In the first case only partial remission occurred and death occurred during the hemathologic recidive of the disease. In the second case, 15 months after the diagnose of congenital leukemia has been established, complete remission is in course.

Humans↗

PubMed1996

[Infiltration of the testes in acute lymphoblastic leukemia in childhood--personal experience].

According to various literature data testicular leukemic infiltration occurs in 5-40%, while the mean time for testicular recurrence is 36 months. Hematologic recurrence usually occurs in the interval from 1-6 months. Although testicular leukemic infiltration clinically occurs as an isolated recurrence of leukemia, it usually presents only a clearly marked spot in the general recurrence of the disease. It is a painless enlargement of one or both testes. The diagnosis is made ultrasonographically and by histopathologic examination of the biopsied testicle tissue. This paper deals with 4 patients with acute lymphoblastic leukemia and testicular recurrence. In 2 patients the testicular recurrence occurred as a part of the general recurrence of the disease, while in the other 2 at the time of testicular recurrence diagnosis, the bone marrow was regular. All 4 patients were treated with combined radiotherapy and chemotherapy, in 3 cases successfully.

Child↗

PubMed1993

[Adolescent mortality in Vojvodina].

The aim of the study was to determine the mortality rate of adolescents in Vojvodina and analyze the most common causes of their death. For the analysis we used the data from the Health Statistics Annual and from individual statistics reports. The observation period was between 1986 and 1988. The mean mortality rate of the adolescents in Vojvodina for that period was 6.7/100000. The leading cause of death (54.74%) was accidents (mostly traffic accidents), malignant diseases and finally cardiovascular diseases. The mortality rate was higher among older adolescents. It was 4 times higher in the outpatients compared to the inpatients and caused either by the severity of the injury and/or inadequately handled injuries. For the highest percentage of the accidents responsible were external factors among which risk behavior of the young played a significant role. The task of the society is to take appropriate measures which would reduce the role of the external factors as a cause of death.

Adolescent↗

PubMed1991

[Drug poisoning in children in Vojvodina].

Epidemiological characteristics of acute drug poisoning in children were investigated over a period of two years (1988-1989). The total number of poisonings was 450. Among causes of poisoning psychopharmaca, especially benzodiazepine, came first (33.3%). They were followed by drugs affecting the nervous system (9.1%), usually by analgoantipyretics, and by drugs affecting the cardiovascular system (7.8%). In 10.6% of the cases poisoning was due to two or more drugs. In 12.3% of the poisonings drug was unknown. Sodium fluoride was the most frequent single cause of acute poisoning. The average age of the poisoned children was 5.1 years. Poisoning with drugs was more frequent among girls than among boys (55:45%). In more than half poisoning accidents there was no one present when poisoning occurred. A major number of poisonings were an attention-getting gesture or a suicidal attempt. There were 11 cases of repeated poisoning with the same drug.

Adolescent↗

PubMed1990

[Morbidity and mortality in adolescents in Vojvodina].

Adolescents. The aim of this study was to analyze the morbidity and mortality of adolescents in SAP Vojvodina. For the analysis, data was used from the statistical yearbooks on the health protection of the population and data from individual statistical reports. The period from 1980 to 1986 was observed. In order to more easily follow the morbidity and mortality, and for a better insight into the pathology, the adolescents were divided into 2 age groups; the younger one from 10 to 14 years of age, and the older one from 15 to 19. Adolescents in Vojvodina mostly ail from respiratory diseases, illnesses of the digestive tract, and infective diseases, but a significant role in the morbidity is also taken by injuries and poisoning. Adolescents of the age group from 10 to 14 years, get sick more often. In SAP Vojvodina 156 adolescents die annually. The highest mortality is due to injuries and poisoning (16.36/1,000,000), and after that comes the mortality due to neoplasms (5.84/1,000,000), and the diseases of the respiratory and circulatory system (3.5/1,000,000). Mortality is higher in the adolescent group from 15 to 19 years of age. With this study only a partial insight was achieved into the pathology of the adolescent age group. In order to attain a full insight, it is absolutely necessary to actively and prospectively follow the health state of adolescents and the conditions of environment.

Adolescent↗

PubMedDate not supplied

[Malignant ovarian tumors in childhood and adolescence in Novi Sad (1946-1989)].

In the period from 1946-1989, at the Department of Gynecology and Obstetrics University of Novi Sad, 79 ovarian tumors in children and adolescents were registered. There were 10 (12.6%) malignant tumours. The most common were dysgerminoma and carcinoma (total 6-7.6%). The treatment depended on the extent of the disease at the time of diagnosis (surgery, irradiation, chemotherapy or combination).

Adolescent↗

PubMedDate not supplied

[Asphyxia and intracranial hemorrhage in high-risk neonates of various gestational ages].

The aim of this study was to compare the type and severeness of brain damage in vitally most endangered newborn infants of different gestational age. We retrospectively analyzed the records of 75 newborn infants treated and decreased at the Department of Intensive Care and Therapy of the Institute of Children's and Adolescents' Health Care in Novi Sad. Diagnoses of hypoxic-ischemic lesion and intracranial hemorrhage in the case of grade four PVH-IVH (periventricular hemorrhage-intraventricular hemorrhage) were established by ultrasonography of the brain and lumbar punction in the case of subarachnoid hemorrhage. These diagnoses were confirmed after forensic-medical expertise. The volume and degree of the damage were compared in regard to the gestational age, Apgar score and time of initial mechanical ventilation and initial parameters of the mechanical ventilation, as well as to values of acido-basic status, concentration of gases in arterialized capillary blood and type of lung damage which always occurred in these patients. In all 75 examined newborns perinatal asphyxia was the dominant etiologic factor for the course and outcome of the disease (in all patients Apgar score was 4 or less). 75% of examines were born before 32 weeks gestation and of low or very low body weight, whereas 72% had intracranial hemorrhage (periventricular-intraventricular) and hypoxic-ischemic damage of the brain parenchyma. The rest of examinees had intracranial hemorrhage or hypoxic-ischemic damage of the brain parenchyma. Although 92% of examinees received mechanical ventilation in the first 3 days of life, only 20% of newborn infants had satisfactory values of acido-basic status and gas concentrations in the blood. We concluded that in the most severe cases of perinatal asphyxia, especially in preterm newborns of low or very low body weight, both intracranial hemorrhage and hypoxic-ischemic encephalopathy develop. Damages of other organs or systems of organs, especially lungs, as a rule contribute to infaust ending.

Asphyxia Neonatorum↗