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Biomedical subjects

N Kvist

Publications and source records attributed to N Kvist.

10 recordsLinked to original sources
PubMed1989

Epidermal growth factor in urine after kidney transplantation in humans.

The urinary excretion of epidermal growth factor (EGF) was studied after kidney transplantation in 15 patients. At the final follow-up (between 38 and 173 days after transplantation) the 9 patients with a successful transplantation excreted EGF in the urine, but the concentration was low (0.13-1.1 nmol/l) compared to individuals with two kidneys (1.0-9.8 nmol/l). In all of the patients the urine creatinine increased prior to the increase in urine EGF. Patients who received cyclosporine A as immunosuppressive treatment excreted little or no EGF during the first month, while patients who received prednisone and azathioprine excreted EGF as early as four days after the transplantation. Our results together with earlier published data suggests that urinary EGF originates from the kidney.

Adult↗
PubMed1989

Malignancy in ulcerative colitis.

All patients with ulcerative colitis referred to Rigshospitalet, Copenhagen, from 1 April 1964 to 1 January 1983 (18 years and 9 months) were studied from time of referral until death, proctocolectomy, or end of the study (1983). There were 759 patients, 423 females (56%) and 336 males (44%). None was lost to follow-up study. Median time from onset of disease until death, proctocolectomy, or end of the study was 11 years (range, 0-54 years). Median age at onset was 28 years (range, 0-83) among the males and 28 years (range, 4-83) among the females. Pancolitis was present in 312 patients (41%), left-sided colitis in 212 (28%), and haemorrhagic proctitis in 235 (31%). Surgical treatment was performed in 299 patients (39%): proctocolectomy in 197 (26%), colectomy with occluded rectal stump in 72 (9%), and colectomy with ileorectal anastomosis in 30 (4%). Altogether, 49 patients developed cancer, 20 being intestinal and 29 extraintestinal cancer. Compared with the general population matched for age, sex, and calendar time, there was an excessive number with intestinal cancer in both sexes (p less than 0.05). In females the number with extraintestinal cancer was higher than in the general population (p less than 0.01), a finding that has not been reported elsewhere. We found a similar, significantly increased incidence of extraintestinal cancer in females with Crohn's disease in a previous report. We found no increased risk of colorectal cancer in patients with early onset of ulcerative colitis. For all age classes we found that the age of appearance of colorectal cancer followed the equation: age at colorectal cancer = 14 + age at onset of ulcerative colitis. We found no higher potential for development of colorectal cancer in patients with pancolitis. In our series the incidence of colorectal cancer in pancolitis and left-sided colitis was equal. The incidence in patients with haemorrhagic proctitis was zero.

Adolescent↗
PubMed1987

Secretion of goblet cell serine proteinase, ingobsin, is stimulated by vasoactive intestinal polypeptide and acetylcholine.

Ingobsin is localized to the intestinal goblet cells in the rat and in man. In the present study, we investigated the effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on the secretion of ingobsin from the proximal duodenum. Intravenous infusion of VIP or acetylcholine increased the concentration of ingobsin in duodenal secretion, while the concentration in the duodenum was unchanged. Simultaneous infusion of VIP and acetylcholine increased the concentration of ingobsin in duodenal secretion and decreased the concentration of ingobsin in the duodenum. This study demonstrates that secretion of ingobsin from the proximal duodenum is exocrine and can be stimulated by VIP and acetylcholine.

Acetylcholine↗
PubMed1986

Malignancy in Crohn's disease.

The incidence of cancer in Crohn's disease has been evaluated in 473 patients admitted to Rigshospitalet during the period 1 April 1964 to 1 January 1983. The patients' condition at the end of the survey, their survival, and the number and location of cancers were registered. During the survey period 23 cancers (4.9%) were found. Five were intestinal (1.1%) and were split evenly among the two sexes, whereas among 18 patients with extraintestinal cancers there was only 1 man. There was no increased risk of developing cancer inside the gastrointestinal tract compared with a background population matched for age, sex, and calendar time. Extraintestinal cancer in women was, however, significantly in excess.

Adolescent↗
PubMed1984

Hydrometrocolpos: current views on pathogenesis and management.

Hydrometrocolpos usually occurs in the neonatal period. The majority of cases are caused by vaginal occlusion by a transverse septum combined with cervical secretion. Although not well appreciated genital distension by urine may occur in some cases with a persistent urogenital sinus or cloaca. We report 3 cases of urinary and 8 cases of secretory hydrometrocolpos. The frequency of associated anomalies, especially in the urogenital tract, was high (9 of 11 patients), which was the most important factor in determining the morbidity and mortality. Of the patients 2 died, and 9 are alive and healthy, demonstrating that the prognosis of hydrometrocolpos is excellent. The diagnosis of hydrometrocolpos should no longer be difficult to determine. The most important step is a thorough vaginal examination, although modern imaging methods may be helpful. The aim of treatment is distal vaginal drainage, which can be achieved by a perineal procedure in most cases. Laparotomy is indicated only in cases of high vaginal atresia, which require a vaginal pull-through procedure.

Abnormalities, Multiple↗
PubMed1984

Clinical results of early and late operative correction of undescended testes.

Operative treatment of undescended testes was performed in 556 boys (695 testes). The histopathological changes in the testicular tissue were more severe in older patients. However, post-operative clinical results were found to be significantly better in boys treated immediately before puberty than in boys treated at an earlier age.

Adolescent↗
PubMed1983

Bullous acrodermatitis due to zinc deficiency during total parenteral nutrition: an ultrastructural study of the epidermal changes.

A 5 1/2-year-old girl with idiopathic intestinal pseudo-obstruction became severely depleted of zinc during total parenteral nutrition and developed a vesico-bullous rash on face, hands and feet such as is seen in acrodermatitis enteropathica. Light and electron microscopy of a bullous lesion on one foot revealed a pronounced extracellular edema with cyst and cleft formation in the deep part of the epidermis. A few acantholytic cells were seen. In the electron microscope degenerate keratinocytes showed multiple vacuoles in the dark cytoplasm and slender, finger-like protrusions. Desmosomes were few. The basal lamina was well-preserved forming deep invaginations, which may serve to distinguish the condition from other bullous diseases of the skin.

Acrodermatitis↗