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Biomedical subjects

N M Constantinescu

Publications and source records attributed to N M Constantinescu.

At least 19 recordsLinked to original sources
PubMed1982

Experimental studies in transient myocardial ischaemia.

The biology of the myocardium was studied under experimental conditions similar to angina pectoris. In some dogs the myocardium was adapted to ischaemia by progressive coronary occlusion of 1-5 min followed by restoration of circulation during 5 min. In other dogs adaption was followed by 20 to 35 min ischaemia. The animals were sacrificed immediately or after 2-10 days. Transient ischaemia produced less severe alterations then abrupt coronary obstruction. Adaptation followed by 20 and 35 min ischaemia induced foci that undergo cytolysis and scarring of maximum intensity on the 8th day. Activity of enzymes in the mitochondrial suspension, especially of cytochromoxidase, decreases and lysosomal hydrolases increase with focal necroses.

Angina Pectoris↗
PubMedDate not supplied

Experimental investigations in acute myocardial ischaemia. Note II. Studies concerning morphophysiologie alterations of the ischaemic myocardium under vascularization conditions.

The biology of the myocardial fiber was studied under experimental conditions similar to angina and the premonitory syndrome of myocardial infarction. The morphophysiologic data obtained particularly concerning the mitochondria demonstrated that affection of the myocardium by progressive ischaemia induced less severe lesions than the abrupt onset of ischaemia, also lowering the frequency of ventricular fibrillations.

Animals↗
PubMedDate not supplied

[Primary exertion thrombophlebitis of the upper extremities: clinical and therapeutic aspects].

The authors present 4 cases of "effort" thrombophlebitis of the upper limb that were diagnosed both clinically and thrombophlebographically, and in whom classical therapy was applied: total rest, anticoagulants, elevation of the limb. All the cases had sequels of variable intensity, and in 2 of the patients Roos' transaxillary route was used which revealed a double anterior scalenus muscle insertion, and compressive fibro-sclerous tissue. The pathogeny of the affection makes mandatory the removal of extrinsic or intrinsic factors which may generate a new thrombosis or vascular and neurologic sequels.

Adult↗
PubMedDate not supplied

[Nongynecologic abdominal emergencies during pregnancy].

The paper reports on the authors' experience in the surgical emergency of a special category of patients: pregnant women with acute affections requiring surgery. The clinical aspects, sometimes deceptive, diagnosis difficulties and tactile and technical surgical attitudes are presented in detail.

Abdomen, Acute↗
PubMedDate not supplied

[Neurolysis of the posterior tibial nerve in the tarsal canal--a new therapeutic approach in chronic painless plantar ulcers].

The paper reports on 14 cases of perforating plantar disease of whom 11 belong to the so-called nonpainful chronic plantar ulceration by compression of the posterior tibial nerve in the tarsal canal. The authors show clinically, neuroelectrically and by neurography with lipiodol that in the case of a diabetic or alcoholic polyneuropathy, the posterior tibial nerve is more vulnerable to the compression existing in the tarsal canal due to the development of a fibrous sclerotic tissue. Exo-endoneurolysis of the posterior tibial nerve associated with a posterior tibial periarterial sympathectomy permitted healing in 7 ulcerations, 2 diminutions of the ulceration dimensions, and only 2 remissions. The four cases of unfavourable results were in patients with old lesions who continued alcohol consumption.

Adult↗
PubMedDate not supplied

[Intra-anesthetic hypothermia].

Oesophageal temperature was recorded after induction of anesthesia, and further, at one, two and three hours. Temperature in the operation hall was continuously monitored. In relation to the temperature in the operating hall the effects on the patient were of three kinds: 1. operating halls with low temperatures (under 21 degrees C) where all the patients become hypothermic; 2. operating halls with an intermediate temperature (21-24 degrees C), where 67% of the patients remain normothermic; 3. operating halls with high temperatures (above 24 degrees C) where all the patients remain normothermic, although these temperatures are uncomfortable for the medical personnel, and increase the septic risk of the patient. When the oesophageal temperature of the patients falls by 0.5 degrees C chills will occur in 40% of the patients. Thermal falls of less than 0.5 degrees C will also determine chills but in only 10.5% of the cases. Immediate postanesthesia chills are also recorded in normothermic patients, but there is a direct relationship between the temperature in the operating hall, the degree of hypothermia and the frequency of chills, while the site of the surgery or the duration of the operation have but an unsignificant influence on intra-anesthetic temperature.

Adult↗