Nitric oxide and cerebral ischemia.
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Amino Acid Oxidoreductases↗
Biomedical subjects
N Lakhmeche
Publications and source records attributed to N Lakhmeche.
Nitric oxide: an endogenous anticonvulsant substance.
In the present study, we examine the involvement of the L-arginine-nitric oxide pathway in seizure activity termination. Convulsions were induced reproducibly by intracerebroventricular administration of N-methyl-D-aspartate to conscious mice. The duration of the seizure activity was increased by inhibition of the NO-pathway or by intracerebroventricular injection of methylene blue, an inhibitor of guanylate cyclase activity. This increased duration in seizure activity was reversed by co-administration of L-arginine or by intracerebroventricular injection of guanosine 3':5' cyclic monophosphate (cGMP). These results suggest that nitric oxide produced in response to NMDA receptor activation leads to an increase in cGMP which induces the seizure activity termination.
Amino Acid Oxidoreductases↗