Biomedical subjects

N Lempert

Publications and source records attributed to N Lempert.

54 records · Page 3Linked to original sources

PubMed1981

Phenytoin, methylprednisolone sodium succinate and graft survival.

A laboratory study was undertaken to explore the possible interference of phenytoin with the immunosuppressive effect of methylprednisolone sodium succinate on skin graft survival in mice. Full thickness skin allografts were performed on five groups of 10 mice. Each group received various combinations of phenytoin and/or methylprednisolone sodium succinate or no treatment at all (control). In vitro stimulation of lymphocytes from these mice with phytohemagglutinin was carried out to corroborate the immune status of the recipients. All mice demonstrated prolonged graft survival as compared to the control group regardless of what agents were used. Our results indicate that the concomitant administration of phenytoin and methylprednisolone sodium succinate does not accelerate skin homograft rejection in the murine model.

Animals↗

PubMed1979

Vascular access for cancer chemotherapy.

Eleven bovine heterografts were utilized in the repetitive administration of chemotherapy in 10 patients with insufficient vascular access. Six grafts remained patent until the time of death and five grafts clotted from 71 to 1110 days postoperatively. Three patients are alive and well. All grafts were initially patent and no wound infections resulted. The bovine heterograft appears to be a useful adjunct for securing vascular access for patients requiring cancer chemotherapy.

Animals↗

PubMed1978

Chronic granulocytic leukemia following successful renal transplantation.

The use of immunosuppressive therapy has markedly increased over the past several years, and concomitant with its use has been an increased frequency of associated neoplasia. The patient presented is a 22-year-old white male who, following two renal transplants and prolonged immunosuppressive therapy with azathioprine and methylprednisolone, developed chronic granulocytic leukemia. Chromosome karyotyping demonstrated the somewhat unusual development of a Philadelphia chromosome with translocation to the No. 7 of the C group. A review of transplantation centers revealed that five cases of chronic granulocytic leukemia have occurred in a population of 25,000 renal transplant patients, a 5-fold increased incidence over the general population. Possible etiologies that may be responsible for the development of chronic granulocytic leukemia in patients on immunosuppressive therapy are discussed. It is our hope that by the introduction of these reports of chronic granulocytic leukemia into the medical literature, the need for caution in the use of immunosuppressive drugs in nonmalignant disease will again be emphasized.

Adult↗

PubMed1978