N L Kelty | PubMed Health

PubMed1998

Dual-isotope protocol for indium-111 capromab pendetide monoclonal antibody imaging.

OBJECTIVE: A dual-isotope imaging protocol using 99mTc-labeled red blood cells with 111In capromab pendetide monoclonal antibody imaging for detective and localizing nodal metastasis in prostate cancer is described. METHODS: This protocol involves a single SPECT acquisition that is less time consuming and more comfortable for the patient than the currently recommended method, which requires two separate SPECT acquisitions performed on different days. RESULTS: Forty patients were studied with the dual-isotope protocol. Preliminary data suggest increased accuracy compared with the single-isotope technique. CONCLUSION: The dual-isotope technique assures the precise image registration needed for accurate comparison of blood pool and pelvic lymph node activity that is required for confident and accurate image interpretation.

Antibodies, Monoclonal↗

PubMed1997

Technical considerations for optimal orthopedic imaging.

Over the past 25 years bone scintigraphy has played an essential role in most Nuclear Medicine departments, accounting for 25% to 60% of the patient volumes. No longer is every bone scan ordered as part of a metastatic workup. Today radionuclide bone imaging (RNBI) is included in most orthopedic diagnostic pathways. It is necessary to optimize the bone scan procedure to be sensitive, to carefully localize abnormal uptake for diagnosis, to correlate the bone scans, plain radiographs, computed tomographic (CT) scans, and magnetic resonance (MR) scans that accompany the patient, and to be precise in reporting a final impression. This can be done through meticulous attention to the image acquisition so that it encompasses not only equipment specifications and acquisition parameters, but also patient history, preparation, imaging protocols, positioning, and image correlation. The importance of these considerations, the rationale to explain them, and suggested guidelines for their implementation will be discussed in this article.

Bone Diseases↗