Biomedical subjects

N L Rush

Publications and source records attributed to N L Rush.

3 recordsLinked to original sources

PubMed1984

Altered auditory brainstem evoked responses in the ferret model for Reye's syndrome.

The effects of influenza B, aspirin and hyperammonemia on the functional integrity of the cochlea were examined using the ferret model for Reye's syndrome. Auditory brainstem evoked responses (ABR) were recorded from treated ferrets and compared to those recorded from controls. Delayed latencies of all waves, as well as increased I-IV Interwave latencies were observed in recordings from treated ferrets. Importantly, the latencies of Wave I, nerve generator potential from the eighth nerve, and Wave IV, response potential from the brainstem nuclei, increased on Days 3 and 5 of the study. However, recorded ABR from treated ferrets on Day 10 showed that while the latencies of Wave IV were approximate to those of controls, Wave I remained delayed. These results suggest that systemic effects of influenza B, aspirin and hyperammonemia may lead acutely to both peripheral and central auditory dysfunction, and that the functional integrity of the central auditory system may recover more quickly than that of the peripheral system. Furthermore, these results suggest that such effects may lead to acute transient hearing impairment in patients with Reye's syndrome.

Ammonia↗

PubMed1984

Fentanyl anesthesia and human brain-stem auditory evoked potentials.

The effect of incremental doses of fentanyl on brain-stem auditory evoked potentials (BAEPs) was studied in 10 patients scheduled for elective surgery. Seven sets of BAEPs were recorded in each patient starting the day before surgery, after premedication and after 10 micrograms/kg increments of fentanyl up to 50 micrograms/kg. No significant effect on either absolute or interpeak latencies of wave I, III, and V of evoked potentials was observed.

Adult↗

PubMedDate not supplied

Effects of influenza infection, aspirin, and an arginine-deficient diet on the inner ear in Reye's syndrome.

The individual effects of an influenza B viral infection, aspirin, and an arginine-deficient diet on the inner ear were assessed in the ferret model for Reye's syndrome using both functional and morphological parameters. Auditory brainstem evoked responses recorded from inoculated ferrets revealed threshold elevations and increased latencies during the first 72 hours, but approximated those of control animals by 96 hours. Although there was a mild distention of Reissner's membrane, no pronounced structural alterations in sensory or supporting cells were observed in cochleas from inoculated ferrets. The administration of aspirin appeared to alter neither the functional nor the structural integrity of the cochlea. The presentation of an arginine-deficient diet, creating a hyperammonemic condition, led to both altered auditory evoked responses and vacuolization of cochlear tissues after treated animals had undergone seizures and coma. These data demonstrated that both influenza B and the arginine-deficient diet individually affected the hearing of treated animals. The individual agents did not alter the cochlea as severely as when they were presented in combination. These results suggest that hearing impairment in patients with Reye's syndrome may be a result of potentiation of certain metabolic-altering agents.

Animals↗