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N Leelawongs

Publications and source records attributed to N Leelawongs.

3 recordsLinked to original sources
PubMed1990

Ocular findings in oculodermal melanocytosis.

We examined 194 patients with oculodermal melanocytosis. Dermal involvement alone was present in 67 (34.5%) patients, while 12 (6.2%) had only ocular involvement. The remaining 115 (59.3%) patients had both ocular and dermal pigmentation. Dermal hyperpigmentation in the combined distribution of the ophthalmic and maxillary divisions of the trigeminal nerve and hyperpigmentation of the nasal or buccal mucosa were closely associated with ocular involvement. Ocular hyperpigmentation most commonly involved the episclera. Associated ocular findings included elevated intraocular pressure with or without glaucoma (10.3%), uveitis (2.6%), cataract (1%), asymmetric cupping of the optic nerve head unassociated with glaucoma (9.8%), and orbital melanoma (0.5%). The most serious complication of oculodermal melanocytosis is malignant transformation, while glaucoma appears to be the more common one. Patients with oculodermal melanocytosis and ocular hyperpigmentation should be followed up at regular intervals for the development of either of these complications.

Adolescent↗
PubMed1990

Glaucoma in oculodermal melanocytosis.

Oculodermal melanocytosis (ODM) is a developmental disorder of the embryonic neural crest involving virtually all of the structures of the eye derived from this tissue. The authors examined 194 previously unreported Thai patients with ODM. Elevated intraocular pressures (IOPs) developed in the ipsilateral eye of 15 patients at initial examination and in 5 others during follow-up, for a total of 10.3% of the patients. Three patients had congenital or late congenital glaucoma, 14 had ocular hypertension or open-angle glaucoma, and 3 had acute angle-closure glaucoma. Five of the patients with open angles had acute pressure rises accompanied by anterior uveitis. Melanocytic hyperpigmentation of the anterior chamber angle was extensive in all patients except those with acute angle-closure glaucoma. There was no consistent correlation between the extent or density of angle pigmentation and the development of elevated IOP. A larger cup-to-disc ratio in the involved eye, presumably congenital, was present in an additional 19 patients. Glaucoma is common in eyes with ODM and may develop at any age. Patients with ODM and initially normal IOP should be examined at regular intervals. Patients with open angles and acutely elevated IOP should be examined carefully for signs of anterior uveitis and treated medically.

Adolescent↗