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Biomedical subjects

N Kulaylat

Publications and source records attributed to N Kulaylat.

7 recordsLinked to original sources
PubMed2001

Symptomatic rickets in adolescence.

AIM: To describe 21 cases of symptomatic rickets in adolescents. METHODS: The setting was a primary and secondary care hospital in Saudi Arabia providing medical care to Saudi Arab company employees and their families. Cases of symptomatic rickets diagnosed between January 1996 and December 1997 in adolescents aged 10 to 15 years were assessed with respect to clinical presentation, biochemical and radiological evaluation, dietary assessment, and estimation of sun exposure. RESULTS: Symptomatic rickets developed in 21 adolescents (20 females), with a prevalence rate of 68 per 100 000 children years. Presentation included carpopedal spasms (n = 12), diffuse limb pains (n = 6), lower limbs deformities (n = 2), and generalised weakness (n = 1). Biochemical findings included hypocalcaemia (n = 19), hypophosphoraemia (n = 9), raised serum alkaline phosphatase (n = 21) and parathormone (n = 7), and reduced 25-hydroxyvitamin D concentrations (n = 7). Radiological studies were suggestive of rickets in only eight children. All children had an inadequate dietary calcium and vitamin D intake. All but one had less than 60 minutes sun exposure per day. CONCLUSION: Even in sunny climates, adolescents, especially females, can be at risk of rickets. Hypocalcaemic tetany and limb pains were the most common presenting symptoms. Radiological evidence was not present in every case.

25-Hydroxyvitamin D 2↗
PubMed1999

Is gastric lavage needed in neonates with meconium-stained amniotic fluid?

UNLABELLED: We compared the incidence of complications from meconium-containing gastric fluid in a group of neonates born with meconium-stained amniotic fluid (MSAF) who did not routinely have gastric lavage prior to feeds, versus a group who had elective gastric lavage before the first feed. In the first group, 275 neonates born with MSAF were fed without prior gastric lavage. While 13 developed feeding problems, the other 262 infants (95%) who did not undergo routine gastric lavage remained free of later feeding difficulties or secondary meconium aspiration. In the second group, all 227 neonates with MSAF had elective gastric lavage performed after birth. All remained free of later feeding difficulties or secondary meconium aspiration. CONCLUSION: Our data suggest that gastric lavage is not necessary in most neonates born with meconium-stained amniotic fluid, regardless of the thickness of the meconium-stained fluid, as no complications from meconium-containing gastric fluid were observed.

Amniotic Fluid↗
PubMed1998

Neonatal circumcision: when can infants reliably be expected to void?

OBJECTIVE: Analysis of factors influencing voiding after neonatal circumcision. DESIGN: Prospective study of the following factors in 200 circumcised infants: birth weight, gestational and postnatal age, type and timing of feeding before the procedure, and timing of last voiding before circumcision. RESULTS: There was no significant difference in the age when circumcision was performed between breastfed infants (6 and 60 hours) and in those formula-fed (8 and 130 hours). All infants voided after circumcision, with 75% of breastfed infants and 100% of formula-fed infants voiding within 8 hours of the procedure. Breastfed infants voided up to 8 hours after the procedure, compared with up to 6 hours in formula-fed infants, but without a significant difference. The interval between last feed before the procedure and the time of voiding after circumcision was significantly shorter in formula-fed infants (1 to 9 hours) than in breastfed infants (2 to 21 hours). The interval between precircumcision and postcircumcision voiding was also significantly shorter in formula-fed infants (3 to 12 hours) than in breastfed infants (1 to 23 hours). Ninety percent of formula-fed and 64% of breastfed infants voided within 10 hours of the last voiding before circumcision. No infants aspirated during the procedure, regardless of the time of the last feed. No hemorrhagic, infectious, or surgical complications of circumcision were observed. CONCLUSION: Postoperative voiding time is predictable. Healthy infants who undergo an uncomplicated circumcision can be discharged before voiding occurs.

Bottle Feeding↗
PubMed1997

High incidence of Down's syndrome in infants of diabetic mothers.

The incidence of Down's syndrome was studied in 1870 infants of diabetic mothers out of 22,300 neonates born between January 1987 and April 1994 in our institution. All pregnancies were screened for diabetes and all cases of Down's syndrome were confirmed by chromosome analysis. Down's syndrome (all trisomy 21) was diagnosed in 35 infants: seven were born to mothers with gestational diabetes and 28 to non-diabetic mothers. The incidence of Down's syndrome was higher in infants of diabetic mothers (3.75 per 1000 v 1.36 per 1000) (p = 0.02) with a relative risk of 2.75. No significant difference was found in maternal age between both groups (p = 0.67) and the rate of Down's syndrome was higher in infants of diabetic mothers when compared with infants of non-diabetic mothers of similar age. Down's syndrome should be added to the congenital malformations already known to occur more frequently in infants of diabetic mothers.

Adult↗