PubMed Health⌕ Search

Biomedical subjects

N Kovacević

Publications and source records attributed to N Kovacević.

At least 19 recordsLinked to original sources

Preliminary assay on the antioxidative activity of Maydis stigma extracts.

Antioxidative effects of Maydis stigma methanolic extracts were studied on the level of lipid peroxidation in liposomes, induced by Fe(2+)/ascorbate system and measured spectrophotometrically by the TBA-test. The most significant inhibition of lipid peroxidation was observed when methanolic extracts of fully developed, mature corn silk were applied. The same test, performed after fractionation of the most active extract, showed that most of the activity was concentrated in fractions with moderate lipophilicity, containing phenolic acids, flavonoid aglyca and resembling monosides.

Antioxidants↗

Preliminary assay on the antioxidative activity of Laurus nobilis extracts.

Antioxidative activity of Laurus nobilis leaves, bark and fruit methanolic extracts (crude and defatted) were studied on the level of lipid peroxidation in liposomes, induced by Fe(2+)/ascorbate system and measured spectrophotometrically by the TBA-test. The most significant inhibition of lipid peroxidation was obtained with methanolic extracts of laurel bark (70.6% of inhibition was obtained with 1.0 mg of crude extract).

Antioxidants↗

[Topographic and structural characteristics of the minor duodenal papilla].

The study of minor duodenal papilla topography and structure was carried out on 36 fresh autopsy specimens of human duodenopancreas. We performed precise measurements of its distance to the major duodenal papilla and to the superior duodenal flexure. There was no correlation between the position of the minor papilla and the incidence of duodenal ulcer disease. Microdissection and histological staining of the minor papilla did not reveal an anatomically defined sphincter around the terminal portion of the accessory pancreatic duct. All the specimens of the minor papilla contained within acini of pancreatic tissue. A terminal dilation of the accessory pancreatic duct was found in 22% of the cases.

Adult↗

[Surgical treatment of liver metastases of colorectal carcinoma].

Colorectal carcinoma metastasizes into the liver, but liver-only metastases are infrequent. Liver-only metastases are seen mainly from colorectal carcinoma. This is the only metastatic disease where treatment aimed only or mainly at the liver metastases is employed with curative intent. If liver resection for colorectal metastases is done by an experienced team, adhering to predefined indications, five year survival ranges from 30-40%, operative mortality is 3-5% and the postoperative morbidity is acceptable. New diagnostic techniques have been introduced and indications for liver resection extended. This paper presents the current limitations and possibilities for the surgical management of colorectal metastases in the liver.

Carcinoma↗

A model of in vivo dosimetry and quality assurance analysis of total body irradiation in Zagreb.

The aim of the study was to develop a systemic and simple method for determination of midplane dose factors and lung correction factors, suitable for semiconductor 60-Co total body irradiation (TBI) in vivo dosimetry, based on input (entrance) and output (exit) dose readings. A theoretical model of anthropomorphic phantoms of cylindrical ellipsoid shape made it possible to generalize the applicability to any individual case of the real patient's data. Also, the quality assurance analysis of dosimetric results of 230 patients who had undergone TBI during a 10-year period, was performed. The ratio of the mean measured dose values for all locations in all patients and stated dose (12.45 Gy in 3 days, 3 fractions) was 0.998, SD 0.033. The upper limit of the total combined uncertainty of TBI midplane absorbed dose, including all locations and all sources of error, amounted to 9.4%.

Humans↗

[Gallbladder motor function studied by modified infusion cholescintigraphy method after gastric and duodenal surgery].

Estimation of the gallbladder (GB) motility disorders after gastric surgery has not yet been assessed because of the shortage of the reliable diagnostic methods. The aim of the study is introduction, modification and establishment of the infusion cholescintigraphy into clinical practice and its performance in the groups of patients with gastric resection (RVBI i RVBII), total gastrectomy and patients after gastroplasty. Obtained data produced information about motility disorders caused by billateral truncal vagotomy, lack of the food transit through duodenum and if the motility disorders are the same in different time periods after operation. In groups of patients without truncal vagotomy (RVBI and RVBII), minor motility disorders are registered in comparison to the groups after truncal vagotomy. In the period of 6 months after surgery, higher motility disorders are registered in the group of patients with total gastrectomy, while after 9-12 months GB motility completely recovers. Groups with preserved transit of food through duodenum (RVBI and gastroplasty), has minor motility disorders in comparison to the group without transit of food through duodenum (RVBII and total gastrectomy). By introducing infusion cholescintigraphy, reliable method for the GB motility assessment is obtained.

Adult↗

[Retroperitoneal sarcoma].

Clinical experience in the treatment of retroperitoneal soft tissue sarcomas during period 1978-1987 is presented. The material consists of 64 patients with the male predominance (60.94%), and the peak occurrence in the forth and fifth decade of life. The difficulties in the diagnostic of these tumours are mostly caused by unspecific clinical picture, which is usually cleared with the stage of inoperability. Modern diagnostic approach, using echotomography and angiography enables earlier diagnosis. The most often seen histological pictures in this series are: M. Hodgkin (28.14%), Liposarcoma (25%) Lympho and fibrosarcoma (twice 12.5%), and the other forms are rarely encountered (1-3%). The operability is very low, and the radical operation is performed only in 16 cases (25.50%), and exploratory procedures are performed in 44 (68.75%). In the rest of cases a reduction of bulk mass of tumour was performed. The 5 year survival in the radically operated is present in 25% (4 patients) what is in accordance with the literature. In the cases with exploration or partial resection, the average survival is 4.5 months, in spite of some longer survivals in the group with Hodgkin's disease, mostly because of the modern cytostatic treatment. Intermediate postoperative mortality is 3.12% (2 patients). In recent years, the more aggressive surgical approach is advised, resulting in better outcome.

Adolescent↗

Simultaneous approach and avoidance learning in the teleost marine fish Serranus scriba Cuv.

The ability of the fish to discriminate between constant light (the conditional stimulus of food) and flickering light (the conditional stimulus of a painful electric shock) administered in random order during the same experimental sessions was investigated. Approaching the light for food and avoiding the shock by moving away from the light could be tought simultaneously, approach learning being faster.

Animals↗

[Mediastinal pseudocyst of the pancreas].

The authors present two cases of successfully treathed mediastinal pseudocysts of the pancreas. This localisation is very rare (13 cases of te literature). The diagnosis was proved by x-ray examinations: chest PA and profile, esophago-gastroduodenum, scanning of liver, and transthoracic punction of the cyst with laboratory examination (analysis of the cyst liquid). We were two methods of surgically intervention. The method presents two cases at 22 C+internal drainage used in the one case and the method of external drainage in the second. In our opinion, pathophysiological aspects prefer title: pancreas pseudocyst penetrate in the thorax.

Adult↗