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N M Anichkov

Publications and source records attributed to N M Anichkov.

52 records · Page 3Linked to original sources
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[About morphology and classification of tumor-like and malignant prostatic lesions].

This review contains updated information on benign prostatic hyperplasia, basal cell hyperplasia, atypical adenomatous hyperplasia, prostatic intraepithelial neoplasia, different forms of carcinoma and rare prostatic neoplasms. The literature and the authors' clinico-morphological investigation of 687 patients are analysed. The diagnostic significance of some morphological markers (mitotic activity, the presence of crystalloids, amyloid bodies, the activity of endocrine-paracrine cells, etc) as well as the significance of PSA-test in various types of lesion are considered.

Humans↗
PubMedDate not supplied

[Endometrial pathomorphology during hormonal actions].

The article reviews updated information on endometrial morphology in normal 28-day menstrual cycle, endometrial changes under the effect of sex hormones present in different contraceptive and anticancer drugs.

Antineoplastic Agents, Hormonal↗
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[Spitz nevus (juvenile nevus) of the penile skin].

Compound spindle cell and epithelioid cell nevus (Spitz nevus) at the anterior surface of the penile skin in a 31-year-old patient is described. The histological structure of the tumor is discussed in terms of differential diagnosis.

Adult↗
PubMedDate not supplied

[The 300-th anniversary of pathologic anatomy in Saint-Petersburg].

The paper is an overview that covers a long historical period that was marked by the first autopsies (under Peter the First), the development of large research schools, the teaching of students, the training of pathologists, the origin of experimental pathology, the appearance of outstanding discoverers (N.N. Anichkow, A.A. Maximov, L.V. Sobolev), and the foundation of the Research Society of Pathologists.

Anatomy↗
PubMedDate not supplied

[Liver hemosiderosis in chronic hepatitis].

Liver hemosiderosis (LH) was studied in chronic hepatitis (CH) B and C and CH of other and alcoholic (AL) etiology. LH was present in 122 patients (a study group) and was absent in 188 patients (a comparison group). LH is considered to be a marker of organ iron overload. The total incidence of LH was 39.4 +/- 2.7%, including 33.3 +/- 5.6% in LH-B, 49.3 +/- 5.8% in LH-C, and 48.7 +/- 8.0% in AL. The association with LH was characterized by a longer duration of the disease, by a higher activity and degree of hepatic cirrhosis. The efficiency of reaferon therapy was lower in hepatitis B and C in the presence of LH. These forms of the disease are considered to be secondary hemosiderosis.

Hemosiderin↗
PubMedDate not supplied

[Endocrine cells of rectal epithelium in health, in nonspecific ulcerative colitis and irritable colon syndrome in the treatment with prednisolone and salofalk and in the absence of treatment].

The arrangement and ultrastructure of rectal intraepithelial endocrine cells in health, in nonspecific ulcerative colitis (NSUC) and in irritable colon syndrome (ICS) were studied with light and electron microscopy. An increase of the amount of these cells was registered at the initial stages of inflammation, whereas chronic and destructive states were accompanied by the cells decrease. A decrease of endocrine cells number in (NSUC) was pronounced more than in ICS. Compared to prednisolone, the treatment with salofalk produced a more positive effect on endocrine cells reproduction within the rectal lining. The endocrine cells ultrastructural changes found by the authors in ulcerative colitis and irritable colon showed similarity to those in other colon diseases.

Adult↗
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[Celiac disease in adults: histological and morphometric data].

A morphologic and morphometric study of duodenal mucosal biopsies obtained from 90 patients suffering of celiac sprue was done. The results were compared with clinical, serological features as well as with information on inheritance. The diagnosis of celiac sprue was made when there was a combination of both specific clinical and serological signs with chronic atrophic mucosal changes in the duodenum correlating with morphometrical data. It was concluded that the lack of one of the mentioned parameters makes the diagnosis invalid and the patient needs further observation.

Adolescent↗
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[Combination of uterine adenomyosis with leiomyoma].

A morphological analysis of 50 cases of adenomyosis (AM) and 150 cases of AM combination with leiomyoma (LM) with regard to their morphofunctional and histotopographical interrelations was performed. The asynchronous character and mosaicism of estrogen/progesteron receptors expression in the gland epithelium and AM stromal cells of one patient was established immunohistochemically. This probably determines uneffective hormonal therapy of AM patients. A correlation of steroid hormone receptor expression in AM foci and in leiomyocytes of perifocal myometrium hyperplasia was also found. This indicates a common pathogenic mechanism of AM and LM. An increase of the size of the uterus depended on the degree of perifocal leiomyocyte hyperplasia with microscopical nodule formation in LM.

Adult↗
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[Mast cells in photolesion of the skin and basal cell cancer associated with it].

Morphofunctional features of skin mast cells located in the areas subjected to chronic UV-radiation and in the associated basal cell carcinoma with photoinjure have been studied. Various immunohistochemical methods (chromogranin A, CDla, HLA-DR, CD35, Ki67, P53, Bcl-2, Mcl-1, involucrine) were used. It is found that chronic UV-damage leads to mast cell hyperplasia as well as activation of their synthetic, absorption and secretory functions. It is suggested that mast cell hyperplasia and increase of mast cells neuroendocrine activity provide a risk of basal cell carcinoma development.

Adult↗
PubMedDate not supplied

[Anaplastic thyroid carcinoma with osteoclast-like giant cells].

Rapidly growing thyroid tumour in a female of 70 is reported. Histologically, the structures of three types were distinguished: follicular adenoma, follicular-solid form of the follicular adenoma and poorly differentiated tumour with presence of osteoclast-like cells. The latter were shown to contain an immunoreactive thyroglobulin. The origin of this giant cells in the thyroid tumour is discussed.

Adenoma↗