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N L Boĭko

Publications and source records attributed to N L Boĭko.

4 recordsLinked to original sources
PubMedDate not supplied

[Medico-biological evaluation of sodium salt of nitrofurylacrylic acid as a food additive].

Nitrofurylacrylic acid sodium salt is a substance of moderate toxicity. Its LD50 for male rats after oral administration comprises 1220 mg/kg, for female rats--1400 mg/kg. The minimal toxic dose, in case of long-term administration comprises 14 mg/kg. At the level of doses from 0.04 to 4.0 mg/kg no mutagenic effect was detected. Oral and subcutaneous administration of minimal tolerance doses of the agent induced formation of malignant neoplasms developing, predominantly, from the epithelial tissue, with localization depending on the route of the agent administration. A conclusion has been made on impossibility of using this substance as a food additive.

Acrylates↗
PubMedDate not supplied

[Experimental study of the possible use of sodium dehydroacetate as a food additive].

The results are presented of toxico-hygienic investigations of dehydroacetic acid sodium salt (DHASS) proposed as a food additive. The compound toxicity values have been assessed, and late results of the preservative influence on the body of experimental animals after its oral intake have been studied. An approximate value of daily intake (AVDI) of the compound has been calculated. It has been shown that DHASS cannot be recommended as a food additive because its technologically effective concentrations are significantly higher than AVDI.

Animals↗