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Biomedical subjects

N Lazaridis

Publications and source records attributed to N Lazaridis.

At least 19 recordsLinked to original sources
PubMed2004

Adjuvant chemotherapy in colorectal cancer.

UNLABELLED: Our aim was to study the three-fold response to treatment, survival rates and toxicity. MATERIALS AND METHODS: We review 76 patients (median age 66.2 years) affected with the disease. All received adjuvant chemotherapy, while 13 with rectal cancer were subjected to radiation too. Patients were staged after Duke's classification. RESULTS: Recurrence was noted in 15 patients, 3 at stage B and 12 at stage C; median recurrence-free interval was 18.9 months. Patients without relapse had a median disease-free period of 35.9 months. Median overall survival was 35.21 months. The 5-year survival mark have surpassed 14 patients (3 with recurrent disease): 8 at stage B and 6 at stage C. Ten have died; median survival in these patients was 30.5 months. No patients suffered from severe bone marrow toxicity; mucositis and diarrhoea grade III/IV was noted in 10 patients.

Adult↗
PubMed2003

Double mandibular osteotomy with coronoidectomy for tumours in the parapharyngeal space.

Removal of deep-lobe parotid tumours from the parapharyngeal space is often difficult because of limited surgical access and the critical vascular and neurologic structures nearby. Mandibulotomy, when necessary, is useful for improving wider visibility and control of the vascular bundle and facial nerve, but may cause damage to the inferior dental and lingual nerves. The double mandibular osteotomy with coronoidectomy gives excellent access and avoids damage to these nerves.

Adenoma, Pleomorphic↗
PubMed2003

Treatment of squamous cell carcinoma of the anterior faucial pillar-retromolar trigone.

Cancer of the anterior faucial pillar-retromolar trigone is an uncommon head and neck tumor, which has historically been shown to be associated with poor prognosis. In this retrospective study, we reviewed our experience with primary surgery followed by postoperative radiation therapy in order to determine the impact of our treatment protocols on patients' outcome. Between January 1994 and December 1998, 31 patients with histologically proven squamous cell carcinoma (SCC) of the anterior faucial pillar-retromolar trigone were treated in our department. Surgical excision of the primary lesion and ipsilateral neck dissection were performed in all patients. Reconstruction was accomplished using masseter muscle flap or tongue flap. Postoperatively, most patients (90%) received radiation therapy (51-58 Gy) to the primary side and neck. Adjuvant chemotherapy was offered if histologic signs of aggressive behavior were identified. Four out of 31 patients were initially seen at stage I or II and 27 patients at stage III or IV of the disease. Metastatic disease was demonstrated in 78% of ipsilateral neck nodes. Occult metastases were found in 64% of clinically N0 necks. The 3-year loco-regional recurrence rates were 44.8%. SCC of retromolar trigone is considered as an aggressive and insidious tumor. The reconstruction of the deficit of the anterior faucial pillar-retromolar area with masseter muscle flap is a reliable, safe and absolutely functional method.

Adult↗
PubMed1998

Correction of the protruding ear with a modified anterior scoring technique.

PURPOSE: This article describes a modified anterior scoring technique to provide natural-looking results after correction of the protruding ear. The modified technique is described, and its advantages are compared with the conventional anterior scoring technique and with the other two basic techniques (Converse and Mustardé). PATIENTS AND METHODS: The modified technique was used to treat eight patients. In these cases, the use of transfixion mattress sutures placed through the perichondrium was very helpful in achieving a smooth curvature. RESULTS: Results up to 1 year showed no alteration in form when compared with the short-time results. CONCLUSION: The conventional anterior scoring technique for otoplasty is one of the most useful and reliable techniques, applicable in all cases of prominent ears. However, in some cases, it is difficult to control the cartilage bending completely. By using three adjusting mattress sutures (4-0 vicryl) through the perichondrium on the posterior side, combined with shallower scoring incisions, it is possible to create symmetry with the opposite ear and prevent "telephone ear" complication.

Adolescent↗
PubMed1998

The inferiorly and superiorly based nasolabial flap for the reconstruction of moderate-sized oronasal defects.

PURPOSE: The usefulness of the inferiorly or superiorly based nasolabial flap for the unilateral or bilateral reconstruction of local extraoral and intraoral defects was evaluated. PATIENTS AND METHODS: In a 10-year period, 22 flaps were used in 15 patients to cover defects of the floor of the mouth, nose, and chin. Fourteen bilateral and two unilateral flaps were inferiorly based, and six unilateral flaps were superiorly based. RESULTS: Dehiscence, which occurred in one case, and obstructive sialadenitis which occurred in another, were the main complications. CONCLUSION: The nasolabial flap is a useful procedure for the reconstruction of moderate-sized oronasal defects because of its simple elevation, proximity to the defect, and versatility.

Adult↗
PubMed1998

Sublingual hypoglossal neurilemmoma. Case report.

Neurilemmomas of the peripheral segment of the hypoglossal nerve are extremely uncommon neoplasms. A rare case of hypoglossal neurilemmoma located in the sublingual space is reported and the differential diagnosis of sublingual mass lesions is discussed.

Cranial Nerve Neoplasms↗
PubMed1998

Dermal psoriasis involving an oral split-skin graft. Case report.

Psoriasis is a chronic inflammatory skin disease which very rarely affects the oral cavity. It has many forms of expression on cutaneous and mucosal surfaces. This paper describes an unusual case of psoriasis with oral involvement affecting the skin graft used to reconstruct an oral mucosal defect. Diagnosis was based on clinical and microscopic findings and confirmed by the concurrent cutaneous disease.

Adult↗
PubMed1998

Primary malignant melanoma of the oral cavity. Report of an unusual case.

Primary malignant melanoma is only rarely found in the oral cavity (estimated at between 0.2 and 8 per cent of all melanomas) and occurs approximately four times more frequently in the oral mucosa of the upper jaw, usually on the palate or alveolar gingivae. A case is reported of a malignant melanoma in the mouth of a 74 year old male, which was originally diagnosed as reactive denture hyperplasia caused by a ill-fitting upper denture. Correction of the denture fault failed to stop the growth of the mass, which was therefore removed surgically. Histological examination revealed a melanin-producing tumour. A partial maxillectomy was performed and there was no evidence of recurrence over a three year follow-up period.

Aged↗
PubMed1991

Primary tuberculosis of the oral cavity.

Two cases of primary tuberculosis of the mouth are reported. Painless ulceration of long duration and enlargement of the regional lymph nodes that did not respond to conservative and antibiotic therapy were the main manifestations of the disease in both cases. In the first case the tubercle ulcer was located in the lower buccogingival sulcus of a 17-year-old girl. In the second case the lesion occurred as a chronic periodontal inflammation around the gingiva of the left lower second molar tooth. When the tooth was extracted, a painless ulceration appeared around the socket, which was filled by granulation tissue. Histopathologic examination; bacteriologic, serologic, and blood tests; and chest x-ray film confirmed the diagnosis. Predisposing factors that might favor primary inoculation of tubercle bacilli into oral mucosa are also discussed. Finally we emphasize that in such cases it is essential to attempt to locate a possible primary site elsewhere in the body before oral tuberculosis is considered the primary disease.

Adolescent↗
PubMed1989

[Temporalis muscle flaps for coverage of intraoral defects following radical surgery for oral carcinoma].

The use of the temporalis muscle flap for reconstruction of intraoral defects is not a new procedure. In the oral and maxillofacial surgery clinic of Thessaloniki we have been using this muscular flap for the last three years. The results from the application of this method showed that the use of the temporalis muscle flap is preferable in comparison with the forehead skin flap which we were using in the past for the reconstruction of intra-oral defects left behind after excising large malignancies of the mouth and jaws.

Aged↗
PubMed1986

The internal carotid artery in the surgery of extensive oral cancer.

The selective sacrifice of the carotid arteries during extensive neck operative procedures, or their compulsory ligation after an exposure or hemorrhage postoperatively, are among the most serious problems in head and neck surgery. As the highest percentage of disastrous results, following ligation of the carotid vessels, occurs in those patients to whom ligation has been performed at a time when the blood pressure was low, due to preceding hemorrhage or shock, the selective ligation (or excision) of these vessels is not such a dangerous procedure. In 6 cases of selective ligation of carotid arteries, there was only one non-permanent, partial hemiplegia.

Adult↗