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N L Aslanian

Publications and source records attributed to N L Aslanian.

At least 19 recordsLinked to original sources
PubMed1991

[The circadian rhythms of myoglobin concentrations in the blood serum in acute myocardial infarct and unstable stenocardia].

Patients with acute myocardial infarction and unstable angina pectoris do not demonstrate circadian time organization of myoglobin concentration rhythms. The predominance of ultraradian and infraradian neorhthmostasis is typical of such patients. Determination of myoglobin concentration rhythms in the given patients' group may be helpful in the measurement of the size of the focus of necrosis and prediction of the course and outcome of the diseases under consideration.

Angina, Unstable↗
PubMed1991

[Circadian rhythm of cortisol secretion in the acute stage of myocardial infarction].

Patients with macrofocal and transmural acute myocardial infarction (AMI) are reported to have statistically significant rhythms of cortisol secretion though there are cases of dysrhythmia. Circadian rhythms of cortisol secretion are typical for relatively light AMI course while a severe clinical run gives rise to dysrhythmia in the form of infradian neorhythmostasis or dysrhythmostasis of cortisol activity.

Adrenal Cortex↗
PubMed1990

[Changes in the rhythms of urinary sodium, potassium and chlorine excretion in patients with circulatory failure].

Measurements were made of the parameters (period, mesor, amplitude) of the rhythms of sodium, potassium and chlorine excretion with urine in patients with different stages of circulatory failure (CF). It has been shown that revelation of the status of neorhythmostasis is an early and sensitive criterion for estimating functions of electrolyte excretion by the kidneys in different CF stages. Dysrhythmostasis that increases depending on the stage of pathology attains maximum during stage IIB CF. In patients with stage IIB CF, there was an appreciable decrease of chlorine excretion mesor. This indicates that in solving the problem of deviation from normal, the parameters of the rhythm were not equally informative. The period turned out the most sensitive parameter of the rhythm. Determination of the time organization of functions and processes provides an undoubtedly more complete idea of the body on the whole.

Chlorine↗
PubMed1990

Chronopharmacology of strophanthin and inderal: an experimental study.

Chronopharmacological investigations were performed in 54 guinea pigs and 126 white mice to explore their tolerance to arrhythmogenic and lethal doses of strophanthin, and changes in sensitivity to threshold antiarrhythmic dose of inderal during 24 hours. The investigations were carried out at a 4-hour interval, i.e., six times in 24 hours. The data obtained were processed using the approximation method to determine sinusoid fluctuations with an initially given period (cosinor analysis) and with an unknown period (non-linear least-square method in combination with the method of gradual approximation) on an EC 1045 computer and a DZ 28 microcomputer. It was found that strophanthin toxicity in guinea pigs and white mice reaches a maximum in the late evening, night and early morning hours. The acrophases of circadian rhythms of chronotolerance to the threshold arrhythmogenic dose of strophanthin, and those of chronosensibility to inderal are virtually identical.

Animals↗
PubMed1989

[Rhythms of electrolyte excretion in healthy people].

The rhythms of urinary electrolyte excretion have been examined in normal subjects by following up every examinee for 72-120 hrs. Circadian rhythms have been detected in the predominant majority of the examinees. The mean values of other rhythm parameters (mesor, amplitude) have been established, that are suggested to be used as the reference values in the early diagnosis of abnormalities, with due consideration for the ecologic conditions and nutrition.

Adult↗
PubMed1989

[Changes in the parameters of the rhythms of the electrolyte-excreting function of the kidneys in women in relation to the seasons of the year].

The characteristics (period, mesor, amplitude) of the rhythms of urinary excretion of sodium, potassium, chlorine, calcium, magnesium, and phosphorus were examined in normal women during various seasons. The urine was collected for 5 days with 4-hour intervals. The rhythms were detected and their parameters established with the use of mathematical methods for the assessment of the tested curve fragments repetitions and by the least squares nonlinear method. The rhythms of renal urinary and electrolyte excretion were found very smooth, particularly so in the fall and winter. The circadian rhythms have been found the most stable during all the seasons. Examinations of individual electrolyte excretion have shown that Na and K excretion is more stable all the year round and therefore this parameter is the most informative for the detection of disorders in renal electrolyte excretion.

Activity Cycles↗
PubMed1989

[Circadian rhythms of mineral-excreting kidney function in healthy persons and their changes in ischemic heart disease].

Seventy normal persons and 100 patients with coronary disease were examined for circadian rhythms of urine and minerals excretion. The data obtained demonstrate that normal persons were characterized by circadian rhythms of urine and minerals excretion with a definite confidence interval of mesor and amplitude fluctuations. Angina pectoris of effort was marked by infradian rhythms of mineral excreting renal function. Monotherapy with beta-blockers or calcium antagonists given in courses entailed the recovery of the circadian rhythms of mineral-excreting renal function. Parameters of the rhythms of urine and minerals excretion in patients with angina pectoris of effort and rest noticeably differed from those in patients with angina pectoris of effort. In 30.7 percent of the persons, the use of the mathematic methods did not reveal any significant rhythms. The circadian range was found to predominate among the significant rhythms. Antianginal treatment did not produce any appreciable changes.

Adrenergic beta-Antagonists↗
PubMed1986

[Chronobiological approach to the diagnosis and therapy of cardiovascular diseases].

Some aspects of chronodiagnosis and chronotherapy of cardiovascular diseases were described. To reveal circadian cycles each examined person was observed for 3-5 days, the indices studied being measured every 4 h. The evaluation of a rhythm period was done using the dispersion analysis for the detection of non-sinusiodal rhythms and the approximation method for the detection of sinusoidal rhythms with a preset period (the cosignor analysis) and an unknown period (the least square method combined with the iteration method). Opportunities for the detection of changes or disorders of the time structure of examined function and approaches to chronotherapy were studied on clinical material.

Animals↗
PubMed1984

Comparative analysis of circadian rhythms of certain functional indicators of the cardiovascular system in healthy subjects and in patients with ischaemic heart disease.

The circadian rhythm of certain functional indicators of the cardiovascular system was investigated in 141 patients with ischaemic heart disease (IHD), of whom 65 had post-infarction cardiosclerosis and in 26 healthy subjects. The obtained data were processed by an ES-1020 computer according to a special "Cosinor" programme. Specific circadian rhythm was determined of certain haemodynamic indicators, sinus node excitability, impulse conduction, myocardial supply (according to ECG data) and of the blood clotting system. In healthy subjects, the coincidence of the acrophases of circadian rhythms of functional indicators of the cardiovascular system was found; these indicators reached their maximum level during the day and in the evening. In patients with IHD (with prior myocardial infarction as well as without), there were found shifts in the circadian rhythm of bioelectrical processes in the myocardium, with the maximum values shifted to the night and morning hours. These shifts are a consequence of changes in myocardial nutrition and of worsened coronary flow during the day and in the early evening hours, when the patients exhibit also a tendency towards increased activity of the blood clotting system, as well as fibrinolysis depression.

Blood Coagulation↗
PubMed1981

[Blood electrolyte homeostatic disorder in hypertensive patients and their relatives].

The results of study of the blood electrolyte homeostasis in patients with hypertensive disease and in their close relatives are discussed. It was established that the blood electrolyte homeostasis in healthy relatives of probands, patients with hypertensive disease, was changed as compared to that in healthy individuals of the same age in whose families there were no members with elevated arterial pressure.

Adult↗
PubMed1980

[Disorder of circadian lipid rhythms in ischemic heart disease].

Thirty-six healthy males and 157 males with ischemic heart disease were examined. Healthy males had statistically significant changes in the daily rhythm of cholesterol, triglycerides, glucose, and total blood serum lipids, while the rhythms of nonesterified fatty acids, total phospholipids, and overall content of beta- and pre-beta-lipoproteins were statistically insignificant. Patients with ischemic heart disease had statistically significant rhythms of cholesterol, triglycerides, total lipids, and total phospholipids, while the daily rhythms of nonesterified fatty acids, glucose and the overall content of beta- and pre-beta-lipoproteins in blood serum were statistically insignificant. Desynchronization of the acrophase of the daily rhythm of the overall content of beta-and pre-beta-lipoproteins as compared to the findings in healthy individuals was encountered.

Adult↗
PubMed1980

[Change in the circadian rhythms of the ECG T-wave value in ischemic heart disease].

Rhythmological study of the T wave on the ECG was conducted for 24 hours in 25 healthy individuals and 141 patients with ischemic heart disease. A daily rhythm of changes in the blood supply to the myocardium was revealed. Its maximum values were recorded during the day in healthy individuals and during the night and in the morning in sick individuals, i.e. the rhythm in patients was distorted and desynchronized. Consequently, atherosclerosis of the coronary arteries as an organic disease has an effect on the natural daily rhythm of the blood supply to the myocardium.

Adult↗