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Biomedical subjects

N M Girdler

Publications and source records attributed to N M Girdler.

At least 19 recordsLinked to original sources
PubMed1997

The role of mandibular condylar cartilage in articular cartilage repair.

The articular hyaline cartilage of synovial joints has a very limited capacity for repair after injury. In contrast, the mandibular condylar cartilage of the temporomandibular joint possesses as intrinsic potential for regeneration. This study aimed to test the hypothesis that cultured allografts of mandibular condylar cartilage could be used to promote biological repair of injured orthotopic joint surfaces. Using a primate animal model, cultures of mandibular condylar cartilage cells were grafted into surgically created defects in a recipient hyaline cartilage joint surface. Articular wound healing was assessed macroscopically and histologically over a postoperative period of 52 weeks. Mandibular condylar cartilage cells scheduled for allogenous transplantation were initially characterised in vitro. Expansion of primary colonies in organ culture provided the allogenic cellular material for in vivo grafting. Grafting of osteochondral articular wounds with 5-week cultures of mandibular cartilage cells led to wound regeneration with complete reconstitution of articular surface continuity by 52 weeks. There was novel synthesis of cartilage collagens and sulphated glycosaminoglycans within the repair tissue and no evidence of immunological rejection. Healing of grafted defects was thought to occur by a combination of donor cell proliferation and ingress of host mesenchymal cells. In contrast, grafted control wounds underwent largely fibrous repair with incomplete articular regeneration. In conclusion, transplanted allografts of cultured mandibular condylar cartilage appeared to have the ability, in this primate model, to promote cartilaginous repair and regeneration of orthotopic articular wounds.

Animals↗
PubMed1995

The effect of epidermal growth factor mouthwash on cytotoxic-induced oral ulceration. A phase I clinical trial.

A double-blind clinical trial was performed to study the effect of epidermal growth factor (EGF) mouthwash on the healing and recurrence of oral ulceration in 12 patients undergoing cancer chemotherapy. The oral distribution or cytotoxic-induced ulcers corresponded to the salivary gutters. There was no difference in the rate of healing of established ulcers between the experimental and placebo groups. However, there was a small delay in the onset and severity of recurrent ulceration. It was concluded that EGF mouthwash does not accelerate ulcer healing, but it may have the potential to protect the oral epithelium from cytotoxic damage.

Antineoplastic Agents↗
PubMed1995

Facial airgun wound.

A case is presented of a patient who received an airgun wound to the soft tissues of the right orbit. Because the pellet ricocheted off the bony orbital rim, it did not penetrate the globe and vision was not impaired. The increasing incidence of airgun wounds in Great Britain is also discussed.

Adult↗
PubMed1994

Fatal sequel to dental implant surgery.

The rare complication of fatal venous air embolism arising as a direct result of dental implant surgery in the mandible is depicted. The deaths arose from the erroneous use of an air/water coolant mixture with internally irrigated implant drills. The pathogenesis and consequence of air embolism is discussed. Practitioners are warned about the dangers of using air-driven equipment during implant surgery.

Air Pressure↗