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Biomedical subjects

N L Rosenbaum

Publications and source records attributed to N L Rosenbaum.

8 recordsLinked to original sources
PubMed1988

The use of flumazenil as an antagonist to midazolam in intravenous sedation for dental procedures.

The efficacy of flumazenil was tested in a double-blind placebo controlled study of 40 patients undergoing dental procedures. Flumazenil recipients were less sedated at 5 and 30 min post-operatively (P less than 0.001), were better oriented at 5 min (P less than 0.001) and 30 min (P less than 0.01) and were more co-operative at 5 min (P less than 0.001) and 30 min (P less than 0.005). None of the patients in either the placebo or flumazenil groups could remember operative events. The dental surgeon felt that flumazenil made recovery in the supine position unnecessary and made post-operative monitoring easier. Flumazenil is a drug that should be included in the armamentarium of any emergency drug kit when benzodiazepines are used i.v.

Adolescent↗
PubMed1986

Local complications following intravenous benzodiazepines in the dorsum of the hand. A comparison between midazolam and Diazemuls in sedation for dentistry.

Two hundred patients requiring sedation for minor oral surgery were randomly allocated to receive either midazolam or diazepam as Diazemuls intravenously through a 23-gauge indwelling needle in the dorsum of the hand. The site of injection was inspected at 7 days and 14 days post injection and assessed for pain, tenderness, redness, induration, painless thrombosis, and thrombophlebitis. The mean dose administered was 0.119 mg/kg of midazolam and 0.298 mg/kg of Diazemuls. At 7 days there was no significant difference in venous complications. At the 14 day follow up, the midazolam group had a significantly greater incidence of tenderness and redness (p less than 0.001 and p less than 0.05 respectively using Chi squared test). The incidence of thrombophlebitis in the midazolam group was 2% at 7 days and 1% at 14 days, the corresponding figures in those given Diazemuls being none and 1% respectively. We conclude that the dorsum of the hand is a satisfactory site of injection for administration of these drugs. The higher incidence of minor complications at 14 days following midazolam was offset by its more reliable amnesic properties.

Adult↗